Báo cáo khoa học:" Protein intrinsic disorder and influenza virulence: the 1918 H1N1 and H5N1 viruses" docx

... molecules and increase the virulence of both the H5N1 and the 1918 H1N1 viruses. The results help explain many puzzling features of the H5N1 and the 1918 H1N1 viruses. Summarizing, HA (and especially ... era include the Spanish influenza (H1N1, 1918) , the Asian influenza (H2N2, 1958), and the Hong Kong influenza (H3N2, 1968) [3-6]. The human to...

Ngày tải lên: 12/08/2014, 04:21

... than the 1918 H1N1 and H5N1 have no pre- dicted disorder at the tip of the stalk. Examples of this behavior are H3N2 and the particular strain of H7N3. H9N2 and 1918 H1N1: masking the virulence The ... helix of the HA stalk (near the residues 68– 79, see Figures 1 and 2). This is the case for the 1918 H1N1 strain and for all the virulent samples...

Ngày tải lên: 12/08/2014, 04:21

... problems and follows the same basic folding rules in the cytosol and ER. The chaperones that assist the nascent chains in these two compartments are related: members of the Hsp70 fam- ily and their ... increase in protein synthesis can result in overload of the ER folding capacity and the accumulation of unfolded and mis- folded proteins. The ER contains sensors th...

Ngày tải lên: 07/03/2014, 06:20

... better than the reduced atom approach. The protein RNA score has distinctive properties compared to the protein DNA potential. When we scored the protein RNA decoy set using the protein S. Zheng ... of groups for the prediction of protein structures, protein DNA and protein ligand interactions [18–35], such an approach has never been applied to protein RNA interactions...

Ngày tải lên: 18/02/2014, 16:20

... hypotheses and significantly reducing the search space. Therefore the global structural synthesis capabilities of the unification grammar and the local relation estimation capabilities of the ... the unification grammar and the Markov language model will be integrated in the language model to obtain better results. The parsing strategy 1 uses the random select...

Ngày tải lên: 08/03/2014, 07:20

... containing the RNase III enzyme Drosha and the dsRNA-binding protein DGCR8, cleaves the pri-miRNA and exises a stem loop of  70 nucleotides [3–6]. This precursor miRNA (pre-miRNA) is then exported to the cytoplasm ... containing Argonaute proteins as well as Dicer and other factors [3]. One of the additional factors is TRBP, which together with Dicer facilitates generation...

Ngày tải lên: 16/03/2014, 06:20

... form the outside of the wedges. The wedge pockets have an extended seam that extends the length of the interface between these domains with the c-phosphate of bound ATP exposed at one end. On the ... activity by elevation of the NADH/NAD + and acetyl-CoA/CoA ratios. In the PDC reaction (forward direction proceeds in the counterclockwise direction), the rapid and reve...

Ngày tải lên: 17/03/2014, 09:20

... mem- brane and the photosynthetic thylakoid membranes) as well as three soluble subcompartments, the thylakoid lumen, the stroma and the intermembrane space. The large majority of chloroplast proteins ... [ 35 S]pTic22, [ 35 S]pMGD1 and [ 35 S]pSSU were added to the column in binding buffer and incubated for 45 min. The flow through after incubation (Ft), the third wash...

Ngày tải lên: 23/03/2014, 07:20

... XIs from the mesophiles E. coli (ECXI) and Bacillus licheniformis (BLXI), for the moderate thermophile Thermoanaerobacterium thermosulfurigenes (TTXI), and for the hyperthermophile Thermotoga neapolitana ... coli and Bacillus licheniformis), thermophilic (Thermoanaerobacterium thermosulfurigenes), and hyperther- mophilic (Thermotoga neapolitana) bacteria were examined. Unlike t...

Ngày tải lên: 23/03/2014, 13:20

... (A) and the control group (B). * ,† Significant differences (p ＜ 0.05, p ＜ 0.01) compared between the treated group and the control group on the same day. than those in the control group, the ... distributed in the ileum and pelvic flexure [16]. Therefore, it is suggested that the difference in the distribution of the 5HT 4 receptor is at the base of differe...

Ngày tải lên: 07/08/2014, 23:22