Báo cáo y học: "Corticosteroid suppression of lipoxin A4 and leukotriene B4from alveolar macrophages in severe asthma" ppsx

... the persistent inflammation in severe asthma has been supported by the demonstration of an increased genera- tion of cysteinyl-leukotrienes with impaired biosynthesis of lipoxin A 4 (LXA 4 ) ... pro- duction of cysteinyl-leukotrienes and LTB 4 were increased[9]. In addition, similar findings have been reported in airway fluids for the levels of these lipid medi- ators;...

Ngày tải lên: 12/08/2014, 11:22

... cells, macrophages, granulocytes and particular neutrophils into the synovial lining and fluid and the periarticular spaces. These infiltrating cells produce abundant cytokines, dominated mainly by ... inflammatory type of cytokines such as tumor necrosis factor (TNF-α) and IL-1, which further activate effector cells such as macrophages and synoviocytes, finally leading to the...

Ngày tải lên: 09/08/2014, 06:23

... streptomycin, pH 7.4 (maintain medium). Cells were passaged every 5 to 7 days to maintain exponential growth. DEN-1 strain GZ02-218 was passaged by infecting monolayers of C6/ 36 cells and viruses ... replication and in creased C6/36 cell survival rate. siRNA may offer a potential new st rat- egy for prevention and treatment of DEN infection . The stability and inhibitory effici...

Ngày tải lên: 12/08/2014, 01:22

... Alveolar macrophages and monocytes from healthy donors were analyzed by flow cytometry using phycoerythrin (PE)-coupled mouse anti-TLR2, TLR4 and TLR9 antibodies and their corresponding isotype ... hours of incubation with M.tb DNA in both monocytes and alveolar macrophages in five of five study subjects indicating a slower kinetic of TLR9 mRNA generation than in t...

Ngày tải lên: 12/08/2014, 14:20

... level of 30–40 cmH 2 O results in lung overinflation and may cause pulmonary interstitial edema, inflamma- tion and elevated vascular permeability, a picture that resembles acute respiratory distress ... respiratory distress syndrome ( ARDS) or acute lung injury (ALI) [2-5]. The pulmonary injury is often distributed quite heterogeneously. This means that normally functioning parts of...

Ngày tải lên: 12/08/2014, 18:20

... characterised by accumulation of pigmented granules (probably copper) in hepatocytes, and inflammation with lymphocytes and pigmented (probably copper) macrophages. HE staining. (B) Centrolobular ... They found that chronic copper toxicity in Long- Evans Cinnamon rats involved the uptake of copper- loaded metallothioneins into lysosomes, where it was incompletely degraded and...

Ngày tải lên: 13/08/2014, 13:20

... predictor of sexual initiation in the final step of the analysis. Psychopathology and Risky Sexual Behavior The second study question investigated whether internal- izing and externalizing psychopathology ... Prevention and Skonviks Psychiatric Clinic, Karolinska Institute, Sweden, 4 Yale School of Medicine Child Study Center, Yale University, New Haven, CT, USA and 5 Yale...

Ngày tải lên: 13/08/2014, 18:21

... IL-8 and LTB4 and subsequent neu- trophil recruitment [20]. Accordingly, in BALF and spu- tum of patients with COPD neutrophil activation and elevated levels of proinflammatory cytokines and chem- okines ... Forslid J, Hed J: Quenching of intracellular autofluorescence in alveolar macrophages per- mits analysis of fluorochrome labelled surface antigens by flow cytofl...

Ngày tải lên: 12/08/2014, 18:21

... events induced by feeding OVA, i.e. bystander suppression, reduced the severity of arthritis in animals immunized with BCII and OVA. Anti-BCII specific antibody responses and cytokine secretion by ... Earlier studies have indicated that induction of CIA involves initia- tion of an inflammatory process via the classical comple- ment pathway and also via binding of IgG immune c...

Ngày tải lên: 09/08/2014, 01:23

... the vast majority of IFN-g producing cells were also CFSElow, suggesting that cells producing cyto- kines in response to peptides were also proliferating (Figure 3b). Interestingly, we found that ... mutation in the IW9 epitope and any of the ES8 plasma mutations in TW10, however, showed considerably less infection of donor cells than the control viruses. Virus containing the T2...

Ngày tải lên: 13/08/2014, 01:21