Báo cáo y học: "Caveolin-1 influences human influenza A virus (H1N1) multiplication in cell culture" docx

... antiviral targets we identified caveolin-1 (Cav-1) as a putative cellular interaction partner of human influenza A viruses, including the pandemic influenza A virus (H1N1) strains of swine origin ... knock-down as well as transfection of a dominant-negative Cav-1 mutant results in a decrease in virus titre in infected Madin-Darby canine kidney cells (MDCK),...

Ngày tải lên: 12/08/2014, 04:20

... S, Barclay W: Variation in the ability of human influenza A viruses to induce and inhibit the IFN-beta pathway. Virology 2006, 347:52-64. 29. Kurokawa M, Koyama AH, Yasuoka S, Adachi A: Influenza virus ... RESEA R C H Open Access Highly pathogenic avian influenza A virus H5N1 NS1 protein induces caspase-dependent apoptosis in human alveolar basal epithelial cells Chuanf...

Ngày tải lên: 12/08/2014, 04:20

... is highly conserved in all human influenza A strains. It is therefore an attractive target for preparation of a universal influenza A va ccine. In contrast to hemagglutinin and neuraminidase, eM2 ... date. Currently available vaccines induce antibodies against seasonal and closely related antigenic viral strains, but do not protect against antibody-escape var- iants of seasona...

Ngày tải lên: 12/08/2014, 02:20

... Dortmund, Germany). Structure calculation was performed using XPLOR 3.851 and a modified ab initio simulated annealing protocol including floating assignment of prochiral groups and a conformational database ... & Srinivasan, A. (1995) Muta- genesis of the putative alpha-helical domain of the Vpr protein of human immunodeficiency virus type 1: effect on stability and virion incorpora...

Ngày tải lên: 24/03/2014, 04:21

... data for a more easily accessible tissue such as skin for this exon array publicly available; however, one can extrapolate that adding cDNA from almost any tissue would be similarly beneficial ... Ensembl's transcript library are hypothetical and not confirmed to be expressed. A list of core exons as defined by the Affymetrix (Santa Clara, California, USA) Human Exon 1.0 ST Array w...

Ngày tải lên: 09/08/2014, 20:22

... post-infection. Cells were stained with a rabbit anti-NS1 polyclonal antibody and a mouse anti-NPM monoclonal antibody, revealed with a secondary FITC-labelled anti-rabbit antibody and a secondary RhodamineX-labelled anti-mouse ... strain (desig- nated Udorn), the human laboratory adapted influenza A/ PR/8/3 4(H1N1) strain (designated PR8), the avian influenza A/ Turkey/Ita...

Ngày tải lên: 12/08/2014, 04:20

... Chittaganpitch 3 , Sunthareeya Waicharoen 3 , Yuta Kanai 1,2 , Gui-Rong Bai 1,2 , Masanori Kameoka 1,2 , Naokazu Takeda 1,2 , Kazuyoshi Ikuta 1,2 and Pathom Sawanpanyalert 3 Abstract Since ... slowly in MDCK cells, producing small plaques. As indicated by lethality in embryonated eggs, viral RNA copy in allantoic fluid, and virus titer measured by plaque assay, our results demonstra...

Ngày tải lên: 12/08/2014, 04:20

... microscopically. The viability was determined using a cell viability assay for the nasal and throat swabs as well as for the nasal turbinates (Cell Titer Aqueous One Reagent, Promega). The lungs were analyzed ... preparation, VY: immunological analysis, SG: clinical pathology analysis, DN: virus preparation, CBJ: participated in design of study, review of findings and manuscript prep...

Ngày tải lên: 12/08/2014, 04:20

... drugs are available with antiviral activity against influenza viruses: the M2 inhibitors (amantadine and rimantadine), and the neuraminidase inhibitors (oseltamivir and zanamivir). Some currently circulating ... dingmeizhang@yahoo.com.cn; Yanbin Li - jiahailu@yahoo.com.cn; Bingyan Tan - gwzx@gzsums.edu.cn; Liping Ouyang - zjjouly@hotmail.com; Xinbing Yu - jiahailu@yahoo.com.cn * Correspond...

Ngày tải lên: 12/08/2014, 16:20

... b.asquith@imperial.ac.uk; Angelina J Mosley - angelina.mosley@imperial.ac.uk; Adrian Heaps - adrian.heaps@imperial.ac.uk; Yuetsu Tanaka - yuetsu@s4.dion.ne.jp; Graham P Taylor - g.p.taylor@imperial.ac.uk; ... interaction in human T lymphotropic virus I infection Becca Asquith* 1,2 , Angelina J Mosley 1 , Adrian Heaps 1 , Yuetsu Tanaka 3 , Graham P Taylor 4 , Angela R McLean 2 and Ch...

Ngày tải lên: 13/08/2014, 09:21