Báo cáo y học: "Altered fibroblast proteoglycan production in COPD" pptx
Báo cáo y học: "Altered fibroblast proteoglycan production in COPD" pptx
... study to examine the proteoglycan production in both centrally and distally derived fibroblasts from COPD patients. In our study, an alteration in proteoglycan production was observed in fibroblasts ... total amount of proteoglycan production. Surprisingly, these data are consistent with a rat model investigating bleomy- cin-induced pulmonary fibrosis, which showed that big...
Ngày tải lên: 12/08/2014, 11:21
Báo cáo y học: "Altered dendritic cell distribution in patients with common variable immunodeficiency" pot
... (DCs) in the generation of immunoglobulin-secreting plasma cells. In the work reported herein, we analyzed the frequency of peripheral blood plasmacytoid DCs (pDCs) and myeloid DCs (mDCs) in a cohort ... disease. All the patients included in this study had blood CD19 + CD3 - B-lymphocyte counts above 1% of peripheral blood lym- phocytes. The CVID patients were divided into two groups...
Ngày tải lên: 09/08/2014, 06:23
Báo cáo y học: "Altered fractalkine cleavage results in an organ-specific 17 kDa fractalkine fragment in salivary glands of NOD mice" pot
... leukocyte subsets, which exert cytotoxic effector functions. Fractalkine may also lead to increased interferon-γ, tumor necrosis factor-α and granulo- cyte monocyte colony stimulating factor production ... play a crucial role in the initiation, accumulation and retention of inflammatory cells in the salivary glands. This corresponds to properties of fractalkine reported in other infla...
Ngày tải lên: 09/08/2014, 10:23
Báo cáo y học: "α Tumour necrosis factor-α production in fibrosing alveolitis is macrophage subset specific" ppt
... µg/ml recombinant TNF-α. Endo- toxin contamination was excluded by assaying secretion in the presence of 5 µg/ml endotoxin inhibitor polymyxin B sulphate. Preliminary time course cultures of PBMC ... saline for 10 min followed by APAAP staining. For the RFD7 mon- oclonal antibody the monolayers were fixed in 4% paraformaldehyde/7% sucrose for 10 min, treated with 50 mmol/l glycine for 10...
Ngày tải lên: 12/08/2014, 18:20
Báo cáo y học: "Development of proteoglycan-induced arthritis depends on T cell-supported autoantibody production, but does not involve significant influx of T cells into the joints." potx
... cells (nearly all CD4 + ) in the synovial fluid of the arthritic joints of mice by flow cytometry. The sligh t discrepancy between TPM imaging and flow cytometry in the fre- quency of fluorescent ... IgG-containing immune complexes (ICs) in the joints has been repeat- edly reported in RA and serum/Ab-induced arthritis models [2, 53-56]. Some Abs, which may access the joints by crossin...
Ngày tải lên: 12/08/2014, 12:20
Báo cáo y học: " Altered intercellular communication in lung fibroblast cultures from patients with idiopathic pulmonary fibrosis" ppsx
... membrane-per- meable calcein-AM is intracellularly hydrolyzed by non- specific esterases producing the green fluorescent polyani- onic calcein. In order to study the dye spreading through adjacent ... effect remains to be determined [30-32]. As expected, CBX specifically blocked GJIC in our system in a concentration dependent manner as shown in Figs. 3, 4 and 5A. Calcein dye coupling...
Ngày tải lên: 12/08/2014, 16:20
Báo cáo y học: "IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis κ synovial fibroblasts via NF-κB- and PI3-kinase/Akt-dependent pathways" doc
... signaling in human monocyte cell line [10] and embryonic fibroblasts [11], respectively, and yet cytoplasmic players transmitting IL-17-mediated activation in RA synovial fibroblasts remain to be investi- gated. ... sCD40L R120 Introduction Increasing attention is being given to the role of IL-17, a proinflammatory cytokine produced by activated T cells, in the perpetuation of joint inf...
Ngày tải lên: 09/08/2014, 01:23
Báo cáo y học: "Altered signalling thresholds in T lymphocytes cause autoimmune arthritis." ppsx
... regulatory loop by generating knock -in mouse lines expressing the 75 9Y to F mutation. Commentary Altered signalling thresholds in T lymphocytes cause autoimmune arthritis Andrew P Cope Kennedy Institute ... tyrosine kinase-2 to the receptor complex (for review [4,5]). Receptor engagement leads to phosphorylation of tyrosine residues in the cytoplasmic domain of gp130. Phosphotyrosine...
Ngày tải lên: 09/08/2014, 01:23
Báo cáo y học: "Altered expression of inflammatory cytokines in primary osteoarthritis by human T lymphotropic virus type I retrovirus infection: a cross-sectional study" pps
... changes in HAAP include marked proliferation of synoviocytes in the synovial lining layer, gross infiltration of lymphocytes, and migration of atypical lymphocytes with nuclear indentation into ... osteophytes and definite joint space narrowing. b Scoring was as follows: +/-, minimum staining in one area of the tissue; +, patchy staining involving several areas; ++, moderate diffuse s...
Ngày tải lên: 09/08/2014, 01:23
Báo cáo y học: "Apolipoprotein A-I infiltration in rheumatoid arthritis synovial tissue: a control mechanism of cytokine production" pot
... of inflammatory cells, including monocytes and lymphocytes [1]. It has been proposed that the first cells to infiltrate syn- ovial tissue are T lymphocytes, suggesting that they have an important role in ... newly emerging anti-inflammatory properties, may have important implications for treatment in chronic inflam- matory diseases. Competing interests The authors declare that they have n...
Ngày tải lên: 09/08/2014, 01:24