Báo cáo y học: " Inhibition of lung serine proteases in mice: a potentially new approach to control influenza infection" doc
Báo cáo y học: " Inhibition of lung serine proteases in mice: a potentially new approach to control influenza infection" doc
... thereby initiate the infection process
[1-4]. The cleavage site of HA0 of most avian and mam-
malian influen za viruses is monobasic and carries a sin-
glearginine,rarelyasinglelysineaminoacid.Cleavage
has ... Switzerland). This
substrate contains an alkaline amino acid (arginine) in
theP1siteupstreamthep-NA group that favors
proteolysis by trypsin like serine proteases at alkalin...
Báo cáo hóa học: " Inhibition of G1P3 expression found in the differential display study on respiratory syncytial virus infection" docx
... mechanisms.
Background
Respiratory syncytial virus (RSV), a leading cause of epi-
demic respiratory tract infection in infants, spreads prima-
rily by contact with contaminated secretions and
replicates in the nasopharyngeal ... WD, Yang H, Kong X, Mohapatra S, Juan-Vergara HS, Heller-
mann G, Behera S, Singam R, Lockey RF, Mohapatra SS: Inhibition of
respiratory syncytial virus i...
Báo cáo Y học: Inhibition of glycosyl-phosphatidylinositol biosynthesis in Plasmodium falciparum by C-2 substituted mannose analogues pot
... nonmannosylated GPtdIns
glucosamine-phosphatidylinositol (GlcN–PtdIns) and glu-
cosamine-acylphosphatidylinositol (GlcN-acyl–PtdIns)
(Fig. 2). These data imply that mannosamine was
incorporated into ... nor
nonmannosylated intermediates accumulated in the pre-
sence of mannosamine. The absence of new mannosamine-
containing GPtdIns and the inhibition of incorporation of
tritiate...
Báo cáo y học: "Inhibition of oncogene-induced inflammatory chemokines using a farnesyltransferase inhibitor" pot
... Aggarwal BB: Protein farnesyltransferase
inhibitor (SCH 66336) abolishes NF-kappaB activation
induced by various carcinogens and inflammatory stimuli
leading to suppression of NF-kappaB-regulated ... [26]
as well as pro-inflammatory cytokines such as Ccl2, Il6,
and Ifn
β
[27] induced by carcinogens and inflammatory
stimuli.
We have shown here that clinically-relevant nanomolar
doses of...
Báo cáo y học: "Importance of lysosomal cysteine proteases in lung disease" ppt
... gelatinases A and B, stromelysin,
and the cathepsins. Extracellular degradation of collagen
can be incomplete, leaving fragments to be phagocytosed
by cells such as fibroblasts, macrophages and ... humans. By activat-
ing granzymes A and B, DPPI might regulate the
lymphocyte-mediated cytotoxicity of virally infected or
malignant cells [45]. Cytotoxic T lymphocytes and natural
killer...
Báo cáo y học: "Inhibition of HIV-1 replication in primary human monocytes by the IκB-αS32/36A repressor of NF-κB" docx
... function as a major HIV-1 reser-
voir in vivo. In addition, monocytes are programmed to
produce a large amount of inflammatory cytokine, includ-
Genome structure and expression of recombinant pNL(AD8)IκB-αS32/3 6A ... levels of transcription factors, includ-
ing NF-κB, which sustain the initial rounds of viral repli-
cation and induce the production of inflammatory
cytoki...
Báo cáo y học: " Inhibition of caspase-1 activation in gram-negative sepsis and experimental endotoxemia" ppsx
... release of pro-inflammatory cytokines by
circulating monocytes and may explain, at least in part,
the failure of most of these trials.
Down-regulation of cytokine production was accom-
panied by ... impaired in their
capacity to produce these pro-inflammatory cytokines in
vitro [3]. This impairment is part of a second hypo-
inflammatory state of the septic cascade also k...
Tài liệu Báo cáo Y học: Inhibition of the MEK/ERK signaling pathway by the novel antimetastatic agent NAMI-A down regulates c-myc gene expression and endothelial cell proliferation ppt
... ERK1/2.
Recent observations indicate that activation of Raf by
PMA may trigger the same signaling pathway as oncogenic
Raf, or Raf activation by Ras in combination with tyrosine
phosphorylation [30]. ... of
different intracellular checkpoint pathways. Among these,
the mitogen-activated protein kinase (MAPK)/extracellular
signal-regulated kinase (ERK) pathway has been proposed
to play...
Tài liệu Báo cáo Y học: Inhibition of nuclear pre-mRNA splicing by antibiotics in vitro pot
... lus ¯anking exons of genomic rabbit DNA was
ampli®ed by PCR techniques. For PCR, the primers b-glb1/
P(5¢-AATCTGGTACCTCACCTGGACAACCTCAAA-
3¢)andb-glb2/M (5¢-AATAAGAATTCGCCAAAAT
GATGAGACAGCA-3¢) ... self-cleavage (tetracycline), of group-I intron self-
splicing (streptomycin) a nd inhibition of RNase P cleavage
by some am inoglycosides. Cl-tetracycline a nd the amino-
cyclitol glyc...
Báo cáo Y học: Inhibition of hyaluronan synthesis in Streptococcus equi FM100 by 4-methylumbelliferone doc
... (Millipore Japan, Tokyo, Japan), and stained with
anti-spHAS antibody according to the method of Towbin
et al.[35]using3,3¢-diaminobenzidine tetrahydrochloride
(Dojindo Laboratories, Kumamoto, Japan) ... 25–1190 of AF023876.
RNA preparations and Northern hybridization
Total RNA was prepared from FM100 cells using a
RNeasy Plant Mini Kit (Qiagen Japan, Tokyo, Japan)
according to the...
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