Toxicological Risk Assessment of Chemicals: A Practical Guide - Chapter 5 potx

... evaluation of the available data on default assessment factors was that the conventionally used factor of 100 (10 for animal-to-human and 10 for human-to- human variations) is probably an underestimate. ... is stated that it is likely that the animal-to-human extrapolation is greatly underestimated, and in the case of human-to-human variability, an assessment factor of 10–16 is co...

Ngày tải lên: 12/08/2014, 04:22

... Tests 4 .5. 3.2 In Vitro Tests 4 .5. 4 Guidance Documents 4 .5. 5 Use of Information on Irritation and Corrosion in Hazard Assessment 4 .5. 5.1 Human Data 4 .5. 5.2 Animal Data 4 .5. 5.3 In Vitro Data 4 .5. 5.4 ... Kalberlah and Schneider Approach 5. 2.1.9 UK Approach 5. 2.1.10 Swedish National Chemicals Inspectorate’s Approach 5. 2.1.11 Danish EPA’s Approach 5. 2.1.12 Chemical-Specifi...

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... ifferences can have a great impa ct on the risk charact erization (Chapte r 8) as well as on the development of regul atory stand ards and health-bas ed guidance values (Chapte r 9), and it is ... measurement of background levels, establishment and use of quality assurance and quality control measures, and selection and validation of analytical methods are important considerations...

Ngày tải lên: 12/08/2014, 04:22

... 2004. U.S. EPA Air Toxics Risk Assessment Reference Library. Technical Resource Manual. EPA- 453 -K-0 4-0 0 1A. April 2004. Research Triangle Park, NC: Of fice of Air Quality Planning and Standards. http:==www.epa.gov=ttn=fera =risk_ atra_vol1.html US-EPA. ... US-EPA appli es a risk- based approach to assess how these technology-based emission limits are reducing health and envir...

Ngày tải lên: 12/08/2014, 04:22

... by Taylor & Francis Group, LLC 86 Safe Use of Chemicals: A Practical Guide Inorganic arsenic compounds (As +3 and As +5 ) cause ulceration of nasal sep- tum, nasal septum perforation (as ... Safe Use of Chemicals: A Practical Guide 18. Ganapati, M. 2000. Half of Bangladesh population at risk of arsenic poisoning. British Medical Journal 320: 822. 19. Agency...

Ngày tải lên: 18/06/2014, 22:20

... technical specialist for Standards Australia Quality Assurance Services (SAQAS) and he is responsible for quality management of the laboratory and good laboratory practices at Lloyd Register Quality ... deep sense of appreciation to Narasimha Kramadhati, Pratibha Narasimha, Deepak Murthy, and Prerana Murthy for their active coopera- tion and for sharing thoughts about the book. With ple...

Ngày tải lên: 18/06/2014, 22:20

... organic halides, esters, and many © 2009 by Taylor & Francis Group, LLC 6 Safe Use of Chemicals: A Practical Guide uses, manner of exposure, health effects, and environmental impact of different ... to arsenic, beryllium, cadmium, hexavalent chromium, lead, and mercury. Contamination of food, water, and the air by met- als, particularly lead and cadmium, has caused globa...

Ngày tải lên: 18/06/2014, 22:20

... OCED. 6. National Research Council. 19 95. Prudent practices in the laboratory: Handling and disposal of chemicals. Ottawa, Ontario, Canada: National Research Council. 7. Occupational Safety and Health ... manufactured nanomaterials, and their fate and transport. Risk assessment also includes studies © 2009 by Taylor & Francis Group, LLC 16 Safe Use of Chemicals: A Practic...

Ngày tải lên: 18/06/2014, 22:20

... brain. 1–4,46–48 1,4-Dioxane and cancer: Laboratory studies with animals exposed to 1,4-diox- ane showed induction of nasal cavity and liver carcinomas in rats, liver carcinomas in mice, and gall bladder carcinomas ... and management of chemical substances, particularly hazardous wastes, require par- ticular training. Initial and refresher training are a must for all workers to protec...

Ngày tải lên: 18/06/2014, 22:20

... Safe Use of Chemicals: A Practical Guide sustainable and environmentally sound agricultural practices that reduce health and environmental risks associated with the use of pesticides. It is of ... and management of pesticides have caused untold health hazards to animals and humans and to the living environment © 2009 by Taylor & Francis Group, LLC 136 Safe Use of Che...

Ngày tải lên: 18/06/2014, 22:20