... example by producing certain setsof cytokines that influence the quality and extent of theinflammatory process [6]. Cytokines, in turn, can elicit theproduction of tissue-degrading enzymes, a ... (AIA) in synovial membrane (SM), inguinal lymph node(LN), and spleen using competitive RT-PCR and sandwichELISA. In the SM, early elevations of IL-1β and IL-6 mRNA (by 6hours; 450- and 200-fold, ... IL-4 and IL-5 (2.5- and 4-fold, respectively, by day 3). No significantelevations of the corresponding proteins in this tissue wereobserved, except for IL-1β (by day 6) and IL-10 (by day 1). In...