Báo cáo khoa học: " The prM-independent packaging of pseudotyped Japanese encephalitis virus" potx

... *10 2 0 BioMed Central Page 1 of 6 (page number not for citation purposes) Virology Journal Open Access Short report The prM-independent packaging of pseudotyped Japanese encephalitis virus Hee Jung ... response. The formation of the flavivirus prM/E complex is followed by the cleavage of precursor membrane (prM) and membrane (M) protein by a cellular signalase. To t...

Ngày tải lên: 12/08/2014, 04:22

... helix 4 of the NTD of a neighboring subunit in the hexamer. Additional contacts involve helix 11 of the CTD and the C-terminal end of helix 7 of the NTD of the neigh- boring subunit. The NTD–CTD ... involved either in the assembly of the immature HIV-1 capsid, or in the reassembly of CA into a mature capsid. The detailed description of the structure a...

Ngày tải lên: 18/02/2014, 06:20

... which corresponds to the a-helix 7 of NTD. This region is important for the formation of CA hexamers [6]; there- fore, this peptide could inhibit the formation of the hexamers, and assembly of the HIV-1 ... [36]; the helices are in red, the b-sheets in yellow and the loops in green. The circle at the bottom of the figure indicates the region where the bindin...

Ngày tải lên: 18/02/2014, 06:20

... on the proteomics of the capsid protein, its influence on the packaging of nonviral molecules into HIV-1 virions and the subsequent role of the molecules themselves. These inter- actions and their ... nucleus AB V3 358 362 367 480 V1 V2 Fig. 4. Role of TRIM5a and homology model of its PRYSPRY domain. (A) The hypothesized role of TRIM5a in the HIV-1 viral life cycle....

Ngày tải lên: 07/03/2014, 00:20

... for other infections, and the absence of radiological signs of pulmonary congestion might have resulted in another fluid therapy regimen. We did not score for the clinical relevance of the unexpected presence ... involved in drafting the manuscript. MG participated in analysis and interpretation of the data and in drafting the manuscript. PS, JS and MV contributed to the...

Ngày tải lên: 25/10/2012, 10:39

... turns of the DNA double helix yields binding of the two or three NF-Y complexes on the same side of the DNA. Conservation of spacing is required for optimal pro- moter activity because changing the ... located upstream of the CDE-like site [46]. These observations and the fact that activation does not rely on CCAAT-boxes, NF-Y or Sp1 proteins, leave open the question...

Ngày tải lên: 16/02/2014, 09:20

... Furthermore, the pro-peptide of GDF-8 impairs interaction of the mature part with its receptors [16]. In the case of BMP-9, the pro-pep- tide appears not to alter significantly the activity of the mature ... biological function of the pro-form of bone morphogenetic protein-2 (BMP-2), a member of the transforming growth factor b (TGFb) ⁄ BLP superfamily. The role...

Ngày tải lên: 18/02/2014, 06:20

... present for the last four residues at the C-terminus. The stereochemistry of the model has been assessed using the program procheck [23]. Ninety per cent of the residues fall in the most favoured regions ... mol- ecules. When the R-factor decreased to a value of 0.27 at 2.0 A ˚ resolution, inspection of the electron density map in the enzyme active site clearly rev...

Ngày tải lên: 18/02/2014, 06:20

... into the chitinolytic poten- tial of L. lactis, the present results provide only the third example of the role of family 33 CBPs in the deg- radation of recalcitrant polysaccharides. Furthermore, the ... [10]. Although the occurrence of family 33 CBPs has been known for some time [23], the present results provide only the third demonstration of the accessory fu...

Ngày tải lên: 18/02/2014, 08:20

... e.g. the case of the association between the N-terminal region of the membrane-bound tyrosine kinase Lck with the cytoplasmic tail of the T-cell coreceptors CD4 or CD8 [37]. In solution, on the ... typical of disor- dered proteins. The content of secondary structure was estimated through deconvolution of the CD spectrum in the range 190–240 nm using several met...

Ngày tải lên: 18/02/2014, 16:20