Human Developmental Toxicants - Part 4 pdf
Human Developmental Toxicants - Part 4 pdf
...
93
19
Misoprostol
Chemical name: (11
α
,13E )-1 1,16-Dihydroxy-16-methyl-9-oxoprost-13-en-1-oic
acid methyl ester
CAS #: 5912 2 -4 6-2
SMILES: C1(C(C(CC1O)=O)CCCCCCC(OC)=O)C=CCC(CCCC)(C)O ... Francis Group, LLC
87
18
Captopril
Chemical name: 1-[ 2
S
-3 -Mercapto-2-methyl-1-oxopropyl ]-
L
-proline
CAS #: 6257 1-8 6-2
SMILES: N1(C(CCC1)C(O)=O)C(C(CS)...
Human Developmental Toxicants - Part 3 pdf
... Group, LLC
49
11
Vitamin A
Chemical name: 3,7-Dimethyl-
9
-( 2,6,6-trimethyl-1-cyclohexen-1-yl )-2 ,4, 6,8-nonatetraen-1-ol
Alternate names: Oleovitamin A, retinol
CAS #: 6 8-2 6-8
SMILES: ... Value
x0 15.880
x1 9.8 64
x2 8.972
xp3 6.317
xp4 4. 772
xp5 2.751
xp6 2.218
xp7 0.953
xp8 0.638
xp9 0.361
xp10 0.316
xv0 14. 240
xv1 7.875
xv2 6.665
xvp3 4. 187
xvp4 2. 844...
Human Developmental Toxicants - Part 8 pdf
...
255
43
Etretinate
Chemical name: (
all
-
E
)-9 - ( 4- Methoxy-2,3,6-trimethylphenyl )-3 ,7-dimethyl-2 ,4, 6, 8-
nonatetraenoic acid ethyl ester
Alternate name: Ro-1 0-9 359
CAS #: 543 5 0 -4 8-0
SMILES: ... Group, LLC
237
41
Norethindrone
Chemical name: (17
α
)-1 7-Hydroxy-19-norpregn -4 - en-20-yn-3-one
Alternate names: 19-Norethisterone, nor...
Human Developmental Toxicants - Part 1 docx
... 237
Humans 238
Chemistry 239
References 240
Chapter 42
Phenytoin 243
Introduction 243
Developmental Toxicology 243
Animals 243
Humans 244
Malformation 244
Growth Retardation 248
Death 248
Functional ... Group, LLC
17
4
Methotrexate
Chemical name:
N
-[ 4- [ [(2 , 4- Diamino-6-pteridinyl)methyl]methylamino]benzoyl ]-
L
-glutamic acid
Alternate name: Amethop...
Human Developmental Toxicants - Part 2 pptx
...
Lancet
341 : 8856
.
xp10 0.3 24
xv0 14. 441
xv1 7.867
xv2 6.761
xvp3 4. 125
xvp4 2.875
xvp5 1 .49 9
xvp6 1.101
xvp7 0. 346
xvp8 0.199
xvp9 0.100
xvp10 0.082
k0 28.931
k1 20. 046
k2 9.333
k3 7 .42 2
ka1 ... 2007 by Taylor & Francis Group, LLC
41
9
Propranolol
Chemical name: 1-[ (1-Methylethyl)amino ]-3 -( 1-naphthalenyloxy-2-propanol)
CAS #: 52 5-6 6-6
SMIL...
Human Developmental Toxicants - Part 5 doc
...
0
-2 -Deoxy- 2-( methylamino-
α
-
L
-glucopyranosyl-1(1
→
2 )-
0
-5 -deoxy-
3-
C
-formyl-
α
-
L
-lyxofuranosyl-(1
→
4 )-
N,N
′
-
bis
(aminoiminomethyl )-
...
Chemical name: [4
S
-( 4
α
,4a
α
,5a
α
,6
β
,12a
α
) ] -4 -( Dimethylamino )-1 ,4, 4a,5,5a, 6-1 1,12a-
octahydro-3,6,10,12,12a-pentahyd...
Human Developmental Toxicants - Part 9 ppsx
... Group, LLC
279
47
Valsartan
Chemical name:
N
-( 1-Oxopentyl )-
N
-[ [2
′
-( 1
H
-tetrazol-5-yl)[1,1
′
-biphenyl ] -4 -yl]methyl ]-
L
-valine
CAS #: 13786 2-5 3 -4
SMILES: n1nc([nH]n1)c2ccccc2c3ccc(cc3)CN(C(C(C)C)C(O)=O)C(CCCC)=O
... LLC
273
46
Acitretin
Chemical name: (all-E )-9 - ( 4- Methoxy-2,3,6-trimethylphenyl )-3 ,7-dimeth...
Human Developmental Toxicants - Part 10 potx
... parameter 24. 245 4. 649 14. 493 36 .45 5
Dispersion 20 .46 6 3.091 14. 493 27.189
Polarity 5.973 3.780 0.000 15. 748
Hydrogen bonding 10.173 5.305 0.000 25.626
H bond acceptor 1. 040 1.1 24 0.000 6. 640
H bond ... X
43 . Etretinate X X
44 . Toluene X X X X
45 . Ethisterone X
46 . Acitretin X X
47 . Valsartan X X X
48 . Diethylstilbestrol X X X
49 . Pseudoephedrine X
50. Ethanol X...
Human Developmental Toxicants - Part 11 ppt
...
352
Human Developmental Toxicants
76 543 210
20
10
0
Frequency
H-bond acceptor
Human developmental toxicants - H-bond acceptor
76 543 210
20
10
0
Positive
Negative
Human growth retardation - H-bond ...
377
1816 141 2108 642 0
15
10
5
0
xp4
Frequency
Human malformation - xp4
Positive
Negative
1816 141 2108 642 0
15
10
5
0
xp4
Frequency
Human functional deficit...
Converging Technologies for Improving Human Performance Episode 2 Part 4 pdf
... Group and Societal Outcomes
252
than a top-of-the-line supercomputer of only two decades ago. One giga-op (one billion operations per
second) single-board computers are now on the market. There ... result, intelligent machines are
Converging Technologies for Improving Human Performance (pre-publication on-line version)
249
E
NGINEERING OF
M
IND TO
E
NHANCE
H
UMAN
P
RODUCTIVITY
James S...
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