Human Developmental Toxicants - Part 11 ppt

... 352 Human Developmental Toxicants 76543210 20 10 0 Frequency H-bond acceptor Human developmental toxicants - H-bond acceptor 76543210 20 10 0 Positive Negative Human growth retardation - H-bond ... 350 Human Developmental Toxicants 1614121086420 10 5 0 Positive Negative Frequency Polarity Human functional deficit - polarity 3020100 10 5 0 Frequency Human...

Ngày tải lên: 12/08/2014, 00:21

... Propranolol Chemical name: 1-[ (1-Methylethyl)amino ]-3 -( 1-naphthalenyloxy-2-propanol) CAS #: 52 5-6 6-6 SMILES: c12c(OCC(CNC(C)C)O)cccc1cccc2 INTRODUCTION Propranolol is a β -blocking drug with ... 6 Mechlorethamine Chemical name: 2-Chloro- N -( 2-chloroethyl )- N -methylethanamine Alternate names: Nitrogen mustard, chlormethine CAS #: 5 1-7 5-2...

Ngày tải lên: 12/08/2014, 00:21

... Francis Group, LLC 11 3 Cyclophosphamide Chemical name: N , N - Bis (2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine-2-oxide CAS #: 605 5-1 9-2 SMILES: P1(N(CCCl)CCCl)(NCCCO1)=O ... 105 Chemistry 107 References 108 Chapter 22 Ethylene Oxide 111 Introduction 111 Developmental Toxicology 111 Animals 111 Humans 111 7229_book.fm Page xxii F...

Ngày tải lên: 12/08/2014, 00:21

... Group, LLC 49 11 Vitamin A Chemical name: 3,7-Dimethyl- 9 -( 2,6,6-trimethyl-1-cyclohexen-1-yl )-2 ,4,6,8-nonatetraen-1-ol Alternate names: Oleovitamin A, retinol CAS #: 6 8-2 6-8 SMILES: C1(C(CCCC=1C)(C)C)C=CC(=CC=CC(=CCO)C)C ... Group, LLC 63 13 Danazol Chemical name: 17 α -Ethynyl-17 β -hydroxy-4-androsteno[2, 3- d ]isoxazole CAS #: 1723 0-8 8...

Ngày tải lên: 12/08/2014, 00:21

... LLC 93 19 Misoprostol Chemical name: (11 α ,13E )-1 1,16-Dihydroxy-16-methyl-9-oxoprost-13-en-1-oic acid methyl ester CAS #: 5912 2-4 6-2 SMILES: C1(C(C(CC1O)=O)CCCCCCC(OC)=O)C=CCC(CCCC)(C)O ... Francis Group, LLC 87 18 Captopril Chemical name: 1-[ 2 S -3 -Mercapto-2-methyl-1-oxopropyl ]- L -proline CAS #: 6257 1-8 6-2 SMILES: N1(C(CCC1)C(O)=O)C(...

Ngày tải lên: 12/08/2014, 00:21

... 0 -2 -Deoxy- 2-( methylamino- α - L -glucopyranosyl-1(1 → 2 )- 0 -5 -deoxy- 3- C -formyl- α - L -lyxofuranosyl-(1 → 4 )- N,N ′ - bis (aminoiminomethyl )- ... 115 23 Tetracycline Chemical name: [4 S -( 4 α ,4a α ,5a α ,6 β ,12a α ) ]-4 -( Dimethylamino )-1 ,4,4a,5,5a, 6-1 1,12a- octahydr...

Ngày tải lên: 12/08/2014, 00:21

... Chemical name: ( all - E )-9 -( 4-Methoxy-2,3,6-trimethylphenyl )-3 ,7-dimethyl-2,4,6, 8- nonatetraenoic acid ethyl ester Alternate name: Ro-1 0-9 359 CAS #: 5435 0-4 8-0 SMILES: c1(c(c(c(cc1C)OC)C)C)C=CC(=CC=CC(=CC(OCC)=O)C)C ... Norethindrone Chemical name: (17 α )-1 7-Hydroxy-19-norpregn-4-en-20-yn-3-one Alternate names: 19-Norethisterone, norpregnenin...

Ngày tải lên: 12/08/2014, 00:21

... Valsartan Chemical name: N -( 1-Oxopentyl )- N -[ [2 ′ -( 1 H -tetrazol-5-yl)[1,1 ′ -biphenyl ]-4 -yl]methyl ]- L -valine CAS #: 13786 2-5 3-4 SMILES: n1nc([nH]n1)c2ccccc2c3ccc(cc3)CN(C(C(C)C)C(O)=O)C(CCCC)=O ... Acitretin Chemical name: (all-E )-9 -( 4-Methoxy-2,3,6-trimethylphenyl )-3 ,7-dimethyl- 2,4,6,8-nonatetraenoic acid Alternate n...

Ngày tải lên: 12/08/2014, 00:21

... & Francis Group, LLC 324 Human Developmental Toxicants TABLE 1 Developmental Toxicity Reported with 50 Human Developmental Toxicants Chapter and Agent Developmental Toxicity Reported Growth ... CHEMICAL CHARACTERIZATION OF HUMAN DEVELOPMENTAL TOXICANTS Both physicochemical and topological parameters were calculated for all of the 50 human devel- opmental t...

Ngày tải lên: 12/08/2014, 00:21

... 338 house design, 240 human benefit, 3 human cognition, expanding, 85 Human Cognome Project, x, 85, 130, 282 Human Genome Project, 38, 86, 258, 282, 367 human performance, 171 human performance, ... Technologies for Improving Human Performance (pre-publication on-line version) 389 Jill Banfield University of California at Berkeley Department of Earth and Planetary Sciences and D...

Ngày tải lên: 05/08/2014, 21:20