... 9508 randomised trial. Lancet 2004,363:1665-1672.21. Aoyama H, Shirato H, Tago M, Nakagawa K, Toyoda T, Hatano K,Keniyo M, Oya N, Hirota S, Shioura H, Kunieda E, Inomata T, Hay-akawa K, Katoh ... dem-onstrated in table 3.DiscussionBrain metastases are the most common form intra cranialtumor accounting significantly more than one- half of brain tumors in adults. Because of advanced in the ... morbid-ity and mortality, and are the most common intracranialtumors in adults, occurring in approximately 10% to 30% of adult cancer patients [1]. The risk of developing brainmetastases varies according...