Báo cáo y học: " Identification of NCAM that interacts with the PHE-CoV spike protein" pdf
Báo cáo y học: " Identification of NCAM that interacts with the PHE-CoV spike protein" pdf
... coimmunoprecipitation assay to show that only the NCAM was a binding partner of spike protein. We found that a soluble form of anti -NCAM antibody blocked association of the PHE-CoV with N2a cells. Furthermore, ... Co-immunoprecipitation analysis showed that the NCAM was a binding partner of spike protein. In addition, FACS analysis demonstratedthatasoluble fo...
Ngày tải lên: 12/08/2014, 01:22
Báo cáo y học: "Identification of motifs that function in the splicing of non-canonical introns" doc
... factor other than U2AF65 binds the weak- ened PY tracts. Recent work has shown that PUF60 plays a role in splicing by interacting with the PY tract [29]. Our observation that many of the weak PY tracts ... and recruit the spliceosome to the pre-mRNA: the 5' splice site (5'ss, AG/GURAGU), the branchpoint sequence (CURAY), the polypyrimidine (PY) tract (a run...
Ngày tải lên: 14/08/2014, 20:22
Báo cáo y học: "Identification of a SmD3 epitope with a single symmetrical dimethylation of an arginine residue as a specific target of a subpopulation of anti-Sm antibodies" ppsx
... shown). The absence of inhibition can be explained by the variety of different anti-Sm antibody sub- populations and by the variety of corresponding epitopes. Recently, two polyclonal antibodies (SYM10, ... Germany 2 Professor of Medicine, Faculty of Medicine, University of Calgary, Calgary, Canada 3 Vice Director of Autoimmune Diagnostics, Laboratory of Prof. Seelig and...
Ngày tải lên: 09/08/2014, 06:22
Báo cáo y học: "Identification of HLA-DRPheβ47 as the susceptibility marker of hypersensitivity to beryllium in individuals lacking the berylliosis-associated supratypic marker HLA-DPGluβ69" pot
... from the crystal structure, when Phe47 in pocket 7 is substituted for by Tyr47 in the HLA- DR1 and HLA-DR4 molecules, the hydrogen of the Tyr47 hydroxyl is engaged in a hydrogen bound network with the ... stimulation [4-6]. The observation that beryllium disease affects only 1 to 16% of Be-exposed individuals led to the hypothesis that genetic susceptibility may play a...
Ngày tải lên: 12/08/2014, 18:22
Báo cáo y học: "Identification of host proteins associated with HIV-1 preintegration complexes isolated from infected CD4+ cells" potx
... on the catalytic activity of PIC makes it pos- sible to identify physiologically relevant viral-host protein interactions. The integration activity of the isolated complex was confirmed by real-time ... speculate that such factors might play a role in the assembly of PICs and assist the formati on of proviral DNA similar to that of BAF or LEDGF/p75 andfulfilltherolesno...
Ngày tải lên: 13/08/2014, 01:20
Báo cáo y học: "Identification of signaling components required for the prediction of cytokine release in RAW 264.7 macrophages" pdf
... participation of pathways not associated with measurements, we repeated PCR analysis on the part of the cytokine responses that was not fitted by the measured activated signaling pathways (that is, ... minimizing the effect on the homeostasis of other cytokines. The results of the present study demonstrate the power of using heterogeneous cellular data to qualit...
Ngày tải lên: 14/08/2014, 16:21
Báo cáo Y học: Selection of effective antisense oligodeoxynucleotides with a green fluorescent protein-based assay Discovery of selective and potent inhibitors of glutathione S-transferase Mu expression doc
... Determination of the concentration/activity profile of the AS-ODNs To compare the potency and specificity of some of the effective AS-ODNs, COS-7 cells were transfected with different concentrations of AS-1, ... moiety is not affected, whereas the formation of the GSTM1-1 is. This would explain the higher isoform specificity of AS-5 and AS-10 in the EGFP assay, co...
Ngày tải lên: 31/03/2014, 15:20
Báo cáo y học: "Treatment of active lupus nephritis with the novel immunosuppressant 15-deoxyspergualin: an open-label dose escalation study" pps
... compare the efficacy of DSG with established drugs such as MMF, which will answer the question of the true efficacy of this new drug in therapy of LN. Finally, due to its special mode of action, DSG ... suppression of WBC, neutrophils, hemoglobin, or platelets; withdrawal of consent by the patient; decision by the physician that discontinuation was in the best in...
Ngày tải lên: 12/08/2014, 15:22
Báo cáo y học: "Identification of a human peripheral blood monocyte subset that differentiates into osteoclasts" doc
... resorptive therapy, especially for RA. Competing interests The authors declare that they have no competing interests. Authors' contributions YK participated in the design of the study, carried ... produced by osteoclasts, were measured by ELISA. The concentrations of both enzymes were significantly higher in the culture supernatant of CD16 - monocytes than in that o...
Ngày tải lên: 09/08/2014, 08:22
Báo cáo y học: " Identification of functional modules that correlate with phenotypic difference: the influence of network topology" potx
... interpre- tation of expression data, the pathways reported in PWEA give insights into the nature of the different types of cancer that were examined. One of the potential problems with the method pre- sented ... inputs: the expression profiles of two p henotypes, a list of gene sets, and their topology. Inthisstudy,thegenesetsaretakenfromtheKEGG database [64] as o...
Ngày tải lên: 09/08/2014, 20:21