Báo cáo y học: "Histone deacetylase inhibitor, butyrate, attenuates lipopolysaccharide-induced acute lung injury in mice" pptx

... Cytokine-mediated inflammation in acute lung injury. Cytokine Growth Factor Rev 2003, 14:523-535. 28. Chen J, Liu X, Shu Q, Li S, Luo F: Ghrelin attenuates lipopolysaccharide- induced acute lung injury through ... article as: Ni et al.: Histone deacetylase inhibitor, butyrate, attenuates lipopolysaccharide-induced acute lung injury in mice. Respiratory Researc...

Ngày tải lên: 12/08/2014, 11:21

... birth initiates an inflamma- tory cascade characterized by inflammatory cell influx into the lungs, increased alveolar protein, inflammatory cytokine mRNA induction, and systemic acute phase inflammatory ... inflammatory cells and airway thickness of mesenchyme on Injury scoring. Lung Cytokines and Acute Phase Reactants The initial stretch injury increased IL-1β, IL-6, monocyte chem...

Ngày tải lên: 12/08/2014, 14:20

... in Acute Renal Disease (PICARD) study Abstract Introduction: Serum creatinine concentration (sCr) is the marker used for diagnosing and staging acute kidney injury (AKI) in the RIFLE and AKIN ... patients Abbreviations AKI: acute kidney injury; AKIN: Acute Kidney Injury Network; CKD: chronic kid- ney disease; GFR: glomerular filtration rate; IQR: interquartile range; PICARD:...

Ngày tải lên: 13/08/2014, 20:22

... LPS-induced lung injury in rats. Pulm Pharmacol Ther 2009, 22:318-25. 24. Kabay B, Teke Z, Aytekin FO, Yenisey C, Bir F, Sacar M, Erdem E, Ozden A: Pyrrolidine dithiocarbamate reduces lung injury ... signal pathway inhibitors may be an alter native of therapeutic strategies for ALI/ARDS. Keywords: acute lung injury TNF-a?α?, ICAM-1, NF-?κ?B, pyrrolidine dithiocarbamate Backgr...

Ngày tải lên: 18/06/2014, 19:20

... LPS-induced lung injury in rats. Pulm Pharmacol Ther 2009, 22:318-25. 24. Kabay B, Teke Z, Aytekin FO, Yenisey C, Bir F, Sacar M, Erdem E, Ozden A: Pyrrolidine dithiocarbamate reduces lung injury ... signal pathway inhibitors may be an alter native of therapeutic strategies for ALI/ARDS. Keywords: acute lung injury TNF-a?α?, ICAM-1, NF-?κ?B, pyrrolidine dithiocarbamate Backgr...

Ngày tải lên: 20/06/2014, 03:20

... deacetylase inhibitors block cartilage glycosaminoglycan and collagen loss induced by IL-1α/OSMHistone deacetylase inhibitors block cartilage glycosaminoglycan and collagen loss induced by IL-1α/OSM. ... K, Komiyama T, Miyazawa S, Shen ZN, Furumatsu T, Doi H, Yoshida A, Yamana J, Yamamura M, Ninomiya Y, et al.: Histone deacetylase inhibitor suppression of autoantibody-mediated arthrit...

Ngày tải lên: 09/08/2014, 06:22

... Brosch G: Binding mode analysis of 3-(4-benzoyl-1- methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide: a new synthetic histone deacetylase inhibitor inducing histone hyperacetylation, growth inhibition, ... 3-(4- toluoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propena- mide; ( MS-275): [N-(2-aminophenyl)-4-[N-(pyridine-3- ylmethoxy-carbonyl)aminomethyl]benzamide]; (PDTC): ammo nium pyrrolidinedithio...

Ngày tải lên: 11/08/2014, 08:22

... performed by the scoring sys- tem described previously, in which 0 = no inflammation, 1 = slight thickening of the synovial cell layer and/or some inflammatory cells in the sublining, 2 = thickening of ... Arthritis was induced in SKG mice by zymosan A injection. Trichostatin A, a histone deacetylase inhibitor, was administered and its effects on arthritis were evaluated by joint sw...

Ngày tải lên: 12/08/2014, 15:23

... mesodermal lineages are acti- vated. This transcriptional reprogramming is regulated by changes in histone H3 methylation of lysines 4 and 27. His- tone deacetylase inhibitors may have applications in ... operating in stem cells. Among them, the pharmacological agent Trichostatin A (TSA) is particu- larly potent, inhibiting the enzymatic activity of deacetylases and thus promoting his...

Ngày tải lên: 14/08/2014, 08:21

... 9841–9853. 46 Weisgraber KH, Innerarity TL & Mahley RW (1982) Abnormal lipoprotein receptor-binding activity of the human E apoprotein due to cysteine–arginine inter- change at a single site. J Biol ... vein, and glucose levels were measured. Determination of plasma insulin and leptin levels Insulin and leptin levels in the plasma of mice were deter- mined spectrophotometrically by ELIS...

Ngày tải lên: 17/03/2014, 17:20