Báo cáo y học: "Amino acid substitutions in the E2 glycoprotein of Sindbis-like virus XJ-160 confer the ability to undergo heparan sulfate-dependent infection of mouse embryonic fibroblasts" docx

... al.: Amino acid substitutions in the E2 glycoprotein of Sindbis-like virus XJ-160 confer the ability to undergo heparan sulfate-dependent infection of mouse embryonic fibroblasts. Virology Journal ... 145-150 amino acid in the E2 glycoprotein of Sindbis virus in the interaction with cellular heparan sulfate (HS) and in the inf...

Ngày tải lên: 12/08/2014, 01:21

... occurred in the hyaluronan-binding domain of the A1D1 fraction of proteoglycan [20]. Different age-adjusted proportions of the D amino acids may also vary from one another as a result of hot spots ... combination of catabolism and anabolism could lead to the replacement of D amino acids for L amino acids, resulting in a reduction of the rate of D/D+L amino...

Ngày tải lên: 09/08/2014, 13:22

... dysfunction may be another link. The role of UA as a mediator of endothelial dysfunction by nitric oxide (NO) inactivation has recently emerged [57,58]. The xanthine oxidase system is one of the main producers ... healthy rats in which mild hyperuricaemia, without crystal deposition, was induced with the use of the uricase inhibitor oxonic acid. This resulted in the...

Ngày tải lên: 09/08/2014, 14:22

... of mouse Hyal2 is due to the combined action of multiple amino acid changes acting in concert. Interestingly, the mutation R301G increased the receptor activity of human Hyal2 by 65%. A glycine ... Hyal2 contribute to the low activity of mouse Hyal2. Constructs mhmm and mmhm show that insertion of the second domain of human Hyal2 can restore most of the a...

Ngày tải lên: 13/08/2014, 09:21

... protein would fold up spontaneously into a conformation that minimizes the total free energy of the system. None of the protein structure predicting methods perform satisfactorily, which is very ... similarity to the pattern obtained by SCHM. This might indicate that no one matrix is completely inde- pendent and distant from the natural frequency of amino acids in the pr...

Ngày tải lên: 13/08/2014, 23:20

... time- contingent intake and reduction of medication, increase of bodily activity, reduction of interference of pain with activities, reduction of pain behaviours, and training in assertive pain- incompatible ... 2 = always). The total value of pain behaviours was calculated by summing the absolute frequencies of the individual pain behaviours observed during the task....

Ngày tải lên: 09/08/2014, 08:22

... subse- quently delivered to the neonate via the inspiratory limb of the ventilator circuit. The resulting concentration of the inhaled NO and NO 2 was verified in- line by using an elec- trochemical ... therapy. Inhalation of NO significantly decreased OI (P<0.0001) and improved the a/A ratio (P<0.0001) within the first 2h of INO therapy in 61.1% of the re...

Ngày tải lên: 12/08/2014, 18:20

... honoured only those who contributed to the discovery of HIV rather than HPV as well the picture may have been different. Instead they chose to reward the two scientists most responsible for the first ... characteristic of the early stage of acquired immune deficiency. They detected activity of the retroviral enzyme reverse transcriptase, a direct sign of retrovirus r...

Ngày tải lên: 13/08/2014, 05:21

... treatment either into a covered bucket or into the central venous line. The infusion rate of fluids was set in all groups to 2 ml/kg at the beginning of the experimental therapy. A three-way stopcock determined ... designed the study protocol, conducted the laboratory work and wrote the manuscript. HGW helped to design the study protocol and was involved in laborat...

Ngày tải lên: 13/08/2014, 08:20

... which appear to be increased in individuals with OSA, is due to the conversion of xanthine dehydrogenase (type D) into its oxidase (type O) form in hypoxia, followed by the activation of the oxidase ... in the homog enate, was monito red spectrophotometrically at 480 nm. The amount of enzyme that inhibited 50% of epinephrine auto-oxidation was defined as 1 U of S...

Ngày tải lên: 13/08/2014, 13:20