Báo cáo y học: "Infliximab concentration monitoring improves the control of disease activity in rheumatoid arthritis" doc
Báo cáo y học: "Infliximab concentration monitoring improves the control of disease activity in rheumatoid arthritis" doc
... to
improved control of disease activity. Thus, therapeutic drug
monitoring of infliximab may improve the control of disease
activity in RA.
Competing interests
DM and J-PV took part in clinical trials ... infliximab concentration. Therapeutic drug moni-
toring of infliximab could result in a lowering of dosage in
patients having higher exposure than needed,...
Báo cáo y học: "Probe-level estimation improves the detection of differential splicing in Affymetrix exon array studies" docx
... filtered using various criteria, such
as low intensity or probe specificity, and, finally, by visually
inspecting the intensities of the best candidates within the
genomic context. Ultimately, the detections ... expression intensities are first sum-
marized into an exon-level intensity and the correspond-
ing gene-level intensity . The exon intensity is then
normalized by the...
Báo cáo y học: "Novel approaches to gene expression analysis of active polyarticular juvenile rheumatoid arthritis." pdf
... from the onset of therapy as they either
responded or failed to respond to therapy. In this portion
of the study, disease severity was scored for the degree of
synovitis using a linear scoring system ... means
of identifying the genes involved in a given pathophysiol-
ogy. Our analysis identified key regulators of innate immu-
nity and inflammation including the proi...
Báo cáo y học: "TRAF1/C5 polymorphism is not associated with increased mortality in rheumatoid arthritis: two large longitudinal studies" pot
... and May 1999. Written informed
consent was obtained from all participants. The study was
approved by the appropriate local institutional review
boards of all centers. The primary endpoint in the ... cardiovascular mortality may be
missed, because patients dying of CVD earlier in the
disease course are not part of their cohort. This
hypothesis was corroborated by our resu...
Báo cáo y học: " Th2 cytokines and asthma The role of interleukin-5 in allergic eosinophilic disease" doc
... interleukin-5-induced hyperreactivity was
abated by blocking the activity of interleukin-1, and
interleukin-1β mRNA and protein levels are increased by
interleukin-5. Interleukin-5 may contribute to airway ... between the two
groups in the expression of Th1-type cytokine mRNA such
as interferon-γ [82–85]. The predominant source of inter-
leukin-4 and interleukin-5 mRNA in...
Báo cáo y học: " Pro/con clinical debate: The use of prone positioning in the management of patients with acute respiratory distress syndrome" potx
... ‘rule of rescue’. Intensivists feel
obliged to offer some therapy, any therapy, to a patient in
imminent danger of dying [16].
As is often the case in critical care, a therapy that looks great
from ... respiratory
therapists should not feel that they are preventing an effective
therapy when they voice concerns about the safety of proning
a particular patient. Finally, clinicians...
Báo cáo y học: "Bench-to-bedside review: The evaluation of complex interventions in critical care" ppsx
... all
participants in the group to which they were randomized,
regardless of whether they completed the protocol or not [10])
is the best primary focus of the results. Differences between
the results of an intention-to-treat ... relationship and the underlying biological
plausibility of the intervention. Multiple studies of a complex
intervention may be needed to fully...
Báo cáo y học: "Bench-to-bedside review: The value of cardiac biomarkers in the intensive care patient" pdf
... between the biomarkers and
the severity of the disease, the provision of prognosis, and
the ease of performing the test.
The use of cardiac biomarkers in the ICU continues to evolve
with new findings. ... IL, interleukin; IMA, ischemia-modified albumin; HFABP, heart-type fatty acid
binding protein.
Inflammatory markers of atherosclerotic plaque
Inflammation plays...
Báo cáo y học: " Horizontal gene transfer and the evolution of transcriptional regulation in Escherichia col" ppt
... that relatively few of the TFs
evolved by duplications within the E. coli lineage. Instead, we
found a surprisingly complex history of HGT for many of the
regulators, especially for the neighbor ... Apparently, if paralogous TFs maintain overlap-
ping DNA binding specificities, then a single site can evolve to
bind both TFs. As the evolution of these sites relies on the
fu...
Báo cáo y học: "Vestibulo-ocular monitoring as a predictor of outcome after severe traumatic brain injury" pot
... pro-
vides documentation and permits offline analysis of the OMR.
Thus in the present study, cases were identified where the
OMR was too small to be seen by the naked eye. The correla-
tion of eye movement ... individual prognosis in many cases. This could
be due to the difficulty in detecting diffuse axonal injury
[34,35] and lesions of the brainstem [2].
Recently,...