... H, Hasegawa M, Sugai S, Obata T, Ugi S, Morino K, Egawa K,Fujita T, Sakamoto T, Nishio Y, Kojima H, Haneda M, Yasuda H, Kikkawa R,Kashiwagi A: Expression of a dominant negative SHP -2 in transgenicmice ... its phospha-tase activity. In addition to its phosphatase activity,SHP -2 appears to function as a molecular adaptor asshown by Ali et al’sreportofaSHP-2IRScomplex[7]as well as its adaptor function ... cytokine-inducedsignaling and cellular response. Biochim Biophys Acta 20 02, 15 92: 29 7-3 01. 25 . Wang Q, Downey GP, Herrera-Abreu MT, Kapus A, McCulloch CA: SHP -2 modulates interleukin-1-induced Ca2+...