Báo cáo khoa học: "HIV-1 CRF 02 AG polymerase genes in Southern Ghana are mosaics of different 02 AG strains and the protease gene cannot infer subtypes" doc

... CRF 02 AG polymerase genes in Southern Ghana are mosaics of different 02 AG strains and the protease gene cannot infer subtypesKwamena W Sagoe*1, Magda Dwidar2, Theophilus K Adiku1 and ... Majority of the CRF 02_ AG sequences from Ghana were made up of fragments of several strains of CRF 02_ AG/ AG strains. The protease gene alone is not suitablefor phylogenetic analysis.Conclusion: The ... The polymerase genes of HIV-1 strains from Ghana are made up of recombinants of several CRF 02_ AG strains from Ghana, Senegal and Cameroon, but the clinical implications are unknown. Using the...

Báo cáo khoa học: Plant oxylipins: Plant responses to 12-oxo-phytodienoic acid are governed by its speciﬁc structural and functional properties ppt

... released from these lipids by lipases.Regardless of their origin, in both plants and animals,RES are engaged in the activation of a distinct set of mostly defense- and stress-related genes. Transcrip-tional ... explored. In conclusion, the results point to a scenario in which RES trigger both the regulation of a speciﬁccluster of genes and their own inactivation by a feed-back loop, inducing the expression ... 12-hydroxy analog of JA, and theirprecursors, for example, the biological active OPDA. The biosynthesis of JA, and activation of the interme-diates by generation of the corresponding CoA estersfor...

Báo cáo khoa học: "Gastric outlet obstruction due to adenocarcinoma in a patient with Ataxia-Telangiectasia syndrome: a case report and review of the literature" pdf

... understanding of this diseaseprocess and the role of the ATM gene in carcinogenesis.ConsentWritten informed consent was obtained from the legalguardian for publication of this case report and ... abnormal immunoglobu-lin levels and the development of gastric cancer in thosepatients in whom levels were checked, suggesting thatinjury to the gastrointestinal mucosa in the form of chronic gastritis ... risk of gastric carcinoma is also elevated in patients with other primary immune deficiencies suchas X-linked agammaglobulinemia, common variableHematoxylin and eosin stained sections of the...

Báo cáo khoa học: " Early observed transient prostate-specific antigen elevations on a pilot study of external beam radiation therapy and fractionated MRI guided High Dose Rate brachytherapy boost" doc

... failure, patients may con-sider salvage therapy, including additional local therapiesor hormone therapy.Regardless of the definition, elevations in the PSA that rise and subsequently fall without ... management therebyreducing both patient and physician anxiety.Competing interests The author(s) declare that they have no competing inter-ests.AcknowledgementsThis research was supported in ... confirm adequate perinealaccess and the absence of pubic arch interference. Adju-vant hormonal or experimental PSA vaccine therapy waspermitted at the discretion of the treating physician. Alleligible...

báo cáo khoa học: "Heterotopic ossification after patellar tendon repair in a man with trisomy 8 mosaicism: a case report and literature review" pptx

... throughout the literature review and writing process.Both authors have read and approved the final manuscript.Competing interests The authors declare that they have no competing interests.Received: ... repair and possible excision of the H O.During the operative repair, his patellar tendon wasfound to be avulsed off the inferior pole of his patella.A repair was accomplished by weaving sutures ... from the patient’s mother for publication of this case report and any accompanying images. A copy of the written con-sent is available for review by the Edi tor -in- Chief of thisjournal.Authors’...

Tài liệu Báo cáo khoa học: NirF is a periplasmic protein that binds d1 heme as part of its essential role in d1 heme biogenesis pdf

... to that in Asp141 of Met8P. The idea of NirF being a dehydrogenase is appealingbecause of the presence of a putative nucleotide-bind-ing motif in the N-terminal of the protein sequence and also ... NirF and the d1heme-bindingdomain of cytochrome cd1. Therefore, we tested for the binding of d1heme to puriﬁed NirF. The addition of d1heme to the NirF resulted in the appearance of adistinctive ... in loss of in vivoNirF activity. We demonstrate here that the product of the nirF gene is aperiplasmic protein and, hence, must be involved in a late stage of the cofac-tor biosynthesis. In...

Tài liệu Báo cáo khoa học: High-afﬁnity ligand binding by wild-type/mutant heteromeric complexes of the mannose pptx

... 4 °C. The lines in each graph (F, G) indicate the amount of binding predicted if the wild-type and mutant receptors are binding ligand independently. The tables indicate the amounts of the various ... that the percentage of binding based oncontributions of the mutant (no binding activity) and wild-type (100% binding activity) mini-receptors in the mixture would follow the line displayed in the ... respectively. The lines in each graph (E, F) indicate the amount of binding predicted if the wild-type and mutant receptors are binding ligand independently. The tables indicate the amounts of the various...

Tài liệu Báo cáo khoa học: 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5¢-phosphate synthases of fungi and archaea docx

... putative genes were of two types, either with the two-domain architecture of the RibG protein of Bacil-lus subtilis or the RibD protein of E. coli, respectively[18–20], or the single-domain type of ... overexpression of lac repressor protein. Kanamycin and ampicillin were used to secure the maintenance of bothplasmids in the host strain.Cloning of 2,5-diamino-6-ribitylamino-4(3H)-pyri-midinone 5¢-phosphate ... Nocardia farcinica,accession number Q5Z3S1], the reductase domain islocated at the N-terminus and the predicted deaminaseat the C-terminus of the bifunctional protein. In plants, orthologues of pyrimidine...

Tài liệu Báo cáo khoa học: DNA modiﬁcation with cisplatin affects sequence-speciﬁc DNA binding of p53 and p73 proteins in a target site-dependent manner pptx

... probability of formation of the cisplatinIACs within the p53DBSs due to the occurrence of the GG, AG and ⁄ or GNG motifs, the stronger the inhibition of the p53 sequence-speciﬁc DNA bindingto these ... withcisplatin on the binding of two p73 isoforms, p73d and p73b, to the p21 target site (Fig. 5). The intensity of the resulting R73dband decreased almost linearly withincrease in the cis-platination ... sequence-speciﬁc binding of the p53(1–363) protein to the 32P-labeled 50-mer targets resulted in the appearance of a distinct retarded band R53 in the polyacrylamide gel (Fig. 2). Binding of the p73bCisplatin...

Tài liệu Báo cáo khóa học: Point mutations associated with insecticide resistance in the Drosophila cytochrome P450 Cyp6a2 enable DDT metabolism doc

... of these theoretical modelswere validated by site-directed mutagenesis. The majority of the mutagenesis studies focused in the vicinity or inside the substrate recognition sites (SRS [31]). These ... B¢ and C, junction between b sheets 4–1 and 4–2) are very different from the locations of the mutatedpositions in CYP6A2 (helix J and vicinity of the b sheet 3–3).These results are also original ... thiscytochromeP450andpromptedustoaddressthespatialpositions of the mutations. According to the sequencesalignment, the amino acids R335 and L336 would be in the J helix and V476 near or in the b sheet 3–3. These...

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