báo cáo khoa học: " Cutaneous lesions of the nose" pot
báo cáo khoa học: " Cutaneous lesions of the nose" pot
... in the central face [4]. Because of this exposed, highly visible localization, lesions on the skin of the nose are often noticed by patients themselves, typically very early in the course of the ... nose The skin of the nose is a very common location for malig- nant tumors. UV-light exposure is a potent carcinogen of the skin, which results in frequent tumor involv...
Ngày tải lên: 11/08/2014, 20:20
báo cáo khoa học:" Cutaneous lesions of the external ear" pptx
... uniqueness is the high concentration of holocrine ceruminal glands in the skin of the external ear canal. The cerumen may mask existing diseases of the skin in the entrance of the external ear ... avul- sion of the cyst wall. Cysts removed from the back of the ears have the highest recurrence rates (13% and 13.8%) [4]. Regardless of the chosen treatment,...
Ngày tải lên: 12/08/2014, 00:20
báo cáo khoa học: "Hepatoid adenocarcinoma of the gallbladder" pot
... gallblad- der. The gallbladder origin of the hepatoid adenocarci- noma was verified by the presence of foci of conventional adenocarcinoma, the recognition of high- grade dysplasia in the adjacent epithelium ... the HAC was verified by the presence of foci of conventional adenocarcinoma but also by the recognition of high-grade dysplasia in the adjacent epithel...
Ngày tải lên: 09/08/2014, 02:21
Báo cáo khoa học: Constitutive expression of the human peroxiredoxin V gene contributes to protection of the genome from oxidative DNA lesions and to suppression of transcription of noncoding DNA pdf
... in the regulation of these genes. It should be noted that, although the exact positions of the AREs are not con- served between different mammalian species, at least 50% of all AREs in all of these ... 6C). Therefore, knockdown of the PRDX5 gene stimulated transcription of some families of human satellite DNA, which may be caused by direct involvement of PRDX5 in silen...
Ngày tải lên: 30/03/2014, 11:20
Tài liệu Báo cáo khoa học: Crystal structure of the cambialistic superoxide dismutase from Aeropyrum pernix K1 – insights into the enzyme mechanism and stability pdf
... ligand, NE2 of His31, bound to the metal, in the company of a water oxygen, from the apical positions. The manga- nese was only 0.06 A ˚ out of the equatorial plane (Table 3). The angles around the metal ... counted the interactions, we excluded all residues involved in the binding of the metal cofactor. ApeSODs in different forms were superimposed with the least...
Ngày tải lên: 14/02/2014, 22:20
Tài liệu Báo cáo khoa học: Homologous expression of the nrdF gene of Corynebacterium ammoniagenes strain ATCC 6872 generates a manganese-metallocofactor (R2F) and a stable tyrosyl radical (Y•) involved in ribonucleotide reduction ppt
... to the catalytic site of the R1E subunit. As reported in the Results, upon completion of substrate conversion, the radical is then rapidly passed back from the R1E subunit to the tyrosyl of the ... RNR and that of other class 1 RNRs or, instead, is a result of the interaction of the R2F with the inactivated (oxidized) form of the R1E. We consider the first...
Ngày tải lên: 15/02/2014, 01:20
Tài liệu Báo cáo khoa học: Crystal structures of the regulatory subunit of Thr-sensitive aspartate kinase fromThermus thermophilus pdf
... EC 2.7.2.4) is an enzyme that catalyzes the first committed step, the phosphorylation of the c-carboxyl group of aspartate, of the biosynthetic pathway of the aspartic acid group amino acids Lys, Thr, ... and B) sections of the structure are not seen on the map, probably owing to disorder of these regions. The over- all geometry of the model according to the p...
Ngày tải lên: 18/02/2014, 08:20
Tài liệu Báo cáo khoa học: Limited suppression of the interferon-b production by hepatitis C virus serine protease in cultured human hepatocytes pptx
... PH5CH8 cells. First, we confirmed the effect of NS3-4A on the activation of the IFN-b gene promoter by the Cardif exogenously expressed in PH5CH8 cells. The results of the lucif- erase reporter assay ... that the activation of IRF-3 by M-pIC treatment is mediated by the TLR3 ⁄ TRIF signaling pathway. We obtained further evidence by examining the status of the phos...
Ngày tải lên: 18/02/2014, 16:20
Tài liệu Báo cáo khoa học: Kinetic characterization of the first step of the ribozyme-catalyzed trans excision-splicing reaction docx
... between the two steps of the TES reaction The substrate guanosine to be excised (G 1 ) and its 2¢-OH group are required for the second step of TES [48], similar to (if not the same as) the role of the ... slower than the Tetrahymena ribozyme. Therefore, it appears that there is room for improve- ment in terms of the rate of reaction. This would be beneficial not so...
Ngày tải lên: 18/02/2014, 18:20
Tài liệu Báo cáo khoa học: Crystal structure of the catalytic domain of DESC1, a new member of the type II transmembrane serine proteinase family pptx
... Lys224– Tyr228 (the back of the pocket) and the disulfide bridge Cys191–Cys220 (the front of the pocket) (Fig. 4A). The backbones of these segments form a deep hydrophobic pocket with the negatively ... below). The southern boundary of the active site cleft of DESC1 is formed by the 145 autolysis loop. The backbone of this loop differs mark- edly from the othe...
Ngày tải lên: 19/02/2014, 00:20