Báo cáo y học: "HIV-1 is budded from CD4+ T lymphocytes independently of exosomes" pot

... into endosomes but to an external compartment [24,25]. To the contrary, the findings in CD4+ T lymphocytes are quite inconsistent and uncertain. Some studies suggest that HIV-1 is budded from T cell plasma ... between HIV-1 production and exosome biogenesis. Importantly, we took advan- tage of the newly established protocol to unequivocally show that HIV-1 was produced from...

Ngày tải lên: 12/08/2014, 01:21

... the study. GA wrote the first draft of the manuscript. IR supervised the study and contributed in data discussions and correcting the drafts. Furthermore, IR conceived the study, contributed in the ... The intensity of bands was quantified using image J software (Version 1.41, National Institutes of Health, Bethesda, MD, USA). Statistical analysis Data were presented as means ± SEM. Sta...

Ngày tải lên: 11/08/2014, 03:20

... the study. GA wrote the first draft of the manuscript. IR supervised the study and contributed in data discussions and correcting the drafts. Furthermore, IR conceived the study, contributed in the ... The intensity of bands was quantified using image J software (Version 1.41, National Institutes of Health, Bethesda, MD, USA). Statistical analysis Data were presented as means ± SEM. Sta...

Ngày tải lên: 11/08/2014, 06:22

... target CD4+ T cells is strongly affected by the interplay of these proteins. From the viral point of view, this interplay might give an advantage to HIV-1 replication. One possibility is that MDM2 ... affected the transcriptional activity of the HIV-1 LTR. Because it is well known that MDM2 regulates p53 levels by modulating its protein stability, we next examined the protei...

Ngày tải lên: 13/08/2014, 05:21

... with correctly annotated start codon positions. The most remarkable feature noted in the analysis of 5' UTRs of the bursal cDNAs is a very high GC content (67%). This supports the observation ... manually annotated with respect to their likely translation start codon and deposited both at The Bursal Transcript Database website [18] and in the public databases. The lengths of the...

Ngày tải lên: 14/08/2014, 14:21

... independent risk factor that contributes to morbidity and mortality [4]. If hyperglycaemia is an independent risk factor, then tight glucose control (TGC) may have beneficial effects on morbidity and ... lowers the number of reinfarctions in patients with type 2 diabetes following AMI. In that study, only one out of five patients was treated with coronary artery bypass grafting or prima...

Ngày tải lên: 12/08/2014, 23:24

... HIV-1-infected patients, confirming the upregulation of cofilin activity in resting CD4 T cells of HIV-1-infected patients. Given the great extent of cofilin activation and the fact that a majority of ... dephosphorylation with the prolonged treatment. These data suggest that persistent stimulation with HIV will likely have a lasting impact on the cofilin activity. We also repeated...

Ngày tải lên: 13/08/2014, 05:21

... cytokines prevents the expansion of lym- phocytes, including that of NK cells which function to reject foreign grafts. Intravenous administration of human hematopoietic stem cells together with ... admin- istration of human cytokines leads to a better engraftment rate. A recent breakthrough of even more extensive engraftment without exogenous cytokine administration has been achieve...

Ngày tải lên: 13/08/2014, 09:20

... dataset car- ries with it the possibility of a seriously misleading artifact. To estimate a true phylogenetic relationship, it is necessary to give close attention to the data analysis and to ... grants from the Ministry of Educa- tion, Culture, Sports, Science and Technology of Japan (to NO). This study was also supported in part by grants from Japanese Society for the Promo- tio...

Ngày tải lên: 14/08/2014, 08:20

... rate- limiting step in this approach is that the depth of the cut in the tibial plateau from TKR provides small specimens that did not always permit quantification of the subchondral trabecular structure. ... [11,25,27], the present study provides a comparison of the architecture in BML-affected area with that in other areas within the same tibial plateau. Results of the latter co...

Ngày tải lên: 09/08/2014, 01:22