Báo cáo y học: " Highly pathogenic avian influenza A virus H5N1 NS1 protein induces caspase-dependent apoptosis in human alveolar basal epithelial cells" docx

... RESEA R C H Open Access Highly pathogenic avian influenza A virus H5N1 NS1 protein induces caspase-dependent apoptosis in human alveolar basal epithelial cells Chuanfu Zhang 1,2† , Yutao Yang 1,4† , ... S, Barclay W: Variation in the ability of human influenza A viruses to induce and inhibit the IFN-beta pathway. Virology 2006, 347:52-64. 29. Kurokawa...

Ngày tải lên: 12/08/2014, 04:20

... is highly conserved in all human influenza A strains. It is therefore an attractive target for preparation of a universal influenza A va ccine. In contrast to hemagglutinin and neuraminidase, ... date. Currently available vaccines induce antibodies against seasonal and closely related antigenic viral strains, but do not protect against antibody-escape var- iants of seasonal...

Ngày tải lên: 12/08/2014, 02:20

... [1]. A study of molecular analysis of HAV isolates in Albania has shown that the unique genotype present in Albania is genotype IA [13]. In another study in Albania, only gen- otype I A was characterized ... performed in the last decade in Greece has com- pared clinical and environmental HAV strains [10]. TheaimofthepresentstudywastocorrelateHAV isolates from clinical an d env...

Ngày tải lên: 12/08/2014, 01:21

... caused both damage and activation of airway epithelial cells. Damage to epithelial cells may facilitate the passage of allergens over the mucosal membrane, whereas an increased release of cytokines ... Dr. Martin D. Chapman (Indoor Bio- technologies Ltd, Cardiff, UK). Total protease (using casein as a substrate), elastase (using N-succinyl-alanyl- alanyl-prolyl-leucine p-nitro-anilide a...

Ngày tải lên: 13/08/2014, 13:22

... stained with a rabbit anti -NS1 polyclonal antibody and a mouse anti-NPM monoclonal antibody, revealed with a secondary FITC-labelled anti-rabbit antibody and a secondary RhodamineX-labelled anti-mouse ... with the human influenza A/ Udorn/72(H3N2) strain (desig- nated Udorn), the human laboratory adapted influenza A/ PR/8/34(H1N1) strain (designated PR8), the avian infl...

Ngày tải lên: 12/08/2014, 04:20

... microscopically. The viability was determined using a cell viability assay for the nasal and throat swabs as well as for the nasal turbinates (Cell Titer Aqueous One Reagent, Promega). The lungs were analyzed ... preparation, VY: immunological analysis, SG: clinical pathology analysis, DN: virus preparation, CBJ: participated in design of study, review of findings and manuscript prepara...

Ngày tải lên: 12/08/2014, 04:20

... drugs are available with antiviral activity against influenza viruses: the M2 inhibitors (amantadine and rimantadine), and the neuraminidase inhibitors (oseltamivir and zanamivir). Some currently circulating ... antibody-mediated virus neutralization activity. All operations with H5N1 virus were performed in a bio-safety level 3 (BSL-3) laboratory. Antiserum An inactivated influe...

Ngày tải lên: 12/08/2014, 16:20

... 2008, 82:4965-4973. 23. Sagara Y, Inoue Y, Shiraki H, Jinno A, Hoshino H, Maeda Y: Identifi- cation and mapping of functional domains on human T-cell lymphotropic virus type 1 envelope proteins by using syn- thetic ... Boublik Y, Battini JL, Sitbon M: Human T-cell leukemia virus type 1 envelope-mediated syncytium forma- tion can be activated in resistant Mammalian cell lines by...

Ngày tải lên: 13/08/2014, 05:21

... statistical data indica- ting the quality of the 40 models and the average energy- minimized structure. The polypeptide chain of the human/ rat CRH analogue seems to fold to an almost linear tertiary structure ... are also observed in Leu14–Val18 and Aib15–Leu19. All of the above data imply that the His13–Leu19 backbone structure is probably a conformational average bearing features of...

Ngày tải lên: 17/03/2014, 10:20

... ––––– Sampling Sites: 1. Karasuma Pen., 2. Kita-Yamada, 3. Yabase Kihan Is., 4. Ohashi Marina, 5. Wani Fishing Port, 6. Aoyagi Beach, 7. Shirahige Beach, 8. Shin-Asahi Windmill Village, 9. Lake Yogo ... AGATCT DraI TTTAAA EcoRV GATATC NdeI CATATG MssI GTTTAAAC Sau3AI GATC SspI ACTAGT SwaI ATTTAAAT XbaI TCTAGA Figure 9 Light (upper) and fluorescence (lower) images of Chlorella variabilis. A:...

Ngày tải lên: 12/08/2014, 01:21