Báo cáo y học: "Inhibition of core gene of HCV 3a genotype using synthetic and vector derived siRNAs" pot
Báo cáo y học: "Inhibition of core gene of HCV 3a genotype using synthetic and vector derived siRNAs" pot
... silen- cingoftheHCV-3aCoregenemaybeoneofthe important therapeutic opportunities against HCV- 3a genotype. Results Efficient siRNAs targeting HCV- 3a Core gene screening siRNA directed against HCV are ... function of E1 and at least 12 amino acids from C-terminus of E1 genes are required fo r E2 function, influencing the proper glycosy- lation of E1 and E2 gene. Effect...
Ngày tải lên: 12/08/2014, 02:20
Báo cáo y học: " Inhibition or knock out of Inducible nitric oxide synthase result in resistance to bleomycin-induced lung injury" potx
... Inhibitory effects of the dietary anti- oxidants butylated hydroxyanisole and butylated hydroxy- toluene on bronchioloalveolar cell proliferation during the bleomycin-induced pulmonary fibrosing ... enzymes, and cytokines that further amplify the inflammatory response by their effects on macrophages and lym- phocytes [71]. Furthermore, we found that the tissue dam- age induced by bleo...
Ngày tải lên: 12/08/2014, 18:21
Báo cáo y học: "The Mammalian Phenotype Ontology as a tool for annotating, analyzing and comparing phenotypic information" potx
... viewed by clicking on the term to expand the view of that portion of the ontology. The number of genotypes and annotations following the term 'lethality-embryonic/perinatal' is a hypertext ... display: lethality/embryonic-perinatal embryonic lethality o generalized developmental arrest after E9.5 o no embryos survived beyond day E11 embryogenesis neural patterning was n...
Ngày tải lên: 14/08/2014, 14:21
Tài liệu Báo cáo Y học: Inhibition of the MEK/ERK signaling pathway by the novel antimetastatic agent NAMI-A down regulates c-myc gene expression and endothelial cell proliferation ppt
... completely inhibited PMA-induced ERK1/2 activation and activity and totally counteracted phorbol ester-primed c-myc gene expression heavily suggests that the inhibitory effect of NAMI-A on c-myc gene ... directed against human sequences for c-myc and GAPDH and PCR conditions were as previously described [20]. Analysis of c- myc gene transcription by nuclear runoff assay To p...
Ngày tải lên: 21/02/2014, 01:21
Báo cáo y học: " Inhibition of HIV-1 gene expression by Ciclopirox and Deferiprone, drugs that prevent hypusination of eukaryotic initiation factor 5A" potx
... modification of a lysine residue catalyzed by deoxyhypusine synthase and deoxyhypusine hydroxylase (DOHH). DOHH activity is inhibited by two clinically used drugs, the topical fungicide ciclopirox and ... catalyzed by DHS, of an aminobutyl moiety (blue) from spermidine onto the side chain of eIF5A lysine-50, yielding deoxyhypusine (Dhp); and its subsequent hydroxylation, catalyze...
Ngày tải lên: 12/08/2014, 23:22
Báo cáo y học: " Intragenic transcriptional cis-activation of the human immunodeficiency virus 1 does not result in allele-specific inhibition of the endogenous gene" pdf
... light both of HIV-1 pathogenesis and of the potential use of lentiviral vectors for gene therapy applica- tions. Results Generation and characterization of a cell line carrying a stably integrated ... obtained by limiting dilutions and colonies were vis- ually scored for low basal level of ECFP expression in the cytoplasm and to be highly inducible by GST-Tat by fluo- res...
Ngày tải lên: 13/08/2014, 05:21
Báo cáo y học: " Inhibition of PP2A by LIS1 increases HIV-1 gene expression" pps
... assayed in the presence of LIS1 and/ or Tat. Lane 1, 1 μg of Tat. Lane 2, 0.2 μg of LIS1. Lane 3, 0.4 μg of LIS1. Lane 4, 0.5 μg of Tat and 0.2 μg of LIS1. Lane 5, 0.5 μg of Tat and 0.4 μg of ... we analyzed the effect of LIS1 on the phos- phorylase phosphatase activity of PP2A. Glycogen phosphorylase-a, a general substrate of PP2A and PP1 phosphatases was prepar...
Ngày tải lên: 13/08/2014, 09:20
Báo cáo y học: " A Novel Variable Number of Tandem Repeat of the Natriuretic Peptide Precursor B gene’s 5’-Flanking Region is Associated with Essential Hypertension among Japanese Females"
... age, 51.2 ± 10.8 years). None of the NT subjects had a family history of hypertension; all had an SBP less than 130 mmHg and a DBP less than 85 mmHg. A family history of hypertension was defined ... [9]. The aim of the present study was to identify mu- tations or polymorphisms in the 5’-flanking region of the NPPB gene and to assess the relationship between variants of...
Ngày tải lên: 26/10/2012, 10:04
Tài liệu Báo cáo Y học: Inhibition of nuclear pre-mRNA splicing by antibiotics in vitro pot
... inhibitory effect of erythromycin and Cl-tetracycline were not allevi- ated by Mg 2+ (Fig. 3). Kinetic analyses using increasing concentrations of erythromycin, Cl-tetracycline and streptomycin up ... ger splicing inhibition by Cl-tetracycline may be explained by the a dditional s ize and hydrophobicity introduced by the substitution, as is often the case in ribozyme inhibition by...
Ngày tải lên: 21/02/2014, 15:20
Báo cáo Y học: Inhibition of hyaluronan synthesis in Streptococcus equi FM100 by 4-methylumbelliferone doc
... level of the has operon containing the hyaluronan synthase gene or the protein level of hyaluronan synthase. Solubilization of the enzyme from membranes of MU-treated cells and addition of the ... method of Laemmli [32]. Assay of cell-free HA synthesis Cell-free HA synthesis was performed by a modification of the method reported by Nakamura et al. [18]. Analysis of the tr...
Ngày tải lên: 08/03/2014, 09:20