Báo cáo y học: " The cationic amino acid transporter 2 is induced in inflammatory lung models and regulates lung fibrosis" pps

... fibrosis is increased in CAT2-deficient mice as measured by the whole lung hydroxyproline assay [8]. Interestingly, this baseline fibrosis is not evident his- tologically by trichrome staining, ... would be involved in lung fibrosis. This is based on the following: 1) CAT2 is upregulated in bleomycin -induced pulmonary fibrosis [19] and 2) argi- nase metabolizes argi...

Ngày tải lên: 12/08/2014, 11:22

... directly target Bcl -2 in the loop domain, mimics activity of Nur77, thereby facilitating the initia- tion of apoptosis [31]. Whether Bcl -2 phenotype changes phenomenon occur in arsenic trioxide -induced ... anti- body. The novel finding from this work was that SGC7901 cells highly expressed Bcl -2, but they were weakly stained by the anti-Bcl -2 BH3 antibody, suggest- in...

Ngày tải lên: 09/08/2014, 03:21

... receptor γ inhibits interleukin-1β -induced membrane- associated prostaglandin E2 synthase-1 expression in human synovial fibroblasts by interfering with Egr-1. J Biol Chem 20 04, 27 9 :22 057 -22 065. 17. ... prevent the proteoglycan degradation induced by pro -inflammatory cytokines [13]. Furthermore, PPARγ ligands were shown to reduce the incidence and severity of OA in an...

Ngày tải lên: 09/08/2014, 10:20

... transport [22 ,25 ]. ( A ) (C) (B) ȕ-actin NIS wt R9A R82A K86A H 226 A R 228 A R239A R241A E79A D163A D233A D237A D311A D 322 A D331A NIS ȕ-actin wt R9A R82A K86A H 226 A R 228 A R239A NIS ȕ-actin ... participated in the design of (A) (B) Extracellular D331 H 226 R 228 D331 D311 D233 E79 R 82 R241K86 D163 D 322 D237 R239 (C) H 226 R241 R 228 K86 Intracellular R 82 E7...

Ngày tải lên: 10/08/2014, 05:21

... recently reported, one in 20 05 in the U K, and the other in 20 06 in the USA. In both cases, the G MuV genotype was identified, even though both countries have be en using the mumps Jeryl L ynn vaccine, ... MuV infection by inducing both the Th1 and Th2 immune specific responses and probably secretion of IgA in the mucosa. Discussion MuV HN protein is a hi...

Ngày tải lên: 12/08/2014, 04:20

... Alternatively, this single amino acid substitu- tion might influence the configuration of surrounding loops by the changes in the side chain and polarity with- out directly involving the binding site ... complementarity between CA and TRIM5α. Second, even if the residue is not directly in the binding site, the change in the side chain and polarity can influen...

Ngày tải lên: 13/08/2014, 01:20

... [22 24 ] or possibly by the interaction with a nonsynthetase protein [25 ,26 ]. The active site of class II aaRSs contains the motif 2 loop which is involved in binding of ATP, an amino acid, and ... selectivity of aminoacyl-tRNA synthetases in vitro indicate that the upper limit for error in the selection of correct amino acid for protein synthesis is in the...

Ngày tải lên: 31/03/2014, 08:20

... were leucine and isoleucine, tyrosine and phenylalanine, valine and alanine, threonine and serine, gluta- mine and asparagine, and arginine and lysine. The paired amino acids were assigned the same ... span- ning such large ranges typically yield scores that lack musicality. They also examined a nine-note scale, but without distinguishing among amino acids having the s...

Ngày tải lên: 14/08/2014, 07:21

... 21 1 29 32 5 139 19 720 100 Total 22 6 9 438 16 415 16 6 12 23 333 12 633 24 2 657 100 Female 0-9 years 20 16 20 16 11 10 1 1 8 6 63 51 123 100 10 -29 years 28 8 56 16 39 11 12 3 76 21 151 42 3 62 ... (101) Other skin symptoms other S29 (34) Other musculoskeletal symptoms L29 (396) Other 465 10 2. 3 10 400 Endocrine/metabolic symptoms T29 (11) Urinary/male genital symptoms U2...

Ngày tải lên: 25/10/2012, 09:56

... Another factor may be the differences in sta- tistical analyses. Direct analyses on linear data were used in the present study and the study by Mathelin et al. (27 ). Li et al., on the other hand, ... undiagnosed during the early-stage (22 ). Small lesions are frequently missed and may not be visible, even by mammography, particularly in young women and in those...

Ngày tải lên: 25/10/2012, 11:15