Toxicological Risk Assessment of Chemicals: A Practical Guide - Chapter 9 (end) ppt
Toxicological Risk Assessment of Chemicals: A Practical Guide - Chapter 9 (end) ppt
... 2004. U.S. EPA Air Toxics Risk Assessment Reference Library. Technical Resource Manual. EPA-453-K-0 4-0 0 1A. April 2004. Research Triangle Park, NC: Of fice of Air Quality Planning and Standards.http:==www.epa.gov=ttn=fera =risk_ atra_vol1.htmlUS-EPA. ... programs.US-EPA refers to chemi cals that cause serious health and environmental hazards as hazardousair pollutants (HAPs) or air toxics. The 197 0 Clean Air Act gave US-EPA authority to list air toxicsfor ... by Taylor & Francis Group, LLC. 9. 2.2.1 AirThe Clean Air Act (CAA), amended in 197 0 and in 199 0 (US-EPA 199 0), is the federal law underwhich the US-EPA sets limits for air pollutants anywhere...
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Toxicological Risk Assessment of Chemicals: A Practical Guide - Chapter 1 ppt
... Tests4 .9. 4 Guidance Documents4 .9. 4.1 WHO4 .9. 4.2 OECD4 .9. 4.3 US-EPA4 .9. 4.4 EU4 .9. 4.5 IARC4 .9. 5 Use of Information on Carcinogenicity in Hazard Assessment 4 .9. 5.1 Human Data4 .9. 5.2 Animal Data4 .9. 5.3 ... Grete. Toxicological Risk Assessment of Chemicals : a practical guide / Elsa Nielsen, Grete Ostergaard, and John Christian Larsen.p. ; cm.Includes bibliographical references and index.ISBN-13: 97 8-0 -8 49 3-7 26 5-0 ... ChemicalsHQ Hazard QuotientHR Heart RateHSDB Hazardous Substances Data BankHSG Health and Safety Guide IARC International Agency for Research on CancerICCVAM United States Interagency Coordinating...
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Toxicological Risk Assessment of Chemicals: A Practical Guide - Chapter 5 potx
... evaluation of the available data on default assessment factors was that the conventionally used factor of 100 (10 for animal-to-human and10 for human-to- human variations) is probably an underestimate. ... is stated that it is likely that theanimal-to-human extrapolation is greatly underestimated, and in the case of human-to-humanvariability, an assessment factor of 10–16 is considered as a minimum.Attention ... plasma concentration–time curve (AUC)). The analyses of human variability assessedcritically the adequacy of the general 3.16-fold toxicokinetic default factor, and calculated sets of pathway-related...
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Toxicological Risk Assessment of Chemicals: A Practical Guide - Chapter 7 ppsx
... Ministry of Health and Welfare ( 199 2 - cited in US-EPA 199 7).cFrom Ershow et al. ( 199 1 - cited in US-EPA 199 7).dFrom McNall and Schlegal ( 196 8 - cited in US-EPA 199 7).eFrom U.S. Army ( 198 3 - cited ... Handbook, National Center for Environmental Assessment, Washington, DC, 199 7. Available at http:== www.epa.gov=ncea=efh a From Ershow and Cantor ( 198 9 - cited in US-EPA 199 7).bFrom Canadian ... value is the popula tion-weighte d mean of the two nati onal studies (Ershow and Cantor 198 9 and Canadian Minist ry of Health and Welf are 198 1 - b oth cite d in US-EPA 199 7). The average of...
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SAFE USE OF CHEMICALS: A Practical Guide - Chapter 9 doc
... Press; Anger, W. K. 198 4. Neurobehavioral Toxicology and Teratol-ogy 6: 147–153.© 20 09 by Taylor & Francis Group, LLC180 Safe Use of Chemicals: A Practical Guide 9. 9 NEUROTOXICANTS AND NEONATESOccupational ... et al. 199 8. Risk of congenital anomalies near hazardous-waste landll sites in Europe: The EUROHAZCON study. Lancet Aug. 8: 423–427.© 20 09 by Taylor & Francis Group, LLCChemical Substances ... (paresthesia); loss of coordination; convulsion; and fatal injury. The toxicological data on the neurotoxic potential of a large number of chemical substances in daily use has not been adequately...
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SAFE USE OF CHEMICALS: A Practical Guide - Chapter 11 (end) pdf
... chemical substance injected into an artery of an animal or a humanIntra-aural: Any chemical substance placed into the ear of an animal or a humanIntracerebral: Any chemical substance injected ... the brain of an animal or a humanIntracervical: Any chemical substance placed in the cervixIntraduodenal: Any chemical substance injected into the small intestine of an ani-mal and a humanIntramuscular: ... humanIntramuscular: Any chemical substance injected into a muscle of an animal or a humanIntraperitoneal: Any chemical substance injected into the abdominal cavity of an animal or a human© 2009...
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SAFE USE OF CHEMICALS: A Practical Guide - Chapter 1 pot
... technical specialist for Standards Australia Quality Assurance Services (SAQAS) and he is responsible for quality management of the laboratory and good laboratory practices at Lloyd Register Quality ... Guidelines 193 Minimize Exposure and Reduce Risks 194 Hygiene and Chemical Safety 194 Glossary 197 Appendices 223© 20 09 by Taylor & Francis Group, LLC4 Safe Use of Chemicals: A Practical Guide as ... deep sense of appreciation to Narasimha Kramadhati, Pratibha Narasimha, Deepak Murthy, and Prerana Murthy for their active coopera-tion and for sharing thoughts about the book. With pleasure I...
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SAFE USE OF CHEMICALS: A Practical Guide - Chapter 2 pdf
... Press.15. Warren, P. 199 7. Hazardous gases and fumes A safety handbook. Amsterdam: Elsevier.16. National Institute for Occupational Safety and Health (NIOSH). 199 2. Recommenda-tions for occupational ... organic halides, esters, and many © 20 09 by Taylor & Francis Group, LLC6 Safe Use of Chemicals: A Practical Guide uses, manner of exposure, health effects, and environmental impact of different ... to many of the heavy metals has been associated with human cancer. Many toxic heavy metals (e.g., lead, manganese, and cadmium), combined with prenatal or neonatal developmental insults and...
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SAFE USE OF CHEMICALS: A Practical Guide - Chapter 3 pot
... OCED.6. National Research Council. 199 5. Prudent practices in the laboratory: Handling and disposal of chemicals. Ottawa, Ontario, Canada: National Research Council.7. Occupational Safety and Health ... manufactured nanomaterials, and their fate and transport. Risk assessment also includes studies © 20 09 by Taylor & Francis Group, LLC16 Safe Use of Chemicals: A Practical Guide the nature of ... safety data and detailed quality evaluations. To generate quality data about the candidate chemi-cal substance, different countries and international regulatory agencies have framed elaborate...
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SAFE USE OF CHEMICALS: A Practical Guide - Chapter 4 pdf
... ppm averaged over an 8-hour work shift.38, 39 n-Butylamine (CAS no. 10 9- 7 3 -9 )Molecular formula: C4H 9 NH2Synonyms and trade names: 1-aminobutane, 1-butanamine, butylamine, mono-n-butylamine ... vertigo, headache, anorexia, stom-ach pains, nausea, vomiting, irritation of the upper respiratory passages, coma, and death. 1,4-Dioxane also caused hepatic and renal lesions, demy-elination, and ... U.S. Department of Health and Human Services. Hazardous substances data bank (HSDB). 199 3. Online database. Bethesda, MD: National Toxicology Information Pro-gram, National Library of Medicine.23....
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