Báo cáo y học: "Amino acid substitutions in the E2 glycoprotein of Sindbis-like virus XJ-160 confer the ability to undergo heparan sulfate-dependent infection of mouse embryonic fibroblasts" docx

... al.: Amino acid substitutions in the E2 glycoprotein of Sindbis-like virus XJ-160 confer the ability to undergo heparan sulfate-dependent infection of mouse embryonic fibroblasts.Virology Journal ... 145-150 amino acid in the E2 glycoprotein of Sindbis virus in the interaction with cellular heparan sulfate (HS) and in the infection of mouse embryonic fibro-blasts (MEF) cells. In this study, we ... 7:225http://www.virologyj.com/content/7/1/225Page 6 of 6SHOR T REPOR T Open AccessAmino acid substitutions in the E2 glycoprotein of Sindbis-like virus XJ-160 confer the ability to undergo heparan sulfate-dependent...

Báo cáo y học: "Amino acid racemization reveals differential protein turnover in osteoarthritic articular and meniscal cartilages" docx

... occurred in the hyaluronan-binding domain of the A1D1 fraction of proteoglycan [20]. Different age-adjustedproportions of the D amino acids may also vary from oneanother as a result of hot spots ... combination of catabolism and anabolismcould lead to the replacement of D amino acids for L aminoacids, resulting in a reduction of the rate of D/D+L amino acid accumulation. Thus, a study of ... tissues and amino acids.These data further underscored the benefit and utility of including a range of age-matched non-metabolizing controls in any study of the racemization of metabolizing tissue.Materials...

Báo cáo y học: "Uric acid is a strong independent predictor of renal dysfunction in patients with rheumatoid arthritis" docx

... dysfunction may be another link. The role of UA as a mediator of endothelial dysfunction by nitric oxide(NO) inactivation has recently emerged [57,58]. The xanthineoxidase system is one of the main producers ... healthyrats in which mild hyperuricaemia, without crystal deposition,was induced with the use of the uricase inhibitor oxonic acid. This resulted in the development of interstitial renal injury ... significantacceleration of the rate of loss of kidney function [42]. The above studies highlight the role of UA as an independentpredictor of renal dysfunction in the general population. The present study provides...

Báo cáo y học: " Amino acid residues that are important for Hyal2 function as a receptor for jaagsiekte sheep retrovirus" potx

... of mouse Hyal2 is due to the combined action of multiple amino acid changes acting in concert.Interestingly, the mutation R301G increased the receptoractivity of human Hyal2 by 65%. A glycine ... Hyal2 contribute to the low activity of mouse Hyal2. Constructs mhmm and mmhm show thatinsertion of the second domain of human Hyal2 canrestore most of the activity of mouse Hyal2, while inser-tion ... of the changes To identify the individual mouse amino acid changes thataccount for the decreased activity of mouse Hyal2, wemade human Hyal2 mutants containing single and dou-ble mouse amino...

Báo cáo y học: "Amino acid size, charge, hydropathy indices and matrices for protein structure analysis" docx

... protein would fold up spontaneously intoa conformation that minimizes the total free energy of the system.None of the protein structure predicting methods performsatisfactorily, which is very ... similarity to the pattern obtained by SCHM.This might indicate that no one matrix is completely inde-pendent and distant from the natural frequency of aminoacids in the proteins, which is of course ... eachother on the basis of a given physicochemical property.Hydrophobe compatibility matrix and indexHydropathy (hydrophobicity vs. hydrophilicity or lipopho-bicity vs. lipophilicity) is usually...

Báo cáo y học: "Psychological pain treatment in fibromyalgia syndrome: efficacy of operant behavioural and cognitive behavioural treatments" pptx

... time-contingent intake and reduction of medication, increase of bodily activity, reduction of interference of pain with activities,reduction of pain behaviours, and training in assertive pain-incompatible ... 2 = always). The total value of pain behaviours was calculated by summing the absolutefrequencies of the individual pain behaviours observed during the task. The inter-rater reliability was good ... counterbalanced in order to control for time of year and time of entry into the clinical trial.Figure 1 provides an overview of the patient flow in the studybased on the CONSORT guidelines [23].All...

Báo cáo y học: "Inhaled nitric oxide in persistent pulmonary hypertension of the newborn refractory to high-frequency ventilatio" ppsx

... subse-quently delivered to the neonate via the inspiratory limb of the ventilator circuit. The resulting concentration of the inhaled NO and NO2was verified in- line by using an elec-trochemical ... therapy.Inhalation of NO significantly decreased OI (P<0.0001)and improved the a/A ratio (P<0.0001) within the first 2h of INO therapy in 61.1% of the responders, and the remaining responded ... (P<0.0001) within the first 2h of NO therapy in 61.1% of the responders. However, the OI and the a/A oxygen ratio remained almost the samethroughout the treatment in the non-responders and the non-survivors.Conclusion:...

Báo cáo y học: " 2008 Nobel prize in Medicine for discoverers of HIV" ppt

... honoured only thosewho contributed to the discovery of HIV rather than HPVas well the picture may have been different. Instead theychose to reward the two scientists most responsible for the first ... characteristic of the early stage of acquiredimmune deficiency. They detected activity of the retroviralenzyme reverse transcriptase, a direct sign of retrovirusreplication. They also observed retroviral ... isolation of the virus. These two indeed deserve ourcongratulations. It would be churlish however not to acknowledge that the work of others, notably the Gallolab – but also other scientists working...

Báo cáo y học: "Vasopressin improves survival in a porcine model of abdominal vascular inj" ppt

... treatmenteither into a covered bucket or into the central venous line. The infusion rate of fluids was set in all groups to 2 ml/kg at the beginning of the experimental therapy. A three-way stopcockdetermined ... designed the study protocol, conducted the laboratorywork and wrote the manuscript. HGW helped to design the study protocol and was involved in laboratory work. ACK wasinvolved in laboratory work ... designed the study pro-tocol and helped to interpret the data. VW designed the studyprotocol, supervised the laboratory work and was involved in writing the manuscript. All authors read the final...

Báo cáo y học: "Hepatic oxidative stress in an animal model of sleep apnoea: effects of different duration of exposure" potx

... whichappear to be increased in individuals with OSA, is due to the conversion of xanthine dehydrogenase (type D)into its oxidase (type O) form in hypoxia, followed by the activation of the oxidase ... in the homog enate, was monito red spectrophotometricallyat 480 nm. The amount of enzyme that inhibited 50% of epinephrine auto-oxidation was defined as 1 U of SODactivity. The analysis of ... Hepatology 2011, 10:1http://www.comparative-hepatology.com/content/10/1/1Page 4 of 7 The auto-oxidation rate of epinephrine, which is pro-gressively inhibited b y increasing amounts of SOD in the...

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