... prostacyc-lin and carbon monoxide are known intrahepatic vasodi-lating substances, whereas endothelin-1, superoxide (O2-), angiotensin-II, epinephrine and others act as vasocon-stricting agents ... a vasodilator/vasoconstrictor imbalance may be further aggravated by the reducedactivity of superoxide dismutase. Decreased activity allows enhanced superoxide action, which maylead to breakdown ... Hempstead, UK) and with bovine serum albumin as standards. As positive controls were taken: a lysate ofhuman aorta endothelial cells (Transduction Labs, Lex-ington, USA) for eNOS; a homogenate...