... antiviral targets we identified caveolin-1 (Cav-1) as a putative cellular
interaction partner of human influenza A viruses, including the pandemic influenza A virus (H1N1) strains of swine
origin ... knock-down as well as transfection
of a dominant-negative Cav-1 mutant results in a decrease in virus titre in infected Madin-Darby canine kidney cells
(MDCK),...
... S,
Barclay W: Variation in the ability of human influenza A viruses to induce
and inhibit the IFN-beta pathway. Virology 2006, 347:52-64.
29. Kurokawa M, Koyama AH, Yasuoka S, Adachi A: Influenza virus ... RESEA R C H Open Access
Highly pathogenic avian influenza A virus H5N1
NS1 protein induces caspase-dependent
apoptosis in human alveolar basal epithelial cells
Chuanf...
... is highly conserved in all human
influenza A strains. It is therefore an attractive target
for preparation of a universal influenza A va ccine. In
contrast to hemagglutinin and neuraminidase, eM2 ... date. Currently available vaccines induce antibodies
against seasonal and closely related antigenic viral
strains, but do not protect against antibody-escape var-
iants of seasona...
... Dortmund,
Germany). Structure calculation was performed using
XPLOR
3.851 and a modified ab initio simulated annealing
protocol including floating assignment of prochiral groups
and a conformational database ... & Srinivasan, A. (1995) Muta-
genesis of the putative alpha-helical domain of the Vpr protein of
human immunodeficiency virus type 1: effect on stability and
virion incorpora...
... data for a more easily accessible tissue such
as skin for this exon array publicly available; however, one
can extrapolate that adding cDNA from almost any tissue
would be similarly beneficial ... Ensembl's transcript library are
hypothetical and not confirmed to be expressed. A list of
core exons as defined by the Affymetrix (Santa Clara,
California, USA) Human Exon 1.0 ST Array w...
... post-infection. Cells were stained with a rabbit anti-NS1 polyclonal antibody
and a mouse anti-NPM monoclonal antibody, revealed with a secondary FITC-labelled anti-rabbit antibody and a secondary RhodamineX-labelled
anti-mouse ... strain (desig-
nated Udorn), the human laboratory adapted influenza
A/ PR/8/3 4(H1N1) strain (designated PR8), the avian
influenza A/ Turkey/Ita...
... microscopically. The viability was determined
using a cell viability assay for the nasal and throat swabs
as well as for the nasal turbinates (Cell Titer Aqueous
One Reagent, Promega). The lungs were analyzed ... preparation, VY: immunological analysis, SG: clinical
pathology analysis, DN: virus preparation, CBJ: participated in design of study,
review of findings and manuscript prep...
... drugs are available with antiviral
activity against influenza viruses: the M2 inhibitors
(amantadine and rimantadine), and the neuraminidase
inhibitors (oseltamivir and zanamivir). Some currently
circulating ... dingmeizhang@yahoo.com.cn; Yanbin Li - jiahailu@yahoo.com.cn;
Bingyan Tan - gwzx@gzsums.edu.cn; Liping Ouyang - zjjouly@hotmail.com; Xinbing Yu - jiahailu@yahoo.com.cn
* Correspond...
... b.asquith@imperial.ac.uk; Angelina J Mosley - angelina.mosley@imperial.ac.uk;
Adrian Heaps - adrian.heaps@imperial.ac.uk; Yuetsu Tanaka - yuetsu@s4.dion.ne.jp; Graham P Taylor - g.p.taylor@imperial.ac.uk; ... interaction in human T
lymphotropic virus I infection
Becca Asquith*
1,2
, Angelina J Mosley
1
, Adrian Heaps
1
, Yuetsu Tanaka
3
,
Graham P Taylor
4
, Angela R McLean
2
and Ch...