... phase of insulinsecretion. A 30 -week, double-blind, placebo-controlled study (100) was performed in 733 subjects (aged 55 ±10 yr, BMI 33 .6 ± 5.7 kg/m(2), HbA1c8.5 ± 1.0%; means ± SD) all of ... atriple-isotope approach (intravenous [ 3- H (3) ]glucose and [(14)C]bicarbonate, and oral [6, 6-( 2)H(2)]glucose), and indirect calorimetry to assess splanchnic and peripheral glucose disposal, direct and ... over-the-counter medications and other supplements.NUTRITIONAL MANAGEMENT OF OVERWEIGHT AND OBESE PATIENTSThe prevalence of overweight and obesity is becoming epidemic. More than two thirds of...