báo cáo khoa học: " Insight into the early steps of root hair formation revealed by the procuste1 cellulose synthase mutant of Arabidopsis thaliana" doc
báo cáo khoa học: " Insight into the early steps of root hair formation revealed by the procuste1 cellulose synthase mutant of Arabidopsis thaliana" doc
... Plant Biology Open Access Research article Insight into the early steps of root hair formation revealed by the procuste1 cellulose synthase mutant of Arabidopsis thaliana Sunil K Singh 1,4 , Urs ... B Localisation of root hair formation is altered in the prc1-1 mutantFigure 3 Localisation of root hair formation is altered in the prc1-1...
Ngày tải lên: 12/08/2014, 05:20
Báo cáo khóa học: Insight into the activation mechanism of Bordetella pertussis adenylate cyclase by calmodulin using fluorescence spectroscopy pptx
... direct exploitation of the structural results of the former to explain the mechanism of CaM activation of the latter. Crystallization and resolution of the 3D structures of AC and AC–CaM, which ... and therefore provides information mainly on the dynamics of this region of the protein. This residue is probably widely accessible to the solvent in AC as shown by...
Ngày tải lên: 07/03/2014, 15:20
Báo cáo khoa học: Insight into the phosphodiesterase mechanism from combined QM ⁄ MM free energy simulations pot
... with other residues (Fig. 1). The hydrogen atoms of H 2 O2 form hydrogen bonds with the side chain of Glu304 and the backbone of Thr345. Interestingly, the side chain of Thr345, together with the ... to model the hydrolysis of cAMP by the enzyme PDE4B, which provides further insights on the general features of phosphate hydrolysis. The PDE superfamily of enzy...
Ngày tải lên: 14/03/2014, 23:20
Báo cáo khoa học: Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans ppt
... in soft agar by increasing the expression of the cyclin-depen- dent kinase inhibitor p21 WAF1 [72]. Again, similar to decorin, these growth inhibitory effects of lumican occur in a variety of ... prostate carcinoma generated by a targeted deletion of the tumor suppressor PTEN in the prostate, systemic delivery of decorin causes a marked downregulation of the EGFR in...
Ngày tải lên: 15/03/2014, 23:20
Tài liệu Báo cáo khoa học: Insights into the structure of plant a-type phospholipase D Susanne Stumpe, Stephan Konig and Renate Ulbrich-Hofmann ¨ ppt
... [20,21]. In the present study, the first insights into the secon- dary and tertiary structure of PLD a2 from cabbage are given. The surface structure of the enzyme was investigated by small-angle ... confirmed by the calculation of the a-helix and b-strand contents of the protein with the online programs dichroweb [25] and k2d [26], respectively. The well-struc...
Ngày tải lên: 19/02/2014, 02:20
Tài liệu Báo cáo khoa học: nsights into the reaction mechanism of glycosyl hydrolase family 49 Site-directed mutagenesis and substrate preference of isopullulanase doc
... is composed of residues 25–540. The overall structure of the model of IPU and the mutated residues in this study are shown in Fig. 3. To elucidate the mechanism of the substrate recognition of IPU, ... activating the nucleophilic water m olecule) in the first step of the reaction. A carbonium ion intermediate subsequently forms, and is further attacked by the wa...
Ngày tải lên: 19/02/2014, 16:20
Tài liệu Báo cáo khoa học: Insights into the interaction of human arginase II with substrate and manganese ions by site-directed mutagenesis and kinetic studies Alteration of substrate specificity by replacement of Asn149 with Asp docx
... as a consequence of the mutagenic replacements. Effects of the His120Asn and His145Asn mutations on the affinity of metal binding to arginase II To further examine the effects of the His120fiAsn and ... produced by agmatine hydrolysis, in studying the inhibitory effect of agmatine on arginine hydrolysis, reactions were followed by measuring the formation of ornit...
Ngày tải lên: 20/02/2014, 02:21
Báo cáo khoa học: Insights into substrate and product traffic in the Drosophila melanogaster acetylcholinesterase active site gorge by enlarging a back channel ppt
... analysis of initial rate data in the absence of inhibitors, we used the specific equation in Scheme 1. The effect of two ligands on the activity of the wild-type DmAChE was evaluated by the equation ... substrate entrance. Thus, in the wild-type, the channel is so narrow that the ‘back door’ is used by at most 5% of the traffic, with the majority of traffic...
Ngày tải lên: 07/03/2014, 05:20
Báo cáo khoa học: Investigations into the ability of an oblique a-helical template to provide the basis for design of an antimicrobial anionic amphiphilic peptide pot
... hypo- thesis of Tytler et al. [48], it may be that insertion of the inverted wedge shape formed by the AP1 a-helix into membranes of E. coli leads to the formation of nonbilayer structures and thereby ... pressure of the monolayer, and A represents the area per molecule in the monolayer. The Gibbs free energy of mixing (DG Mix ) quantifies the sta- bility of...
Ngày tải lên: 07/03/2014, 12:20
Báo cáo khoa học: Insights into the activation of brain serine racemase by the multi-PDZ domain glutamate receptor interacting protein, divalent cations and ATP ppt
... together with PDZ7. Interestingly, in the absence of additional ATP, the activation induced by the presence of the PDZ4- PDZ5-PDZ6-GAP2-PDZ7-end of GRIP reached the highest value. The conformational ... carbonyl groups. Both the geometry and the distances perfectly agree with the coordination of these metals [23]. The Fig. 4. Binding of ATP to SR changes the...
Ngày tải lên: 30/03/2014, 03:20