Báo cáo khoa học: "Small interference RNA profiling reveals the essential role of human membrane trafficking genes in mediating the infectious entry of dengue virus" pdf

... as: Ang et al.: Small interference RNA profiling reveals the essential role of human membrane trafficking genes in mediating the infectious entry of dengue virus. Virology Journal 2010 7 :24. Submit ... a detail profiling of the human membrane trafficking cellular genes and the mechanistic insight into the interplay of these host gene...

Ngày tải lên: 12/08/2014, 04:21

... blot. In vivo, the effect of TF-siRNA on the growth of A549 lung adenocarcinoma xenografts in nude mice was investigated. Results: TF -siRNA significantly reduced the expression of TF in the mRNA ... explore the role of TF in biological processes of lung adenocarcinoma, we used RNA interference (RNAi) technology to silence TF in a lung adenocarcinoma cell l...

Ngày tải lên: 10/08/2014, 10:21

... tubes suggesting a role for GABA in intercellular signaling [43]. β-Alanine is a non-protein amino acid synthesized mainly by polyamine (i.e. spermine and spermidine) degradation and involved in coenzyme ... benzylisoquinoline alkaloids, including the analgesics morphine and codeine, the muscle relaxant and vasodilator papaverine, the antineoplastic drug noscapine and the antimi...

Ngày tải lên: 12/08/2014, 05:20

... transcription initiation of genes, initiation of DNA replication and alternative splicing of exons. The small interference (si )RNA genes active in RNA interference comprise inverted repeats capable of forming ... within genes and tend to be located in large introns of long genes. The LIRs in the large introns, although still unstable, will not greatly distu...

Ngày tải lên: 07/03/2014, 00:20

... reticulum protein that blocks the processing of sterol regulatory element-binding proteins (SREBPs) by binding to SREBP cleavage-activating protein, thus preventing the latter from escorting SREBPs to the ... regulation, the blocked green lines indicate negative regulation, and the dashed lines indicate indirect inhibition. The black lines indicate substance conversion or transp...

Ngày tải lên: 16/03/2014, 04:20

... Mutations of these binding sites abolished not only binding of the Ets protein, but also the intrinsic promoter activity. Increased DNA-binding activity of Ets-1 ⁄ Elk-1 by v-Ha-ras also augmented the ... regulation of the gene. In this regard, we identified the region that plays an impor- tant role in determining the basal promoter activity of the gene. Furthermo...

Ngày tải lên: 29/03/2014, 09:20

... potential G-quadruplex-forming sequence element, containing several tracts of two consecutive guanines, within the promoter of human thymidine kinase 1 (TK1). Thymi- dine kinase is a critical enzyme required for the production ... change in the promoter activity of pTK1 suggests involvement of the G-quadruplex motif formed by TKQ1 in regulating TK1 expression. Inter- est...

Ngày tải lên: 29/03/2014, 21:20

... pseudo-first-order conditions using an excess of inhibitor at various molar ratios of hK14. The time-dependent inactivation of the enzyme by the serpin was monitored continu- ously, following the decrease in the rate of ... hK14, resulting mainly in accumulation of the cleaved form of the inhibitor rather than formation of the irreversible com- plex (data not...

Ngày tải lên: 30/03/2014, 11:20

... after the cap has been shed and in seeds [20,21]. All these results and current knowledge of the possible functions of the genes in the region confirmed the former hypothesis of Costantini et ... the manuscript. CH performed the sequence analysis of VvAGL11 in the Core Collection. AFAB coordinated and followed the experiments for the integrative mapping, pa...

Ngày tải lên: 11/08/2014, 11:21

... insight into the potential coordinators of this expression signature. Interestingly, FOXO trans- cription binding sites tended to be, if anything, significantly under-represented in the human ... promoters of the WL-associated genes (Figure S4 in Additional data file 3). e analysis further supports the idea that this list is distinct. Interestingly, the enriched TF...

Ngày tải lên: 11/08/2014, 12:20