Báo cáo y học: "A role for the histone deacetylase HDAC4 in the life-cycle of HIV-1-based vectors" ppsx

... is involved in the life-cycle of HIV-1- based vectors. Our finding also supports the hypothesis that cellular DSB repai r proteins are invo lved in PIR. At the same time, these proteins clearly ... required for efficient integration or PIR. On the other hand, some reduce the efficiency of integration. Finally, some are involved in integration site selection. We have st...

Ngày tải lên: 12/08/2014, 01:21

Ngày tải lên: 13/08/2014, 01:20

... articular cartilage is maintained by the cartilage cells, chondrocytes. Changes in chondrocytes, leading to the inability of these cells to maintain the homeostasis of articular cartilage, can ... collagen [15].  is cytokine causes destruction of cartilage by increasing enzyme activity while decreasing the synthesis of enzyme inhibi- tors [16]. IL-1 can stimulate chondr...

Ngày tải lên: 12/08/2014, 11:22

... levels of MCP-1 were closely related to the effectiveness of corticos- teroid therapy. Given the assumption that MCP-1 and CCR2 are important players in the pathophysiology of ILD in children, the ... variety of cells, including monocytes/macrophages, lymphocytes and airway epithelial cells [4-6]. MCP-1 stimulates colla- gen synthesis and production of the pro-fibrotic...

Ngày tải lên: 12/08/2014, 18:22

... mortality rate compared with controls, but the difference was not statistically significant (27% versus 43%). The originality of this study lies in the ‘early antibiotic treatment’ arm, in which the ... before, and similar findings were reported by Cinar and colleagues [4]. But in a study by Schwarz and colleagues [5], there was no difference between prophylactic and early the...

Ngày tải lên: 13/08/2014, 11:23

... critical in the regulation of p53. Intriguingly, in the case of Numb it seems unclear whether it is the interaction with MDM2 or the interaction with p53 that is key to protecting p53 from ubiquitination ... stage of binding that is critical for ubiquitination of p53, and it is possible, therefore, that Numb inhibits this second binding step without perturbing the init...

Ngày tải lên: 14/08/2014, 08:21

... signs of arthritis in the tarsal joints were monitored daily in all of the animals. This assessment was performed visually with a scale for swelling (0 to 3) and for erythema (0 to 3) of the hindpaws ... and the distal 10 cm of colon of each Figure 1 Kallikrein–kinin system (KKS)Kallikrein–kinin system (KKS). The KKS is initiated by factor XIIa (FXIIa) or prolylcar...

Ngày tải lên: 09/08/2014, 06:22

... is predominantly expressed in the endothelium of lymphatic vessels. Neuropilin-1, a receptor for semaphorins in the nervous system, is also a receptor for the heparin-binding isoforms of VEGF ... and hydrostatic pulmonary edema may be the dilution caused from the alveolar flooding rather than the degree of lung injury [29]. In the early stage of lung injury dif...

Ngày tải lên: 12/08/2014, 16:20

... preference of the reverse transcriptase enzyme for the Cy3 label and (ii) prolonged exposure to air and light of the dyes increasing the chance of oxidation and / or bleaching. The main contributing ... living resources - the cell factory'. The work of RB, HK, and CdH was supported by SENTER, Ministry of Economic Affairs, in the form of a BTS project....

Ngày tải lên: 14/08/2014, 14:21

... cannot fit into the horseshoe cavity of the inhibitor, whereas a monomeric form of the enzyme can, and is fully inhibited by CRI. Indeed, monomeric RNases lacking cytotoxic activity, such as bovine ... the dimeric structure of the enzyme is essential for its display of cytotoxic activity [3]. This conclusion was based on the lack of cytotoxic activity in a monomeric d...

Ngày tải lên: 20/02/2014, 11:20