Báo cáo y học: "Hepatitis C virus core, NS3, NS4B and NS5A are the major immunogenic proteins in humoral immunity in chronic HCV infection" potx

... neg- ative. The core, NS3, NS4B and NS5A proteins form the major immunogenic proteins of HCV virus The frequency of antibody responses against individual HCV proteins is shown in Fig. 3A. From the 68 HCV ... chronic HCV infectionFigure 3 The specificity of anti -HCV antibody responses in patients suffering from chronic HCV infection. A. The...

Ngày tải lên: 12/08/2014, 04:21

... C virus, in and of itself, can directly induce cytoplasmic lipid accumulation. Further studies examining the genotype 3 virus are warranted to further recognize the process involved in HCV- induced ... lipid accumulation within the hepatocyte. HCV core protein has been studied at length in both cell cultures and in transgenic mice. Intracellular lipid buildup...

Ngày tải lên: 02/11/2012, 09:51

... antiviral therapy. Virological tools include serological assays for anti -HCV antibody detection and serological determination of the HCV genotype, and molecular assays that detect and quantify HCV ... HCV RNA and determine the HCV genotype. Anti -HCV antibody testing and HCV RNA testing are used to diagnose acute and chronic hepatitis C. Only patients with...

Ngày tải lên: 02/11/2012, 09:56

... Ahmed 3 Abstract Hepatitis C virus (HCV) is the leading cause of chronic hepatitis worldwide and its subtypes/genotypes are clinically important for clinical management and vaccine development. The present study describes ... marker and the HCV genotype for each sample was confirmed by HCV genotype-specific PCR band. Gel documentation system (Geldoc System, Eppendorf I...

Ngày tải lên: 11/08/2014, 21:21

... IFN-a in Huh7 cells. The clinical significance of the inhibitory effect of MxA gene transcription by HBc protein requires further study. Introduction Many studies have indicated that hepatitis B virus (HBV) ... different characteristics in replication cycle in vitro compared to the wild-type strain [4-9]. Moreover, in vivo infection with full-length HBV strains carrying these...

Ngày tải lên: 12/08/2014, 01:22

... the majority had used non-injecting drugs, including the anti -HCV- positive individuals. The risk of HCV infection associated with non-injecting drugs is probably linked to the usual prac- tice ... donors and chronically infected patients. The HCV subtypes identified in the study population (1a, 1b, 2b and 3a) are also consistent with the subtypes circulating in B...

Ngày tải lên: 12/08/2014, 04:20

... Apoptotic features induced by the HCV core protein In order to characterize more precisely cell death induc- tion by the core protein we analyzed the reactivity of the UC cell line by different methods. ... cells cultured in the presence or absence of tetracycline to induce specific protein expressionFigure 3 Different features of apoptosis induced by the HCV- core protein...

Ngày tải lên: 12/08/2014, 04:21

... factors • Confidence in applying behaviour change • Perceived accessibility of support services Other criteria included • Clinician types not included in the baseline analysis • Clinicians reporting change 3 ... Health: Integrated Primary and Community Health Policy 2007- 2012 Sydney: NSW Health; 2006. 47. Charmaz K: Coding in Grounded Theory Practice. In Construct- ing Grounded...

Ngày tải lên: 11/08/2014, 05:21

... the combined effect of HBV and HCV coinfection on HCC? Accumulated epidemiological data suggested that coinfection with HBV and HCV could increase the risk for development of HCC. A case-control ... the prevalence and clinical significance of occult HBV infection in patients with chronic hepatitis C. The result showed that 21 of the 66 patients with HCV infect...

Ngày tải lên: 02/11/2012, 09:51