Toxicological Risk Assessment of Chemicals: A Practical Guide - Chapter 1 ppt
Toxicological Risk Assessment of Chemicals: A Practical Guide - Chapter 1 ppt
... Dutch Approaches5.2 .1. 8 Kalberlah and Schneider Approach5.2 .1. 9 UK Approach5.2 .1. 10 Swedish National Chemicals Inspectorate’s Approach5.2 .1. 11 Danish EPA’s Approach5.2 .1. 12 Chemical-Specific Assessment ... Approaches5.2 .1. 1 US-EPA Approach5.2 .1. 2 Calabrese and Gilbert Approach5.2 .1. 3 Renwick Approach5.2 .1. 4 Lewis–Lynch–Nikiforov Approach5.2 .1. 5 EU TGD Approach5.2 .1. 6 ECETOC Approach5.2 .1. 7 ... Volume Challenge Program2.3 .1. 5 New Chemicals2.3 .1. 6 Integrated Risk Information System2.3 .1. 7 Harmonization of US-EPA Risk Assessment 2.3 .1. 8 US-EPA Risk Assessment Guidelines2.3 .1. 9 US-EPA Test...
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Toxicological Risk Assessment of Chemicals: A Practical Guide - Chapter 5 potx
... that theanimal-to-human extrapolation is greatly underestimated, and in the case of human-to-humanvariability, an assessment factor of 10 16 is considered as a minimum.Attention is also drawn ... data on default assessment factors was that the conventionally used factor of 10 0 (10 for animal-to-human and 10 for human-to- human variations) is probably an underestimate. It is stated that ... 3–5Toxicodynamic 2.5 3 .16 3 3 .16 Occupational 33Route-to-routeDuration exposure 10 Subacute-to-subchronic 10 3Subacute-to-chronic 624Subchronic-to-chronic 10 2 10 8 10 LOAEL-to-NOAEL 10 10 3 1 3 10 10 Nature...
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Toxicological Risk Assessment of Chemicals: A Practical Guide - Chapter 7 ppsx
... 7.32 18 .3 12 14 50 15 8. 71 19 .16 15 18 66 17 10 . 31 21. 65 19 –22 74 16 10 . 21 19.423–34 79 16 10 .62 19 .12 35–50 82 15 10 .25 18 .45 51 64 80 15 10 .11 17 .19 65–74 76 13 8.34 15 . 01 Over 75 71 13 8.02 15 .24Lifetime ... m3=day6– 8 years 10 m3=day9– 11 years male=female 14 =13 m3=day 12 14 years male=female 15 =12 m3=day 15 18 years male=female 17 =12 m3=dayAdults (over 19 years)Men 15 .2 m3=dayWomen ... ReferenceUnder 1 0.30 0.65 Ershow and Cantor (19 89)Under 3 0. 61 1.50 Health and Welfare Canada (19 81) 3–5 0.87 1. 50 Health and Welfare Canada (19 81) 1 10 0.74 1. 29 Ershow and Cantor (19 89)6 17 1. 14 2.21...
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Toxicological Risk Assessment of Chemicals: A Practical Guide - Chapter 9 (end) ppt
... 2004. U.S. EPA Air Toxics Risk Assessment Reference Library. Technical Resource Manual. EPA-453-K-0 4-0 0 1A. April 2004. Research Triangle Park, NC: Of fice of Air Quality Planning and Standards.http:==www.epa.gov=ttn=fera =risk_ atra_vol1.htmlUS-EPA. ... programs.US-EPA refers to chemi cals that cause serious health and environmental hazards as hazardousair pollutants (HAPs) or air toxics. The 19 70 Clean Air Act gave US-EPA authority to list air toxicsfor ... US-EPA appli es a risk- based approach toassess how these technology-based emission limits are reducing health and environmental risks.Based on this assessment, US-EPA may implement additional...
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SAFE USE OF CHEMICALS: A Practical Guide - Chapter 1 pot
... technical specialist for Standards Australia Quality Assurance Services (SAQAS) and he is responsible for quality management of the laboratory and good laboratory practices at Lloyd Register Quality ... Polyneuropathy 17 89.8 Encephalopathy 17 99.9 Neurotoxicants and Neonates 18 09 .10 Conclusion 18 0References 18 1Appendix 9 .1: Chemical Substances and Neurotoxicity 18 3 Chapter 10 Chemical Substances and ... Nephrotoxicity 18 5 10 .1 Introduction 18 5 10 .2 Chemical Substances and Renal Injury 18 5 10 .3 Symptoms of Nephropathy 18 6 10 .4 Metals and Nephrotoxicity 18 8References 19 0Conclusions 19 1Chemical Safety Guidelines...
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SAFE USE OF CHEMICALS: A Practical Guide - Chapter 6 ppt
... page)© 2009 by Taylor & Francis Group, LLC 11 8 Safe Use of Chemicals: A Practical Guide sustainable and environmentally sound agricultural practices that reduce health and environmental ... and management of pesticides have caused untold health hazards to animals and humans and to the living environment © 2009 by Taylor & Francis Group, LLC 13 6 Safe Use of Chemicals: A Practical ... —Aldrin B2 3 3Amitraz C — —Amitrole B2 3 3Aniline a B2 3 —Aramite B2 — 2BAsulam C — —Atrazine — — 3© 2009 by Taylor & Francis Group, LLC 12 0 Safe Use of Chemicals: A Practical Guide For...
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SAFE USE OF CHEMICALS: A Practical Guide - Chapter 8 ppt
... LymphangiosarcomaEpitheliumGlandular Adenoma AdenocarcinomaSquamous Squamous cell papilloma Squamous cell carcinomaTransitional Transitional cell papilloma Transitional cell carcinomaHematopoieticBone marrow Not ... the likelihood of harm, the hazard and weight -of- evidence process embraced an analy-sis of all relevant biological information and emphasized understanding the agent’s mode of action in producing ... instances, the group expe-rienced excess risk but the causative agent was unknown or at least unproven, as in © 2009 by Taylor & Francis Group, LLC 17 2 Safe Use of Chemicals: A Practical Guide APPENDIX...
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SAFE USE OF CHEMICALS: A Practical Guide - Chapter 2 pdf
... and health status. Pediatrics89 (6 Pt 1) : 10 10 10 15. 14 . National Academy of Sciences. 19 87. Regulating pesticides in food: The Delaney para-dox. Washington, D.C.: National Academy Press. 15 . ... Safe Use of Chemicals: A Practical Guide 2.2 .10 CARCINOGENS, MUTAGENS, AND TERATOGENSCarcinogens are chemical substances capable of increasing the risk of cancer after prolonged periods of exposure. ... Substances and Categorization 11 TABLE 2 .1 Oxidizing Chemical Substances and AgentsAluminum nitrateAmmonium permanganateAmmonium perchlorate Potassium nitrateAmmonium persulfate Potassium persulfate...
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SAFE USE OF CHEMICALS: A Practical Guide - Chapter 3 pot
... manufactured nanomaterials, and their fate and transport. Risk assessment also includes studies © 2009 by Taylor & Francis Group, LLC 16 Safe Use of Chemicals: A Practical Guide the nature of ... importance of safety evaluation studies to achieve human health have been discussed © 2009 by Taylor & Francis Group, LLC 18 Safe Use of Chemicals: A Practical Guide clutching, crab-claw appearance ... OCED.6. National Research Council. 19 95. Prudent practices in the laboratory: Handling and disposal of chemicals. Ottawa, Ontario, Canada: National Research Council.7. Occupational Safety and Health...
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SAFE USE OF CHEMICALS: A Practical Guide - Chapter 4 pdf
... carcino-gen in animals and the IARC has classied it as group 1 meaning a human carcinogen.3 7a 1, 1b-Biphenyl (CAS no. 9 2-5 2-4 )Molecular formula: C 12 H 10 Synonyms and trade names: diphenol, 1, 1bbiphenyl, ... isopropyl acetate Dimethyl sulfoxide pentane 1- Butanol methyl acetate Ethanol 1- pentanol2-butanol 3-methyl -1 - butanol Ethyl acetate 1- propanolButyl acetate methylethylketone Ethyl ether 2-propanoltert-Butylmethyl ... renal lesions, demy-elination, and edema of the brain. 1 4,46–48 1, 4-Dioxane and cancer: Laboratory studies with animals exposed to 1, 4-diox-ane showed induction of nasal cavity and liver carcinomas...
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