... RJ,Wouters EF: Determinants of health-related quality of life in patients with chronic obstructive pulmonary disease. Thorax 1996, 51:39-43.7. Wijnhoven HA, Kriegsman DM, Hesselink AE, Penninx BW, de ... re gardless of severity stage of COPD, but theTable 2 Health-related quality of life, psychological status, and limitations in activities of daily living of 337 COPDpatients, according to ATS/ERS ... a disease- specific, health-related quality of life questionnaire consisting of 50 items with 76 weightedresponses that cover 3 domains: Symptoms, Activity, and Impact. The “Symptoms” domain...