Human Developmental Toxicants - Part 5 doc
Human Developmental Toxicants - Part 5 doc
...
0
-2 -Deoxy- 2-( methylamino-
α
-
L
-glucopyranosyl-1(1
→
2 )-
0
-5 -deoxy-
3-
C
-formyl-
α
-
L
-lyxofuranosyl-(1
→
4 )-
N,N
′
-
bis
(aminoiminomethyl )-
...
1 15
23
Tetracycline
Chemical name: [4
S
-( 4
α
,4a
α
,5a
α
,6
β
,12a
α
) ]-4 -( Dimethylamino )-1 ,4,4a ,5, 5a, 6-1 1,12a-
octahy...
Human Developmental Toxicants - Part 1 docx
...
Chapter 43
Etretinate
25
5
Introduction 255
Developmental Toxicology 255
Animals 255
Humans
256
Chemistry
257
References 258
Chapter 44
Toluene 261
Introduction 261
Developmental Toxicology ...
Cyclophosphamide
Chemical name:
N
,
N
-
Bis
(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine-2-oxide
CAS #: 6 05 5- 1 9-2
SMILES: P1(N(CCCl)CC...
DEVELOPMENTAL NEUROBIOLOGY - PART 5 docx
... that blood mercury in Thimerosal-exposed
2-month-olds ranged from less than 3. 75 to 20 .55 parts per billion;
in 6-month-olds, all values were lower than 7 .50 parts per billion
(Pichichero et ... N-methyl-d-aspartate receptors in
O-2A glial precursor cells: A critical role in regulating polysialic acid
neural cell adhesion molecule expression and cell migration, J. Cell
Biol. 1 35: 156 5–...
Human Developmental Toxicants - Part 2 pptx
... –0. 959
HLB 21 .54 0
Solubility parameter 36. 455 J
(0 .5)
/cm
(1 .5)
Dispersion 23.2 85 J
(0 .5)
/cm
(1 .5)
Polarity 12.664 J
(0 .5)
/cm
(1 .5)
Hydrogen bonding 25. 028 J
(0 .5)
...
Propranolol
Chemical name: 1-[ (1-Methylethyl)amino ]-3 -( 1-naphthalenyloxy-2-propanol)
CAS #: 52 5- 6 6-6
SMILES: c12c(OCC(CNC(C)C)O)cccc1cccc2
INTRODUCTION...
Human Developmental Toxicants - Part 3 pdf
...
Vitamin A
Chemical name: 3,7-Dimethyl-
9
-( 2,6,6-trimethyl-1-cyclohexen-1-yl )-2 ,4,6,8-nonatetraen-1-ol
Alternate names: Oleovitamin A, retinol
CAS #: 6 8-2 6-8
SMILES: C1(C(CCCC=1C)(C)C)C=CC(=CC=CC(=CCO)C)C
... 0.762
xv0 9.706
xv1 5. 729
xv2 4.1 25
xvp3 3.018
xvp4 2.211
xvp5 1 .55 8
xvp6 0.860
xvp7 0 .50 7
xvp8 0.300
xvp9 0.167
xvp10 0.090
k0 18.380
k1 13.0 05
k2 5. 55...
Human Developmental Toxicants - Part 4 pdf
...
93
19
Misoprostol
Chemical name: (11
α
,13E )-1 1,16-Dihydroxy-16-methyl-9-oxoprost-13-en-1-oic
acid methyl ester
CAS #: 59 12 2-4 6-2
SMILES: C1(C(C(CC1O)=O)CCCCCCC(OC)=O)C=CCC(CCCC)(C)O ... Francis Group, LLC
87
18
Captopril
Chemical name: 1-[ 2
S
-3 -Mercapto-2-methyl-1-oxopropyl ]-
L
-proline
CAS #: 6 257 1-8 6-2
SMILES: N1(C(CCC1)C(O)=O)C(C(...
Human Developmental Toxicants - Part 8 pdf
...
255
43
Etretinate
Chemical name: (
all
-
E
)-9 -( 4-Methoxy-2,3,6-trimethylphenyl )-3 ,7-dimethyl-2,4,6, 8-
nonatetraenoic acid ethyl ester
Alternate name: Ro-1 0-9 359
CAS #: 54 35 0-4 8-0
SMILES: ... Value
x0 15. 5 35
x1 10.483
x2 10.263
xp3 9.772
xp4 8.030
xp5 6 .55 4
xp6 5. 055
xp7 3. 952
xp8 2.978
xp9 2.222
xp10 1.436
xv0 13.476
xv1 8.918
xv2...
Human Developmental Toxicants - Part 9 ppsx
...
LogP 5. 126
HLB 0. 354
Solubility parameter 25. 502 J
(0 .5)
/cm
(1 .5)
Dispersion 21.260 J
(0 .5)
/cm
(1 .5)
Polarity 3.3 25 J
(0 .5)
/cm
(1 .5)
Hydrogen bonding 13.686 J
(0 .5)
... 2.292
xp9 1 .57 2
xp10 1.074
xv0 18. 654
xv1 10.867
xv2 8.1 45
xvp3 5. 430
xvp4 3.793
xvp5 2.386
xvp6 1.384
xvp7 0.836
xvp8 0 .51 5
xvp9 0.281
xvp10 0.166
k0 46. 359
k1 2...
Human Developmental Toxicants - Part 10 potx
... 52 .19 A
3
Density 0.822 g/cm
3
Surface area 80.00 A
2
LogP –0.2 35
HLB 5. 0 75
Solubility parameter 25. 0 95 J
(0 .5)
/cm
(1 .5)
Dispersion 15. 032 J
(0 .5)
/cm
(1 .5)
Polarity 8. 351 J
(0 .5)
/cm
(1 .5)
Hydrogen ... 124.9 28.0 58 1.7
Molecular volume 240.1 112.2 28.1 50 2.8
Density 1.1127 0.1922 0.8133 1 .53 19
Surface area 301.7 136.7 45. 5 640.4
LogP 1. 054 3 .54 6 –12. 158...
Human Developmental Toxicants - Part 11 ppt
... Toxicants
7 654 3210
15
10
5
0
xp8
Frequency
Human functional deficit - xp8
Positive
Negative
5. 04 .54 .03 .53 .02 .52 .01 .51 .00 .50 .0
20
10
0
xp9
Frequency
Human developmental toxicants - xp9
Human growth retardation - xp9
5. 04 .54 .03 .53 .02 .52 .01 .51 .00 .50 .0
20
10
0
xp9
Frequency
Positive
Negative
... Histograms
355
4 .54 .03 .53 .02 .52 .01 .51...
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