... 110:651-658.85. Kamei D, Yamakawa K, Takegoshi Y, Mikami-Nakanishi M,Nakatani Y, Oh-Ishi S, Yasui H, Azuma Y, Hirasawa N, Ohuchi K,et al.: Reduced pain hypersensitivity and inflammation in micelacking ... a multicellularinflammatory process, including infiltration of lymphocytes and granulocytes into the articular cartilage, proliferation of synovial fibroblasts and macrophages and neovascularization of ... synthase-2 did not affect inflammation, althoughcartilage degradation was reduced substantially [82]. On the other hand, cyclooxygenase (COX)2 is a key enzyme involvedin the metabolism of arachidonic...