... receptor γ inhibits interleukin-1β -induced membrane-associated prostaglandin E2 synthase-1 expression in humansynovial fibroblasts by interfering with Egr-1. J Biol Chem 20 04, 27 9 :22 057 -22 065.17. ... prevent the proteoglycan degradation induced by pro -inflammatory cytokines [13]. Furthermore, PPARγligands were shown to reduce the incidence and severity ofOA in an experimental model, preventing ... induction of IL-6 and LIF in normal articular human chondrocytes involves the ERK, p38 and NFκB signaling pathways. Cytokine 20 04, 28 :17 -24 . 42. Liacini A, Sylvester J, Li WQ, Zafarullah M: Inhibition...