Báo cáo y học: "Role of innate signalling pathways in the immunogenicity of alphaviral replicon-based vaccines" potx

... by these types of vectors is mediated by induction of danger signals and activation of innate signalling pathways due to the replicase activity. To investigate the innate signalling pathways involved, ... yet been investigated in head-to-head comparisons if these are the same for DREP vaccines. In this study we investigated if innate signalling pathways are i...

Ngày tải lên: 11/08/2014, 21:21

... of a variety of inflammatory chemokines and their receptors [5,6]. In vitro studies have suggested that both so-called homeostatic chemokines and inflammatory chemokines, including CC chemokine ... on the available in vivo data, which may provide more insight into the chances that disrupting one single factor of the complicated chemokine network could be clinically effective...

Ngày tải lên: 09/08/2014, 01:23

... processes underlying RP and PAH contribute to the familiar pattern of skin, renal and gastrointestinal pathology. The emergence of effective and conveniently administered therapy for PAH increases the importance ... vasculopathy of SScl may also be modifiable. In the characteristic microangiopathy of SScl, luminal narrowing results from a combination of intimal proliferati...

Ngày tải lên: 09/08/2014, 06:23

... important in the proliferation of RA FLSs in the pathogenesis of RA. Introduction Synovial tissue from healthy individuals consists of a single layer of synovial cells without infiltration of inflammatory ... purposes) Figure 5 Inhibitory effects of neutralizing antibodies to cytokines on the SF-mediated proliferation capacity of RA FLSsInhibitory effects of neutrali...

Ngày tải lên: 09/08/2014, 08:23

... type II synthesis, whereas proteoglycan synthesis was strongly attenuated. In contrast, at the time of maximal aggre- canase activity, the proteoglycan loss was fully reversible. These findings ... points. Proteoglycans in the cartilage were visualized using Alcian blue staining, the same dye used in the S-GAG assay. The control articular car- tilage explants (shown in...

Ngày tải lên: 09/08/2014, 10:23

... quality control program run by the Korean Society of Laboratory Medicine [3]. In 1999 and 2007, reports of antinuclear antibody test using the IT-1 cell line on 208 and 588 systemic lupus erythematosus (SLE) ... passed inspection by the Korea Food and Drug Administration in South Korea. Currently, IT-1 is being used under the name of the autoimmune target (AIT) test and it...

Ngày tải lên: 09/08/2014, 14:21

... systematic study is mandatory to compare the sensitivity and specificity of the AIT test for the detection of anti-Rib-P antibodies and other antibody specificities using a variety of contemporary diagnostic ... assay, and then used these sera to determine the positivity and staining patterns in the AIT test. This method raises concerns because it is generally known that imm...

Ngày tải lên: 09/08/2014, 14:22

... for the first time. The outcomes of this trial are therefore likely t o strongly influence practice guidelines and clinical care in this area. This trial will be limited by its inability to blind ... secondary growth plate of the calcaneus. The calcaneal growth cen- tre or apophysis appears at approximately seven years of age [4] and fuses in girls of age approximately thi...

Ngày tải lên: 10/08/2014, 21:24

... vascular injury [6]. While certain drugs are known to cause spe- cific types of injury, the type of injury in idiosyncratic drug reactions can be of variable morphology. A liver biopsy can be ... idiosyncratic hepatotoxicity. The main treatment of drug-induced liver toxicity is withdrawal of the offending agent. Most patients recover completely; therefore, management involve...

Ngày tải lên: 11/08/2014, 00:23

... stereotyped thinking, and poor attention items of the scale Psychosis SCAP-HQ Bothered much by feeling that others are spying against you or plotting against you, hearing voices that other people ... between them and their family, and the protection they have against being robbed or attacked Satisfaction with social life SCAP-HQ Combines the patient’s feeling about the way they spen...

Ngày tải lên: 11/08/2014, 15:22