Báo cáo y học: " The inhaled phosphodiesterase 4 inhibitor GSK256066 reduces allergen challenge responses in asthma" pdf

... baseline creatinine, mechanical ventilation and level of care were asso- ciated with ICU-acquired hypernatraemia. Outcomes of care Length of stay and mortality in the ICU and hospital were increased ... median number of days of hyponatraemia (IQR = one to three days) and hypernatraemia (IQR = one to five days) was two. Multivariable analysis of patient characte...

Ngày tải lên: 25/10/2012, 10:31

... properties of statistical in- ference and underpins the basis of probability theory [18, 19]. Gotway and Young [17] outline a combination of spatial smoothing and geostatistical upscaling or aggregation ... 2007.06.28 We investigated changes in the geography of Chronic Obstructuve Pulmonary Disease (COPD) hospitalization charges in California over the period...

Ngày tải lên: 26/10/2012, 09:57

... specifically induced on arabinose and galacturonic acid and plays an important role in the degradation of pectic hairy regions Ronald P. de Vries 1† , Lucie Par ˇ enicova ´ 1‡ , Sandra W. A. Hinz 2 , ... Potato arabinogalactan consists of 86% D -galactose and 6.6% L -arabinose, while soy arabinogalactan consists of 57% D -galactose and 38% L -ar...

Ngày tải lên: 21/02/2014, 01:21

... as independent modification of CYP11B2 reaction steps. The combination of functional data and computer modelling of CYP11B2 suggests an indirect involvement of r esidue 147 in the regulation of ... [17–19,41,42]. These stuc tures are mainly located in the C-terminal regions of CYP11B1 and CYP11B2. So far, the role of distinct amino acids of the N-terminal...

Ngày tải lên: 24/03/2014, 03:21

... 4). Similarly, Shaanan [31] reported the stereochemistry of the iron -dioxygen bond in human HbO 2 by single-crystal X-ray analysis. In the a chain, the distance between N e of His (E7) and the terminal ... HbO 2 , and 50 l M for valency hybrid Hb. Ó FEBS 2002 The a1 b1 contact in HbO 2 autoxidation (Eur. J. Biochem. 269) 207 The a1 b1 contact of...

Ngày tải lên: 31/03/2014, 15:20

... Therefore, alteration of the charge of the protein could be induced at the vicinity of the monolayer. A difference in the orientation of the protein moiety during the insertion process into the ... the protein were probably affected by electro- static interactions with the lipid layers. Our results indicate that the penetration of the protein into the lipid...

Ngày tải lên: 31/03/2014, 21:21

... digestive disturbances, and allergy-induced asthma [20-23]. A variety of treatment strategies for allergy exist, which include pharmacotherapy, allergen avoidance and elimi- nation, and allergen-immunotherapy ... vaccination and allergen-immunotherapy Vaccination Allergen-Immunotherapy Similarities Clinical history Over a century Nearly a century Therapeutics contains adjuva...

Ngày tải lên: 08/08/2014, 21:20

... rs3738919-C allele of the ITGAV gene is associated with RA in the European Caucasian population, suggesting ITGAV as a new minor RA susceptibility gene. AFBAC = affected family-based controls; bp = base ... rs3738919 in a first sample of French Caucasian families, the same trend in replication sample 2, and again a significant association in replicati...

Ngày tải lên: 09/08/2014, 10:20

... citation purposes) Vol 10 No 3 Research article The human anti-IL-1β monoclonal antibody ACZ885 is effective in joint inflammation models in mice and in a proof-of-concept study in patients with ... activity. Proof-of-concept clinical trial in patients with RA A proof-of-concept study to explore safety and tolerability, pharmacokinetic...

Ngày tải lên: 09/08/2014, 10:23

... Health Research and Care for Leicestershire, Northamptonshire and Rutland (NIHR CLAHRC for LNR)Figure 1 The translation model of National Institute for Health Research Collaboration for Leadership ... develop and investigate methods of translating research evidence into practice. Given the title Collaborations for Leadership in Applied...

Ngày tải lên: 11/08/2014, 05:21

... as: Medhin et al., The effect of maternal common mental disorders on infant undernutrition in Butajira, Ethiopia: The P-MaMiE study BMC Psychiatry 2010, 10:32 Medhin et al. BMC Psychiatry 2010, ... never/antenatal only/ incident postnatal/chronic). None of the findings showed statistically significant effect of CMD on nutritional sta- tus of infants...

Ngày tải lên: 11/08/2014, 16:22

... in sales of TCAs being associated with a decline in the suicide rates in the Nordic countries in the period 1990-98. We did not find any inverse relationship between the increase in sales of ... and suicide rates per se. The decline in the suicide rates in Denmark and Sweden pre-dated the introduction of SSRIs by ten years or more,...

Ngày tải lên: 11/08/2014, 16:22

... use the preliminary safety data from t he current study to investigate safety and efficacy over a longer duration, or using other dosing regimens. In summary, we show that the inhaled PDE4 inhibitor GSK256066 ... drug directly to the t arget organ to increase therapeutic effects. GSK256066 (6-({3- [(dimethylamino) carbonyl] phenyl}sulfonyl)-8-methyl -4- { [3-methyloxy)phenyl]...

Ngày tải lên: 12/08/2014, 11:20

... that IL-8 may be involved in the airway hyperresponsiveness of CF by increasing smooth muscle contraction. Consistent with this hypothesis, we have demonstrated that ASM from healthy individuals expresses ... suggest that the bronchial responsiveness observed in CF may be related to an increase in airway smooth muscle (ASM) contraction. Many inflammatory cytokines a...

Ngày tải lên: 12/08/2014, 14:20

... are cross-linking amino acids which are present only in mature elastin. Changes in their concentration in body fluids indicate changes in elastin degradation and can be a reflection of tissue ... com- ponent in urine[5]. The use of these markers of lung elastin degradation in disease offers the prospect of evaluating levels of D/I as indicators of possible e...

Ngày tải lên: 12/08/2014, 14:20