Báo cáo y học: " Different regulation of cigarette smoke induced inflammation in upper versus lower airways" pot

... Access Different regulation of cigarette smoke induced inflammation in upper versus lower airways Wouter Huvenne 1* , Claudina A Pérez-Novo 1 , Lara Derycke 1 , Natalie De Ruyck 1 , Olga Krysko 1 , ... effects of CS o n upper airways, especially in comparison to the lower airways. We therefore aimed to investigate the inflammatory response of the upper airway...

Ngày tải lên: 12/08/2014, 11:22

... of smok- ing of two cigarettes by healthy intermittent smokers who refrained from smoking nine days before the study period. In this way, temporary effects on the airways due to chronic smoking ... It would be interesting to study the acute effects of smoking on lung tissue. Finally, CO in cigarette smoke may have dampened the inflammatory response, especially in the early pha...

Ngày tải lên: 12/08/2014, 18:21

... 1 of 3 (page number not for citation purposes) Respiratory Research Open Access Correction Differential effects of cigarette smoke on oxidative stress and proinflammatory cytokine release in ... stain- ing pattern overlaying the green fluorescent staining of each group is given here as Figure 1. In addition in Figure 7 (Figure 2 in this paper) &apos ;Cigarette smoke extr...

Ngày tải lên: 12/08/2014, 15:21

... pro- inflammatory cytokines in response to either CSE or whole smoke direct exposure. Interestingly, CSE caused release of proinflammatory cytokines (IL-8 and IL-6) in SAEC (Table 2). CSE also induced ... measured by enzymatic recycling assay and 4-hydroxy-2- nonenal levels by using lipid peroxidation assay kit. The levels of proinflammatory cytokines (e.g. IL-8 and IL-6) were mea...

Ngày tải lên: 12/08/2014, 16:20

... microRNA regulation. A model for microRNA mediated genetic buffering In the following we extend the reprogramming hypothesis originally derived from yeast to mammals by proposing a kinetic model in ... simulation of regulation of duplucate genes by microRNAFigure 5 Dynamic simulation of regulation of duplucate genes by microRNA. (a) A schematic diagram of a hypothetical m...

Ngày tải lên: 14/08/2014, 20:22

... to activation -induced cell death. Moreover, these cells are characterized by intracellular storage of the cytolytic proteins perforin and granzyme B and are functionally specialized for cytotoxic activity ... joint involvement and rapid joint progression confirm observations that the frequency of CD4 + CD28 – T cells may correlate with the risk of occurrence of joint erosions in R...

Ngày tải lên: 09/08/2014, 01:22

... University, Husargatan 3, SE-751 21 Uppsala, Sweden. § Key Laboratory of Zoonosis, Ministry of Education, Jilin University, Xi An Da Lu 5333, Changchun 130062, China. ¶ Laboratory of Parasitology, ... are known to interact with the host immune system [12]. These include the family of P. falciparum erythrocyte membrane protein 1 (PfEMP1) proteins, employed by the parasite to seques...

Ngày tải lên: 09/08/2014, 20:20

... damage of proteins as evidenced by immunoblotting Oxidative damage of lung proteins was evidenced by immunoblotting of the dinitrophenylhydrazone deriva- tives of protein carbonyls followed by densitometric ... morphometric analysis. Protein oxidation was measured through oxyblot analysis of dinitrophenylhydrazone derivatives of the protein carbonyls of the oxidized proteins. A...

Ngày tải lên: 11/08/2014, 08:21

... lung injury within a few days. Upon hyperoxic exposure, the inducible nitric oxide synthase (iNOS) is activated by a variety of proinflammatory cytokines both in vitro and in vivo. In the present study, we ... calmodulin binding sequence, and a C-terminal reductase domain [21,22]. Inducible NOS is expressed following induction by a variety of inflammatory cytokines such as TNF-α [22...

Ngày tải lên: 12/08/2014, 18:21

... obligatory step in the rep- lication cycle of retroviruses, hence by blocking RT activity viral infection can be abolished. We used 3'-azido-2'- deoxythymidine (AZT), a potent inhibitor of ... PCR assay Immunofluorescence imaging of MMTV-infected Hs578T cellsFigure 2 Immunofluorescence imaging of MMTV-infected Hs578T cells. The expression of capsid proteins in the thir...

Ngày tải lên: 13/08/2014, 05:22