Báo cáo y học: " Effective inhibition of HCMV UL49 gene expression and viral replication by oligonucleotide external guide sequences and RNase P" pptx
Báo cáo y học: " Effective inhibition of HCMV UL49 gene expression and viral replication by oligonucleotide external guide sequences and RNase P" pptx
... properly cited. Research Effective inhibition of HCMV UL49 gene expression and viral replication by oligonucleotide external guide sequences and RNase P WenJun Zhang 1,2 , HongJian Li 1 , YueQin ... this article as: Zhang et al., Effective inhibition of HCMV UL49 gene expression and viral replication by oligonucleotide external guid...
Ngày tải lên: 12/08/2014, 04:20
Báo cáo y học: "Regional assessment of articular cartilage gene expression and small proteoglycan metabolism in an animal model of osteoarthritis" pptx
... OA chondrocytes synthesize SLRPs that are differently glyco- sylated, and that nonglycosylated biglycan and decorin are more abundant in OA cartilage [20]. Changes in glycosylation of the SLRPs, whether by ... meniscectomy). Changes in collagen subtypes in pathological cartilage may not only influence the biomechanical integrity of the tissue but may sequester and modulate the act...
Ngày tải lên: 09/08/2014, 06:23
Báo cáo y học: "Genomic analysis of metabolic pathway gene expression in mice" pps
... we used an analysis of over-represen- tation of gene set members by applying the Fisher's exact test, as implemented by the Expression Analysis Systematic Explorer (EASE) software [17]. The ... differentially regulated pathways identified by GSEA analysisFigure 1 Significantly differentially regulated pathways identified by GSEA analysis. The histogram represents the freq...
Ngày tải lên: 14/08/2014, 14:21
Báo cáo y học: "cGlobal analysis of microRNA target gene expression reveals the potential roles of microRNAs in maintaining tissue identity" ppsx
... 4 Identification of thetargets of eachmiRNAiscrucialforunderstandingthebiological function of miRNAs.Accumulatingempiricalevidencehasrevealedtheimportance of the5-terminalsegment of miRNAswith6-8nucleotidesinlength,called“seed”region, formiRNAfunction[26-29].Forexample,systematicalsinglenucleotidemutation studiesdemonstratedthatbase-pairing of miRNAst...
Ngày tải lên: 14/08/2014, 16:20
Báo cáo Y học: Growth inhibition of mammalian cells by eosinophil cationic protein pptx
... of Bioscience and Biotechnology, Faculty of Engineering, Graduate School of Natural Science and Technology, Okayama University, Japan; 2 Department of Biology, Faculty of Sciences, University ... vitro and in vivo [1,2]. It is classi®ed as a member of the ribonuclease (RNase) A supergene family because of homology of both nucleotide and amino-acid sequences. The homol...
Ngày tải lên: 17/03/2014, 17:20
Báo cáo y học: "Strong inhibition of TNF-α production and inhibition of IL-8 and COX-2 mRNA expression in monocyte-derived macrophages by RWJ 67657, a p38 mitogen-activated protein kinase (MAPK) inhibitor" ppt
... described by Plesner and co-workers [18], and compared MDMs from healthy controls and RA patients. Strong inhibition of mRNA expression and production of TNF-α by RWJ 67657 was found, as well as inhibition ... under control of the p38 MAPK route. Inhibition of the p38 MAPK route may inhibit production not only of TNF-α, but also of other inflammatory mediators...
Ngày tải lên: 09/08/2014, 01:23
Báo cáo y học: " Functional inhibition of NF-κB signal transduction in αvβ3 integrin expressing endothelial cells by using RGD-PEG-modified adenovirus with a mutant IκB gene" ppsx
... pharmacological effects of dnIκB transgene expression in HUVECs by analysis of mRNA levels of typical cell adhesion molecules, cytokines and some other angiogenesis-related genes in HUVECs upon TNF-α ... They affect the endothelial cells per se by inducing the expression of a com- plex array of genes, thereby changing the endothelial activa- tion status and the balance b...
Ngày tải lên: 09/08/2014, 07:20
Báo cáo y học: "Effective detection of rare variants in pooled DNA samples using Cross-pool tailcurve analysis" ppsx
... For all samples validated by Sanger sequencing, homozygous wildtypes are indicated by “-“, heterozygotes are indicated by a “+”, and homozygous mutants are indicated by a “++”. Additional ... study, and Dr. Manuel Rivas of the Massachusetts Institute of Technology and the University of Oxford with assistance in running Syzygy. This work was supported in part by a...
Ngày tải lên: 09/08/2014, 23:20
Báo cáo y học: "Early Inhibition of NF-κB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol)" pot
... sig- nificant efficacy and contribute to the observed in vivo effects. We recently elucidated the cellular effects of δ- (3,4-dihydroxy-phenyl)-γ-valerolactone and δ-(3-meth- oxy-4-hydroxy-phenyl)-γ-valerolactone ... acids and their glyco- sides [1]. About 65–75 % of the Pycnogenol extract are procyanidins that consist of catechin and epicatechin sub- units of varying chain le...
Ngày tải lên: 11/08/2014, 08:21
Báo cáo y học: "Product inhibition of secreted phospholipase A2 may explain lysophosphatidylcholines'''' unexpected therapeutic properties" pot
... composition and LCAT activity in nephrotic and analbuminemic rats. Kidney Int 1994, 46:97-104. 58. Kim YL, Im YJ, Ha NC, Im DS: Albumin inhibits cytotoxic activity of lysophosphatidylcholine by direct ... suggested by the ex vivo and in vitro experiments. Conclusion: The results may explain the efficacy of lysoPC therapy during periods of elevated inflammatory activity and f...
Ngày tải lên: 11/08/2014, 08:22