Toxicological Risk Assessment of Chemicals: A Practical Guide - Chapter 1 ppt

... Dutch Approaches 5.2 .1. 8 Kalberlah and Schneider Approach 5.2 .1. 9 UK Approach 5.2 .1. 10 Swedish National Chemicals Inspectorate’s Approach 5.2 .1. 11 Danish EPA’s Approach 5.2 .1. 12 Chemical-Specific Assessment ... Approaches 5.2 .1. 1 US-EPA Approach 5.2 .1. 2 Calabrese and Gilbert Approach 5.2 .1. 3 Renwick Approach 5.2 .1. 4 Lewis–Lynch–Nikiforov Approach 5.2 .1. 5 EU TGD Approach...

Ngày tải lên: 12/08/2014, 04:22

... that the animal-to-human extrapolation is greatly underestimated, and in the case of human-to-human variability, an assessment factor of 10 16 is considered as a minimum. Attention is also drawn ... data on default assessment factors was that the conventionally used factor of 10 0 (10 for animal-to-human and 10 for human-to- human variations) is probably an underestimate. It is...

Ngày tải lên: 12/08/2014, 04:22

... 7.32 18 .3 12 14 50 15 8. 71 19 .16 15 18 66 17 10 . 31 21. 65 19 –22 74 16 10 . 21 19.4 23–34 79 16 10 .62 19 .12 35–50 82 15 10 .25 18 .45 51 64 80 15 10 .11 17 .19 65–74 76 13 8.34 15 . 01 Over 75 71 13 8.02 15 .24 Lifetime ... m 3 =day 6– 8 years 10 m 3 =day 9– 11 years male=female 14 =13 m 3 =day 12 14 years male=female 15 =12 m 3 =day 15 18 years male=...

Ngày tải lên: 12/08/2014, 04:22

... 2004. U.S. EPA Air Toxics Risk Assessment Reference Library. Technical Resource Manual. EPA- 453-K-0 4-0 0 1A. April 2004. Research Triangle Park, NC: Of fice of Air Quality Planning and Standards. http:==www.epa.gov=ttn=fera =risk_ atra_vol1.html US-EPA. ... programs. US-EPA refers to chemi cals that cause serious health and environmental hazards as hazardous air pollutants (HAPs) o...

Ngày tải lên: 12/08/2014, 04:22

... technical specialist for Standards Australia Quality Assurance Services (SAQAS) and he is responsible for quality management of the laboratory and good laboratory practices at Lloyd Register Quality ... Polyneuropathy 17 8 9.8 Encephalopathy 17 9 9.9 Neurotoxicants and Neonates 18 0 9 .10 Conclusion 18 0 References 18 1 Appendix 9 .1: Chemical Substances and Neurotoxicity 18 3 Chapt...

Ngày tải lên: 18/06/2014, 22:20

... page) © 2009 by Taylor & Francis Group, LLC 11 8 Safe Use of Chemicals: A Practical Guide sustainable and environmentally sound agricultural practices that reduce health and environmental ... and management of pesticides have caused untold health hazards to animals and humans and to the living environment © 2009 by Taylor & Francis Group, LLC 13 6 Safe Use of Chemi...

Ngày tải lên: 18/06/2014, 22:20

... Lymphangiosarcoma Epithelium Glandular Adenoma Adenocarcinoma Squamous Squamous cell papilloma Squamous cell carcinoma Transitional Transitional cell papilloma Transitional cell carcinoma Hematopoietic Bone marrow Not ... the likelihood of harm, the hazard and weight -of- evidence process embraced an analy- sis of all relevant biological information and emphasized understanding the agent...

Ngày tải lên: 18/06/2014, 22:20

... and health status. Pediatrics 89 (6 Pt 1) : 10 10 10 15. 14 . National Academy of Sciences. 19 87. Regulating pesticides in food: The Delaney para- dox. Washington, D.C.: National Academy Press. 15 . ... Safe Use of Chemicals: A Practical Guide 2.2 .10 CARCINOGENS, MUTAGENS, AND TERATOGENS Carcinogens are chemical substances capable of increasing the risk of cancer afte...

Ngày tải lên: 18/06/2014, 22:20

... manufactured nanomaterials, and their fate and transport. Risk assessment also includes studies © 2009 by Taylor & Francis Group, LLC 16 Safe Use of Chemicals: A Practical Guide the nature of ... importance of safety evaluation studies to achieve human health have been discussed © 2009 by Taylor & Francis Group, LLC 18 Safe Use of Chemicals: A Practical...

Ngày tải lên: 18/06/2014, 22:20

... carcino- gen in animals and the IARC has classied it as group 1 meaning a human carcinogen. 3 7a 1, 1b-Biphenyl (CAS no. 9 2-5 2-4 ) Molecular formula: C 12 H 10 Synonyms and trade names: diphenol, 1, 1bbiphenyl, ... isopropyl acetate Dimethyl sulfoxide pentane 1- Butanol methyl acetate Ethanol 1- pentanol 2-butanol 3-methyl -1 - butanol Ethyl acetate 1- propanol Butyl ac...

Ngày tải lên: 18/06/2014, 22:20