báo cáo khoa học:" The role of apoptosis in early embryonic development of the adenohypophysis in rats" ppsx

... purposes) Head & Face Medicine Open Access Research The role of apoptosis in early embryonic development of the adenohypophysis in rats Jens Weingärtner 1 , Kristina Lotz 2 , Andreas Faltermeier 3 , ... of epithelial cells at the basal cones of the adenohypophysis begins even before differentiation of the adenohypophyseal cells and their contact with...

Ngày tải lên: 12/08/2014, 01:22

... or without hematoxylin staining. In hypoxia experiments, 3T3-L1 cells were maintained in a hypoxia chamber (Invivo 400; Ruskinn Inc., Cincinnati, OH, USA) constantly maintained at 1% O 2 . Culture medium ... lgÆmL )1 insulin, 1 lm dexamethasone, and 0.5 mm IDM). Cells were then maintained in DMEM con- taining 10% fetal bovine serum and 1 lgÆmL )1 insulin. The medium was replaced every...

Ngày tải lên: 18/02/2014, 08:20

... thus blocking protein synthesis and leading cells to death. The current model proposed for the mechanism of antitumour action of BS-RNase is based on the ability of the protein to resist the neutralizing ... plateau. These data indicate that the cell sulfhydryls responsible for the exchange with the protein disulfides are located in the plasma membrane. Furthermore, t...

Ngày tải lên: 20/02/2014, 11:20

... molecule comprising Ôresidues in the protruding domain consisting of the type VI b-turn and the first part of b-strand 3Õ (i.e. the b-hairpin loop and part of the adjoining b-sheet) and Ôresidues in the loop ... peptide K in which the sequence of the b-strands was maintained but the amino acids from loop 3 had been replaced by multiple Ser and Gly residues. Ther...

Ngày tải lên: 20/02/2014, 11:20

... dependence of the pH-activity curve of API The pH-activity profiles depending on NaCl concentration were determined as part of the investigation into the shielding from solvent of the electrostatic interaction between ... position. In the struc- tural deviation, the solvent ASA of the side-chain of His210 increased with the decrease in size of the side-cha...

Ngày tải lên: 21/02/2014, 03:20

... mammalian cells [9], the SCC reaction is the rate-determining step in progesterone synthesis in yeast. The yeast SCC system offers the possibility of increasing or decreasing the availability of the endogenous ... hydrolysis, resulting in an increase in intracellular sterol trafficking. It is unclear, then, whether the corresponding increase in pregnenolone pro- duc...

Ngày tải lên: 08/03/2014, 08:20

... showed that the C-terminal muta- tion had clearly affected the trinuclear site geometry. The results in this study clearly confirm the critical role of the last amino acids in the C-terminus of MaL. Abbreviations 2,6-DMP, ... preventing binding of oxygen. We analyzed the azide inhibition and determined the inhibition constants for sodium azide, in order to see th...

Ngày tải lên: 16/03/2014, 00:20

... formation of MRN foci [19–21]. The Mre11-binding domain of human Nbs1 has been localized to amino acids 682–693 in the COOH- terminal region of the protein. Deletion of this region of Nbs1 results in ... damage, thereby promoting ATM-dependent signaling [23]. Domains similar to the ATM-binding domain of Nbs1 are also found in ATRIP and Ku80 and are required for the...

Ngày tải lên: 16/03/2014, 13:20

... This kinetic analysis provided new insight into the role of the linker region. In addition, we fur- ther analyzed the functional role of the linker region based on the crystal structures of a ... exclude the effects of interacting proteins but can also be used to perform kinetic analy- ses of the native and linker-cleaved P-gp. In the present study, we invest...

Ngày tải lên: 29/03/2014, 23:20

... situated in the E-domain of the fibrin molecule, the complementary site ‘c’ is suggested to be situated in the D-domain. We have tried to model the intermolecular binding between the D-domain of one ... situated in the bC-domain in a ‘knob’–‘hole’ type of interaction [7,9]. The remain- ing part of site ‘C’ (Bb19–46) probably remains bound to the fibrin D-domain...

Ngày tải lên: 30/03/2014, 03:20