Báo cáo y học: "Bone Morphogenetic Protein (BMP)-4 and BMP-7 regulate differentially Transforming Growth Factor (TGF)-β1 in normal human lung fibroblasts (NHLF)" pdf

... regulate differentially Transforming Growth Factor (TGF)-β1 in normal human lung fibroblasts (NHLF) Sophie Pegorier, Gaynor A Campbell, A Barry Kay and Clare M Lloyd* Abstract Background: Airway remodelling ... BMP-4 and BMP-7 are able to regulate the synthesis and production of ECM proteins, MMPs and α- SMA in primary lung fibroblasts. BMP-4 inhibits...

Ngày tải lên: 12/08/2014, 11:22

... of Commentary Bone morphogenetic proteins, genetics and the pathophysiology of primary pulmonary hypertension Mark De Caestecker* and Barbara Meyrick* † *Department of Medicine, Vanderbilt University Medical ... signaling pathway [7,8], but also cell-type-dependent activation of other signaling path- ways, including TGF-β activated kinase 1 mediated p38 mitogen activated protein kinas...

Ngày tải lên: 12/08/2014, 18:20

... space Modification of ligand-receptor affinity ) usually by binding to ligand dimers Dimeric secreted proteins such as noggin, chordin, follistatin and GDF3 bind and therby inactivate BMP dimers ... Dephosphorylation of the linker regions of Smad1 and Smad2 ⁄ 3 by small C-terminal domain phosphatases has distinct outcomes for bone morphogenetic protein and transforming growth f...

Ngày tải lên: 19/02/2014, 00:20

... for bone morphogenetic protein signaling in cartilage homeostasis. Finally, this signaling pathway is likely to play a steering role in the synovium. Introduction The classic signs and symptoms ... osteophyte formation. Interestingly, osteo- phytes induced by BMP2 injection were found predominantly in the regions where the growth plate met the joint space, whereas TGFβ-induced o...

Ngày tải lên: 09/08/2014, 10:20

... SD. Results Herbimycin A inhibits nitric oxide production induced by BCG and SP-A-BCG complexes Activation of intracellular protein tyrosine kinases is a common pathway involved in signalling induced by a variety ... (200 mM) and reprobed using anti-ERK antibody. Densitometry was per- formed to quantify protein band intensity using the UN- SCAN-it digitizing system. Immunoprecipita...

Ngày tải lên: 12/08/2014, 14:20

... Simons, K. (1999) Clusters of glycolipid and glycosylphosphatidyl-inositol-anchored proteins in lymphoid cells: accumulation of actin regulated by local tyrosine phosphorylation. Eur. J. Immunol. 29 ... consequences in T cells. First, rafts may concentrate the a chains (CD25) in the vicinity of signaling IL-2R b and c c chains, forming a common signaling platform in the membrane,...

Ngày tải lên: 17/03/2014, 23:20

... alpha-inducible protein 6 (IFI6) Hs00242571_m1 Interferon, gamma-inducible protein 16 (IFI16) Hs00194261_m1 Interferon, alpha-inducible protein 27 (IFI27) Hs00271467_m1 Interferon, gamma-inducible protein ... genes – interferon-induced protein with tetratricopeptide repeats 1 (IFIT1), interferon-induced protein with tetratricopeptide repeats 3 (IFIT3), and interferon alpha-indu...

Ngày tải lên: 09/08/2014, 01:22

... haplotypes at chromosome 1q41 in human systemic lupus erythematosus”, by RR Graham et al. Anne C Barton and Jane Worthington Arthritis and Rheumatism Campaign Epidemiology Unit, University of ... would be expected by chance alone. However, linkage typically extends for 10 cM or more and such a region could contain 500 genes. Varia- Commentary Commentary on “Genetic linkage and tr...

Ngày tải lên: 09/08/2014, 03:24

... respectively. Chondrocyte phenotype was investigated using RT-PCR and Western blot analysis. Over 7 days, sphingomyelinase increased the release of newly synthesized sulphated glycosaminoglycan and ... into the media, whereas inhibition of PKR in sphingomyelinase-treated cells reduced the level of newly synthesized sulphated glycosaminoglycan and collagen. Sphingomyelinase treated cho...

Ngày tải lên: 09/08/2014, 08:22

... guanylate binding protein; HLA: human leukocyte antigen; IFI: interferon-inducible; IFIT: interferon-induced protein with tetratricopeptide repeats; IFN: interferon; IL: interleukin; IRF7: interferon ... SLE patients and from healthy women were analyzed using DNA microarray analysis. Differentially expressed genes classified into the immune response category were selected and anal...

Ngày tải lên: 09/08/2014, 13:22