Báo cáo y học: "HLA-E gene polymorphism associates with ankylosing spondylitis in Sardinia" doc

... TNFalpha associated with ankylos- ing spondylitis: a reconfirmed study. Ann Rheum Dis 2007, 66:1419-1422. 3. Brown MA: Genetics and the pathogenesis of ankylosing spondylitis. Curr Opin Rheumatol 2009, ... citation purposes) Vol 11 No 6 Research article HLA-E gene polymorphism associates with ankylosing spondylitis in Sardinia Fabiana Paladini 1 *, Francesca Belfiore 1,2 *...

Ngày tải lên: 12/08/2014, 11:22

... allele carrying the Bw4-I80 epitope may antagonise the unfavourable interaction of KIR3DL1 with an HLA-B27-peptide. Table 1 Distribution of B27 subtypes in patients with ankylosing spondylitis (AS) ... are located in the intracytoplasmic tail. The inhibitory receptor has a long tail containing immunoreceptor tyrosine inhibitory motifs, whereas the activating receptor has a short t...

Ngày tải lên: 09/08/2014, 08:22

... allele carrying the Bw4-I80 epitope may antagonise the unfavourable interaction of KIR3DL1 with an HLA-B27-peptide. Table 1 Distribution of B27 subtypes in patients with ankylosing spondylitis (AS) ... S, Milicic A, Rubin L, Siminovitch KA, Weeks DE, Calin A, et al.: Whole- genome screening in ankylosing spondylitis: evidence of non- MHC genetic-susceptibility loci. Am J Hum Ge...

Ngày tải lên: 09/08/2014, 08:22

... and microcytotoxicity assays. Preliminary association analysis was conducted by χ 2 test- ing on contingency tables comparing the three genotypic frequencies between cases and control individuals to yield a ... joints involved, with systemic onset disease typically associated with the great- est morbidity. JRA is probably a collection of diseases with complex overlapping etiologies, w...

Ngày tải lên: 09/08/2014, 06:22

... Interleukin 1β; IL2RB: Interleukin 2 Receptor, Beta; IL-8: Interleukin 8; IL13RA1: Interleukin 13 Receptor, Alpha 1; IPA: Ingenuity Pathways Analysis; IRF1: Interferon Regulatory Factor 1; ISGF-3: Interferon ... assessed with Ingenuity Pathways Analysis (IPA) Software (Inge- nuity, Inc.). For analysis purposes the IPA software assigns gene names (based on each probe, indicated in parent...

Ngày tải lên: 13/08/2014, 13:22

... cardio- myopathy in Kearns–Sayre syndrome with deficiency of cyto- chrome-c-oxidase in cardiac and skeletal muscle. An enzymehistochemical—ultrammunocytochemical fine structural study in longterm ... decline in the energy production of the affected cell(s), result in abnormal electron transport system (ETS) enzyme phenotypes, atro- phy and would, ultimately, lead to fiber loss. Worki...

Ngày tải lên: 17/03/2014, 23:20

... IgG- expressing plants. Again this is consistent with the model for BiP in assisting protein folding and increasing throughput of the ER. In mammals, BiP associates with both Ig light and heavy chains ... similarly involved in assisting the folding of plant proteins [17,20]. BiP is also found in association with assembly defective proteins in plants [21,22]. Calreticulin is...

Ngày tải lên: 31/03/2014, 08:20

... pathways contributing to fibrogenesis in SSc It is likely, then, that targeting the ability of TGFβ to induce specific pathways or genes will be of benefit in generating selective therapies in SSc. ... although the generic TGFβ signaling pathways may not be suitable targets for selective drug intervention in SSc, examining how individual target genes are selectively induced is likely...

Ngày tải lên: 09/08/2014, 08:22

... experimentally induced intron reten- tion in a number of genes containing introns. Yeakley et al. [22] detected alternative splicing in six human genes using a fiber-optic microarray platform. ... Genomewide analysis of mRNA processing in yeast using splicing-specific microarrays. Science 2002, 296:907-910. 22. Yeakley JM, Fan JB, Doucet D, Luo L, Wickham E, Ye Z, Chee MS, Fu XD: Profil...

Ngày tải lên: 09/08/2014, 20:20

... specifically, systemic lupus erythematosus (SLE). First described by Zeigler [1] in 1888 and derived from the Greek marantikos, meaning “ wasting away” ,ME typical ly involves a single valve with rare involvement ... techniques are generally adequate to detect the etiology of endocarditis. While marantic endocarditis lacks inflammatory cells and normally involves a single valve, purulence...

Ngày tải lên: 10/08/2014, 09:22