Particle Toxicology - Chapter 18 ppsx

... was followed by 24-h, 1-week, 1-month, and 3-month recovery periods. Exposure groups • • PBS (vehicle control) Particle- types (1 and 5mg/kg) oR-100 fine-TiO 2 oPigment A-fine-TiO 2 coated with ... fine-sized TiO 2 particle- types [2]. The Pulmonary bioassay bridging study Inhalation studies Carbonyl iron particles α -quartz particles Intratracheal instillation studies PBS sham α -quartz par...

Ngày tải lên: 11/08/2014, 21:21

... 5.4.Itisuseful to grade the response of the lung to particle- induced oxidative stress, with low-leveloxidativestress resultinginanup-regulation of endogenous extra- and intracellular responses,prior to the ... if particle- induced pulmonary inflammatory processesare afunction of the numbers of Particle Toxicology1 04 © 2007 by Taylor & Francis Group, LLC 5.2.4 M ETAL C HELATION P ROT...

Ngày tải lên: 11/08/2014, 21:21

... of the MAPK and NF-kB cascade induces proinflammatoryresponses, including production of IL-4, IL-5, IL-8, IL-10,IL-13,RANTES, MIP- 1 a ,MCP-3, GM-CSF, TNF-a ,ICAM-1, and VCAM-1. At higher levels ... insoluble fraction of diesel exhaust particles, Toxicol. Sci.,91, 218 226, 2006. Particle Toxicology2 56 © 2007 by Taylor & Francis Group, LLC It is evident that inhaled particles and some o...

Ngày tải lên: 11/08/2014, 21:21

... gentleman's son. That my - ' she stopped, and wept outright; upset at the bare notion of relationship with WUTHERING HEIGHTS (ĐỒI GIÓ HÚ) EMILY BRONTE CHAPTER 18 The twelve years, ... scarcely refrain from smiling at this antipathy to the poor fellow; who was a well-made, athletic youth, good-looking in features, and stout and healthy, but attired in garments befit...

Ngày tải lên: 04/07/2014, 03:20

... Security Market Security Market 1995 12 6 3 2 9 4 6 1996 -9 -1 2 -1 8 -1 6 324 256 288 1997 -6 0 -1 5 -4 225 16 60 1998 30 -4 21 -8 441 64 -1 68 1999 18 30 9 26 81 676 234 Totals 45 20 0 0 1,080 1,016 420 Average ... (.17 - .1r f )/.9 = .188 89 - .1111r f r f = [1.35( .188 89 - .1111r f ) - .23]/.35 1.42857r f = .07143 r f = .05 r m = (.17...

Ngày tải lên: 04/07/2014, 10:20

... publicity negative publicity © 2010 South-Western, a part of Cengage Learning. All rights reserved. 18 10 Word-of-Mouth Influence Word-of-Mouth Influence • Word-of-Mouth (WOM) Word-of-Mouth (WOM)  Is both complex ... Edition Marketing-Oriented Public Relations and Word-of-Mouth Management CHAPTER 18 © 2010 South-Western, a part of Cengage Learning. All rights reserved. 18 11 Preve...

Ngày tải lên: 31/07/2014, 17:20

... pyrethroid with the simple com- mon name bioallethrin has the name (RS )-3 -allyl-2-methyl-4-oxocyclo- pent-2-enyl(1R,3R )-2 ,2-dimethyl- 3-( 2-methylprop-1-enyl)cyclopropanecar- boxylate from the International ... analogues of DDT in his efforts to relate toxicity to molecular shapes. DCC (1,1-di-(p-chlorophenyl-2,2-dichlo- rocyclopropane)), is rather toxic. A newer study of structure...

Ngày tải lên: 11/08/2014, 12:21

... Substructure-Based SAR in Toxicology 329 © 2005 by Taylor & Francis Group, LLC ing human cytochrome P4502D6 (cyp2D6). Other toxicants known to inhibit that isozyme include 1,2,3,6-tetrahydro- 1- methyl-4-phenylpyridine ... chlorine atom substituted on the thrid non-hydro- gen atom from the left. 4.0 A! indicates a 2-D 4 Angstrom distance descriptor. In toxicophore no. 18, the second...

Ngày tải lên: 11/08/2014, 17:22

... theseparticles can be seen. Once the particlesimpact on the substrate the moisture envelope aroundthe solid nucleus eva- porates away. Theparticles are thus characterizedbyan“eroded” solid particle ... nanoparticles aggregated in nanostructured nickel oxide particles. (b) Silicon dioxide nanoparticles aggregated in nanostructured silicon dioxide particles. (c) Surface detail of nanostruc- t...

Ngày tải lên: 11/08/2014, 21:21

... Nuclear Factor-k B 128 6.7.1 ROS and RNS Regulation of NuclearFactor-k B 128 6.7.2 Particle- Induced Activation of NF-k B 129 6.7.3 Particle- Induced Activation of AP-1 129 6.8 Particle- Induced Apoptosis ... NO % on NF-k Bactivation in other studies (Umansky et al. 1998; Diaz-Cazorla, Perez-Sala, and Lamas 1999). 6.7.2 P ARTICLE-INDUCED A CTIVATION OF NF-k B Particle- induced activationo...

Ngày tải lên: 11/08/2014, 21:21