Human Developmental Toxicants - Part 10 potx

... & Francis Group, LLC 324 Human Developmental Toxicants TABLE 1 Developmental Toxicity Reported with 50 Human Developmental Toxicants Chapter and Agent Developmental Toxicity Reported Growth ... CHEMICAL CHARACTERIZATION OF HUMAN DEVELOPMENTAL TOXICANTS Both physicochemical and topological parameters were calculated for all of the 50 human devel- opmental t...

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... 99 Developmental Toxicology 99 Animals 99 Humans 100 Chemistry 101 References 102 Chapter 21 Methimazole 105 Introduction 105 Developmental Toxicology 105 Animals 105 Humans 105 Chemistry 107 References ... Cyclophosphamide Chemical name: N , N - Bis (2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine-2-oxide CAS #: 605 5-1 9-2 SMILES:...

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... Propranolol Chemical name: 1-[ (1-Methylethyl)amino ]-3 -( 1-naphthalenyloxy-2-propanol) CAS #: 52 5-6 6-6 SMILES: c12c(OCC(CNC(C)C)O)cccc1cccc2 INTRODUCTION Propranolol is a β -blocking drug with ... 6 Mechlorethamine Chemical name: 2-Chloro- N -( 2-chloroethyl )- N -methylethanamine Alternate names: Nitrogen mustard, chlormethine CAS #: 5 1-7 5-2...

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... Vitamin A Chemical name: 3,7-Dimethyl- 9 -( 2,6,6-trimethyl-1-cyclohexen-1-yl )-2 ,4,6,8-nonatetraen-1-ol Alternate names: Oleovitamin A, retinol CAS #: 6 8-2 6-8 SMILES: C1(C(CCCC=1C)(C)C)C=CC(=CC=CC(=CCO)C)C ... Group, LLC 63 13 Danazol Chemical name: 17 α -Ethynyl-17 β -hydroxy-4-androsteno[2, 3- d ]isoxazole CAS #: 1723 0-8 8-5 SMILES: C12C(C3C(...

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... 93 19 Misoprostol Chemical name: (11 α ,13E )-1 1,16-Dihydroxy-16-methyl-9-oxoprost-13-en-1-oic acid methyl ester CAS #: 5912 2-4 6-2 SMILES: C1(C(C(CC1O)=O)CCCCCCC(OC)=O)C=CCC(CCCC)(C)O ... Francis Group, LLC 87 18 Captopril Chemical name: 1-[ 2 S -3 -Mercapto-2-methyl-1-oxopropyl ]- L -proline CAS #: 6257 1-8 6-2 SMILES: N1(C(CCC1)C(O)=O)C(C(CS)...

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... 0 -2 -Deoxy- 2-( methylamino- α - L -glucopyranosyl-1(1 → 2 )- 0 -5 -deoxy- 3- C -formyl- α - L -lyxofuranosyl-(1 → 4 )- N,N ′ - bis (aminoiminomethyl )- ... Chemical name: [4 S -( 4 α ,4a α ,5a α ,6 β ,12a α ) ]-4 -( Dimethylamino )-1 ,4,4a,5,5a, 6-1 1,12a- octahydro-3,6 ,10, 12,12a-pentahydr...

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... Chemical name: ( all - E )-9 -( 4-Methoxy-2,3,6-trimethylphenyl )-3 ,7-dimethyl-2,4,6, 8- nonatetraenoic acid ethyl ester Alternate name: Ro-1 0-9 359 CAS #: 5435 0-4 8-0 SMILES: c1(c(c(c(cc1C)OC)C)C)C=CC(=CC=CC(=CC(OCC)=O)C)C ... Norethindrone Chemical name: (17 α )-1 7-Hydroxy-19-norpregn-4-en-20-yn-3-one Alternate names: 19-Norethisterone, norpregnenin...

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... Acitretin Chemical name: (all-E )-9 -( 4-Methoxy-2,3,6-trimethylphenyl )-3 ,7-dimethyl- 2,4,6,8-nonatetraenoic acid Alternate names: Etretin, Ro-1 0-1 670 CAS #: 5507 9-8 3-9 SMILES: c1(c(c(c(cc1C)OC)C)C)C=CC(=CC=CC(=CC(O)=O)C)C ... Valsartan Chemical name: N -( 1-Oxopentyl )- N -[ [2 ′ -( 1 H -tetrazol-5-yl)[1,1 ′ -biphenyl ]-4 -yl]methyl ]...

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... 352 Human Developmental Toxicants 76543 210 20 10 0 Frequency H-bond acceptor Human developmental toxicants - H-bond acceptor 76543 210 20 10 0 Positive Negative Human growth retardation - H-bond ... 350 Human Developmental Toxicants 16141 2108 6420 10 5 0 Positive Negative Frequency Polarity Human functional deficit - polarity 302 0100 10 5 0 Fr...

Ngày tải lên: 12/08/2014, 00:21