Báo cáo y học: "A VLP-based vaccine targeting domain III of the West Nile virus E protein protects from lethal infection in mice" pptx

... in any medium, provided the original work is properly cited. Research A VLP-based vaccine targeting domain III of the West Nile virus E protein protects from lethal infection in mice Gunther ... Under these mildly reducing condi- tions the cysteine residue contained in the linker is reduced, while the internal disulfide bridge of DIII-C remains...

Ngày tải lên: 12/08/2014, 04:20

... on the cloning of the gene encoding the secreted CM from Yersinia pestis (*YpCM, y2 828), purification of the protein, investigation of the properties of the enzyme, and the crystal structure analysis ... after first online publication: in the preceding sentence, The gene y2 828 from the genome sequence of Y. pestis strain Kim10+ (21) as CM’ was corrected...

Ngày tải lên: 17/03/2014, 17:20

... have developed a chemical-genetics system to modulate the activity of a protein kinase by mutating an amino acid residue in its ATP-binding pocket (the ‘gate- keeper’ residue), allowing the resulting ... Ser824 are independent events, as no difference in the phosphorylation o f one site was observed when the other site was mutated (Figure 3d). Moreover, the DNA-damage induc...

Ngày tải lên: 09/08/2014, 23:20

... underwent the operation. All Authors read and approved the final manuscript. Competing interests The authors declare that they have no competing interests. Received: 31 July 2011 Accepted: 29 September ... localized fibrous tumor of the pleura. The left lung expanded completely and pulmonary function recovered to the normal level after removal of the giant tumor. The posto...

Ngày tải lên: 10/08/2014, 09:22

... propor- tionally to the threefold rise in the total number of markers, but the extension of the linkage maps remained relatively small, because of a higher marker density. The average dis- tance between the ... also increased the risk for false contigs because of a high density of repetitive sequences. Of the clones fingerprinted, we deleted 2,246 BACs during fin...

Ngày tải lên: 14/08/2014, 08:20

... subpopulation of CD11c+ cells displayed low uptake rates, the other one presented high uptake capacity. These values were similar when the cells were stimulated with either vaccine or vector. These results ... proinflamma- tory cytokines, whereas DCs are primarily involved in inducing antimycobacterial T cell immune response. Despite the fact that we studied the interaction of...

Ngày tải lên: 14/08/2014, 19:22

... selected. Selecting the reference sequence: regions of low similarity In low similarity regions the sequence of one allele was selected for the entirety of the region based on the following heuristics. If ... elements in the reference sequence or between the aligned haplomes. The mobile element content of the two reconstructed haplomes is similar to that of th...

Ngày tải lên: 14/08/2014, 20:22

... injected intracerebroventricularly, with at least three animals injected for each dose.Themicewereobservedfor24h,andeffectswereranked between 0 and 10, 0 being no e ect and 10 being lethality. The inter- mediate ... compared to Gly23 of birtoxin (Fig. 4). In ikitoxin the presence of Glu23 charge preceding the a-helix modifies the activity of this toxin in a unique way to resu...

Ngày tải lên: 31/03/2014, 08:20

... and the presence of the metabolic syndrome according to the definition usedThe relationship between methotrexate use and the presence of the metabolic syndrome according to the definition used. ... meth- otrexate use. Conversely, it could be explained in differences in the sensitivity and specificity of each definition. The use of the NCEP criteria in RA has be...

Ngày tải lên: 09/08/2014, 14:22

... many accessible regions in the genome are truly nucleosome-free. Whether other proteins that are bound to these regions or the underly- ing DNA sequence exclude nucleosomes in such regions remains ... the closest reference nucleosome to each measured nucleosome. The measured nucleosome then acquires the profile of the reference nucleosome, such as the associated genes and...

Ngày tải lên: 09/08/2014, 20:20