Báo cáo y học: "Nicotine enhances murine airway contractile responses to kinin receptor agonists via activation of JNK- and PDE4-related intracellular pathways" pdf
Báo cáo y học: "Nicotine enhances murine airway contractile responses to kinin receptor agonists via activation of JNK- and PDE4-related intracellular pathways" pdf
... Nicotine enhances murine airway contractile responses to kinin receptor agonists via activation of JNK- and PDE4-related intracellular pathways. Respiratory Research 2010 11:13. Submit your next ... des-Arg 9 -bradykinin and bradykinin. Conclusions: Nicotine induces airway hyperresponsiveness via transcriptional up-regulation of airway kinin B 1 an...
Ngày tải lên: 12/08/2014, 11:20
Báo cáo y học: "The S100A8/A9 heterodimer amplifies proinflammatory cytokine production by macrophages via activation of nuclear factor kappa B and p38 mitogen-activated protein kinase in rheumatoid arthritis" potx
... levels Conclusion In summary, the S100A8/A9 heterodimer, highly expressed by synovial lining macrophage, may play a role in amplifying proin- flammatory cytokine responses via activation of NF-κB and p38 MAPK ... inflammatory cells, primarily lym- phocytes, and macrophages and proliferation of synovial fibroblasts, together with increased vascularity. Macrophages play a critic...
Ngày tải lên: 09/08/2014, 07:20
Báo cáo y học: " PCEP enhances IgA mucosal immune responses in mice following different immunization routes with influenza virus antigens" pdf
... the newer polyphosphazene polyacids, poly[di(sodiumcarboxyla- toethylphenoxy)phosphazene] (PCEP) has been shown to be more potent than PCPP in terms of quantity and quality of immune responses [13,15]. ... SA, Payne LG: Synthesis, physico-chemical properties and immunoadjuvant activity of water-soluble phosphazene polyacids. J Bioact and Compat Polymers 1998, 13:243-256. 17. A...
Ngày tải lên: 11/08/2014, 08:21
Báo cáo y học: "CD14 mediates the innate immune responses to arthritopathogenic peptidoglycan–polysaccharide complexes of Gram-positive bacterial cell walls" docx
... previously described in this model [22] (i.e. the infiltration of inflammatory cells into the syn- ovium, synovial hyperplasia, and fibrinous deposits; Fig. 5a). Infiltration of inflammatory cells ... persistence of PG-PS in the host [2]. The primary events and the identity of cellular receptors that mediate the innate immune response to and the arthritogenic properties of p...
Ngày tải lên: 09/08/2014, 01:23
Báo cáo y học: "B cells from rheumatoid arthritis patients show important alterations in the expression of CD86 and FcgRIIb, which are modulated by anti-tumor necrosis factor therapy" potx
... FcgRIIa and FcgRIIb on human monocytes are differentially regulated by Th1/Th2 cytokines, with interferon-gamma favoring the activator receptor and interleukin-4 favoring the inhibitory receptor ... of this receptor on B lymphocytes. In regard to RA, exposure o f DCs to synovial fluid from RA patients has been shown to lead to an upregulation of FcgRIIb [14] and an ele...
Ngày tải lên: 12/08/2014, 12:20
Báo cáo y học: "Elevated calcitonin precursor levels are related to mortality in an animal model of sepsis" pps
... possess regulatory mechanisms limiting the expression of ProCT mRNA; these inhibitory mechanisms may be deregulated by unusually high levels of inflamma- tory mediators. Stimulation of synthesis in ... peptides are released into the central circulation and may act systemi- cally, as opposed to many of the known mediators of sepsis, which are released locally and often act in a...
Ngày tải lên: 12/08/2014, 18:20
Báo cáo y học: "Mutation in the loop C-terminal to the cyclophilin A binding site of HIV-1 capsid protein disrupts proper virus assembly and infectivity" ppt
... or infectivity [4-8] and the infectivity of HIV-1 is critically dependent on proper CA assembly and disassembly following cell entry [9]. Although much of the assembly properties of HIV-1 CA were ... electron microscopy analysis of E98A and wild-type NL4-3 viri- ons. The data represents detailed numerical analysis of 798 mutant E98A and 373 wild-type HIV-1 particle morpholog...
Ngày tải lên: 13/08/2014, 09:20
Báo cáo y học: "Methotrexate enhances the anti-inflammatory effect of CF101 via up-regulation of the A3 adenosine receptor expression" doc
... study the legs were removed up to the knees, fixed in 10% formaldehyde, decalcified, dehydrated, paraffin embedded and cut into 4 μm sections. They were then stained by haematoxylin and eosin, and ... where it is known to exert its anti- inflammatory effect via suppression of inflammatory cytokines such as tumour necrosis factor (TNF)-α, interleukin-6, or mac- rophage inhibitory...
Ngày tải lên: 09/08/2014, 08:23
Báo cáo y học: "Neurturin enhances the recovery of erectile function following bilateral cavernous nerve crush injury in the rat" ppsx
... shown to promote survival and maintainence of cra- nial parasympathetic neurons via a Ret receptor tyrosine- kinase signalling component and a glycosylphosphati- dylinositol-anchored GDNF family receptor ... Urology Laboratory and Department of Urology, University of California, San Francisco, USA and 2 Rinat Neuroscience, South San Francisco, USA Email: Anthony J Bell...
Ngày tải lên: 10/08/2014, 09:22
Báo cáo y học: "Levamizole enhances immune responsiveness to intra-dermal and intra-muscular hepatitis B vaccination in chronic hemodialysis patients" pps
... infections among these patients is due to immunodeficiency status manifested by abnormal phagocytosis, T and B-lymphocyte abnormali- ties, and impaired responses to T cell dependent patho- gens such ... of the symptoms were relived by continu- ing of the drug and did not relapse at the succeeding courses of Levamisole in. Discussion In our hemodialysis patients, antibody res...
Ngày tải lên: 11/08/2014, 10:23