Báo cáo y học: "Cytosolic phospholipase A2α mediates Pseudomonas aeruginosa LPS-induced airway constriction of CFTR -/- mice" potx

... provided the original work is properly cited. Research Cytosolic phospholipase A2α mediates Pseudomonas aeruginosa LPS-induced airway constriction of CFTR -/- mice Yong-Zheng Wu 1,2 , Mohammad Abolhassani 3 , ... the induction of airway constriction in CFTR -/- mice. Our studies suggest that cPLA2α, which catalyzes the key step of AA release, plays a role...

Ngày tải lên: 12/08/2014, 11:21

... Biochemistry and Microbiology, University of Leeds, UK Cytosolic phospholipase A 2 -a (cPLA 2 -a) is an 85 kDa protein that specifically cleaves the sn-2 fatty acyl of phospholipid to liberate free fatty ... potent vasodilator and inhibitor of platelet activation, through the action of cyclooxygenase (COX) enzymes. Here we study the relocation of cPLA 2 -a in human EA.hy.926 endoth...

Ngày tải lên: 16/03/2014, 18:20

... population of 177 random donors from our general population. DNA was isolated from lym- phocytes by standard procedures. HLA-C alleles were specif- ically amplified with a combination of the sense ... for 50 seconds (50 cycles), with a initial denaturation step of 98°C for 1 minute and a final exten- sion step of 70°C for 5 minutes. The specificity of the PCR- SSOP (polymerase chain...

Ngày tải lên: 09/08/2014, 08:23

... thereby adequately hydrate the airway surface liquid. A widely held hypothesis to explain the predisposition of CF airways to chronic infection is that reduced volume of isotonic periciliary airway ... Chronic infection of CF airway by P. aeruginosa is associated with the formation of bio- films [31]. Since neutrophils enhance the formation of P. aeruginosa biofilms [32],...

Ngày tải lên: 12/08/2014, 13:22

... day, 3 days and 7 days) post-pneumonectomy spanning the period during which the bulk (>80%) of lung regeneration occurs, as measured by changes in vital capacity [12]. Following analysis of ... genes were differentially expressed between PNY and SHAM at 6 hour, 1 day, 3 day and 7 day post-pneumonectomy respectively (complete data not shown), with an S-score of ≥ 3 or ≤ -3 (equivalent...

Ngày tải lên: 12/08/2014, 14:20

... maxi- mal inspiratory pressure) is the most widely used and is a simple way to gauge respiratory muscle strength and to quantify its severity [1-3]. When we analyze maximal respiratory pressure, we should ... study did not find any correlation with weight and age, proba- bly because our patients had reached approximately 60 years of age with the same normal body weight. For these reasons ou...

Ngày tải lên: 12/08/2014, 15:21

... unpleasant feeling in your throat Oropharyngeal Itching – 2 items: • a dry throat • an itchy feeling on the roof of your mouth • an itchy feeling in the back of your throat Oropharynx Problems – 9 ... item: • any form of dental decline (tooth decay, tooth staining etc.) Skin, Hair and Nails – 7 items: • dry skin Eye Dryness – 1 item: • dry skin on the face • dry eyes • bruising easily •...

Ngày tải lên: 12/08/2014, 16:20

... work is properly cited. Pseudomonas aeruginosa virulence<p>Sequencing of a highly virulent strain of <it> ;Pseudomonas aeruginosa </it>and comparison to a previously sequenced, ... detailed description of the contents of the table and serves as a legend for the first worksheet. Additional data file 1Summary of supplementary methodsSummary of supplementary m...

Ngày tải lên: 14/08/2014, 17:22

... cluster of group IVA phospholipase A 2 (Lys488/Lys541/Lys543/Lys544) is involved in translocation of the enzyme to phagosomes in human macrophages. J Lipid Res 2009, 51(2):388-99. 31. Meliton AY, ... design of the study, and to the manuscript writing. NMM and AYM performed the data analysis. AYM and LNM performed the assays for gIVaPLA 2 enzyme activity, PMN migration, F- actin p...

Ngày tải lên: 11/08/2014, 03:20

... are likely to be interactions of the PLA2 enzymes with elements of antigen-specific immunity. Fur- thermore, sPLA2s influence levels of proinflammatory cytokines in a variety of cell types (either ... contribution of the innate immune system to multiple sclerosis (MS), including the activity of acute inflammatory mediators. The purpose of this study was to test the involvement...

Ngày tải lên: 19/06/2014, 22:20