Particle Toxicology - Chapter 9 pps

... nuclear factor (NF)-kappaB: Requirement of Ras/mitogen-acti- vated protein kinases in the activation of NF-kappaB by oxidants, Am. J. Respir. Cell Mol. Biol., 20, 94 2, 199 9. 44. Ramage, L. and ... Napier University CONTENTS 9. 1 Particle- Induced Inflammation and Disease 183 9. 2 The Role of EpithelialCells in Driving Particle- Induced Inflammation 185 9. 3 The Effects of Particles on M...

Ngày tải lên: 11/08/2014, 21:21

... radical, super- oxide anion, and singlet oxygen (96 98 ). It also interferes with lipid peroxidation by maintaining the activities of anti- oxidant enzymes at high levels (99 ). The ortho-substituted phenolic, ... mutagenic) car- cinogens, which is the class of agents associated with risk to humans ( 29 33), then one might consider deriving a dozen or more separate SAR models (e.g., TA 100-S9...

Ngày tải lên: 11/08/2014, 17:22

... 199 2;Lynnetal. 199 7), intracellular radical production (Huang,Klein,and Costa 199 4),and intracellular glutathione depletion (Rodriguez et al. 199 1; Herrero et al. 199 3; Li, Zhao, and Chou 199 3), ... Kratzing 197 4; Skoza, Snyder,and Kikkawa 198 3; van der Vliet et al. 199 9), urate (Peden et al. 199 0), reduced glutathione (GSH) (Cantin et al. 198 7; Jenkinson, Black,and Lawrence 198 8)...

Ngày tải lên: 11/08/2014, 21:21

... Newman 199 3; Rusznak,Devalia, and Davies 199 4; D’Amato 199 9; Hajat et al. 199 9; Nicolai 199 9), and recentassociationshavebeenspecificallylinked to proximitytohighways (Brunekreef et al. 199 7; Delfino ... of the MAPK and NF-kB cascade induces proinflammatoryresponses, including production of IL-4, IL-5, IL-8, IL-10,IL-13,RANTES, MIP- 1 a ,MCP-3, GM-CSF, TNF-a ,ICAM-1, and VCAM-1. At higher...

Ngày tải lên: 11/08/2014, 21:21

... Pacing and Electrophysiology, Circulation ,93 , 1043, 199 6. 49. Creason, J., Particulate matter and heart rate variability among elderly retirees: the Baltimore 199 8 PM study, J. Expo. Anal. Environ. ... and hospital admissions for the elderly in Minneapolis-St. Paul, Minne- sota, Arch. Environ. Health, 49, 366, 199 4. 14. Eichelbaum, M., Ingelman-Sundberg, M., and Evans, W. E., Pharmacoge...

Ngày tải lên: 11/08/2014, 21:21

... was followed by 24-h, 1-week, 1-month, and 3-month recovery periods. Exposure groups • • PBS (vehicle control) Particle- types (1 and 5mg/kg) oR-100 fine-TiO 2 oPigment A-fine-TiO 2 coated with ... and10mg/kg), thetoxicity of OTES-coated TiO 2 particles was not significantly different from the hydrophilic R-100 fine-TiO 2 particles. R-100 fine-TiO 2 has amean particle diameter of 300 nm and ....

Ngày tải lên: 11/08/2014, 21:21

... in those three customer departments, who will use the e-commerce system, and also implement the offering of their own services via the e-commence service to their customers. There might well ... in the sense of being organizationally structured as a team – but they must act as a team none-the-less if the project is to be completed within all the constraints. The project manager is respon...

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Ngày tải lên: 02/07/2014, 20:20

... at double-digit rates in the late 198 0s and the very early 199 0s when increases in the consumer price index, a broad measure of the cost of living, were falling. 2 In the mid- 199 0s, healthcare ... wholly wrong, is foreign to him. The win- list, yes-no discussion of politics is not within his purview. He does not recognize the either-or, the all-or-nothing situation as his own. His is...

Ngày tải lên: 02/07/2014, 22:20

... Chemical Week (February 3–10, 199 9), p. 16. REALITY CHECK Chapter 9 Cost Allocation for Joint Products and By-Products 345 Can You Believe It? NEWS NOTEGENERAL BUSINESS E-commerce infomediaries are ... Costing 370 Chapter 9 Cost Allocation for Joint Products and By-Products 3 49 EXHIBIT 9 3 Decision Points in a Joint Production Process Do not produce Do not produce Determine best...

Ngày tải lên: 02/07/2014, 22:21