báo cáo khoa học: " Psychosocial and contextual correlates of opioid overdose risk among drug users in St Petersburg, Russia" pot

báo cáo khoa học: " Psychosocial and contextual correlates of opioid overdose risk among drug users in St. Petersburg, Russia" pot

... expressed interest in receiving training in overdose prevention and response.Conclusion: Opioid overdose experience is very common among drug users in St. Petersburg, Russia, and interest in receiving ... explored it in detail. In order to gain a clearerunderstanding of the situation, 60 drug users, both in and out of drug treatment in St. Petersburg, wereinterviewed concerning their overdose experience ... The study findings also indicated that St. Petersburg drug users tended to overdose within fouryears of initiating opioid use. This suggests the impor-tance of reaching individuals early in...

Báo cáo khoa học: Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis pot

... 1c-ActinActin, cytoplasmic 1Tubulin b Tubulin aAnkyrin repeatdomain-containing protein 18AAnkyrin repeatdomain-containingprotein 18AHeat-shock protein b1a-Actin-2UnclassiﬁedKeratin, ... phos-phorylation-dependent 14-3-3-binding protein in con-trol conditions. Analysis using the highest-stringencysettings in the scansite algorithm showed Ser39 in vimentin to be the most probable 14-3-3-binding site(Table ... dynamics, RNA binding, DNA binding and chromatin structure, cellular trafﬁcking, and pro-tein folding. Some of them were previously shown tobe associated with 14-3-3 isoforms (indicated in Table...

Báo cáo khoa học: Cloning and functional characterization of Phaeodactylum tricornutum front-end desaturases involved in eicosapentaenoic acid biosynthesis doc

... libraryusing a combination of PCR ampliﬁcation, mass sequencing and library screening as described in the Materials and methods. The ﬁrst clone was 1689 bp and contained anORF of 1434 bp coding for ... PtD5.Protein domainsFigure 2 shows the amino acid sequences of the proteinsencoded by PtD5 and PtD6 (PtD5p and PtD6p, respect-ively). Both proteins contain the three conserved histidineclusters ... forcloning genes encoding fatty acid desaturases involved in eicosapentaenoic acid biosynthesis. Using a combination of PCR, mass sequencing and library screening, the codingsequences of two...

Báo cáo khoa học: "Clinical and pathological assessment of different suture techniques for microvascular anastomosis in rat femoral artery" ppsx

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báo cáo khoa học: " Radiological and pathological findings of a metastatic composite paraganglioma with neuroblastoma in a man: a case report" pptx

... fea-ture in neuroblastoma. Other unfavorable prognosticindicators for neuroblastic tumors include age and stageat diagnosis, histologic subtype, mitotic-karyorrhexisindex, and a variety of other ... the leading prognosticfeature since metastases occur more often from thiscomponent. Accordingly, in our case the metastaseswere of neuroblastoma-type. Both, the neuroendocrine and the ne uronal ... Kantonsspital Winterthur, 8400Winterthur, Switzerland.3Institute of Diagnostic Radiology, UniversityHospital Zurich, 8091 Zurich, Switzerland.Authors’ contributionsTF and SK analyzed the clinical and...

báo cáo khoa học: " Isolation and functional characterization of a cDNA coding a hydroxycinnamoyltransferase involved in phenylpropanoid biosynthesis in Cynara cardunculus L" potx

... choleretic, diuretic and bile-expelling activities [4], (iv) the inhibition of HIVintegrase, a key player in HIV replication and its insertioninto host DNA [14,15], and (v) antibacterial and antifun-gal ... 14,000 g for 5min, and both supernatant and pellet were assayed forHCT activity, and profiled by SDS-PAGE (10% resolvinggel, 5% stacking gel) using Coomassie brilliant blue stain-ing [36]. Negative ... [36].Purification and cloning of globe artichoke HCTReverse transcription from total RNA was achieved usingpoly(dT)primer and M-MuLV RNaseH- RT (Finnzymes,Finland), following the manufacturer's instructions.Incomplete...

Báo cáo khoa học: "Lameness and Claw Lesions of the Norwegian Red Dairy Cattle Housed in Free Stalls in Relation to Environment, Parity and Stage of Lactation" pps

... in tie stalls (Ma-ton 1987, Thysen 1987, Faye & Lescourret1989, Sogstad et al., in press). In tie stalls thelying-, standing-, milking- and feeding area isrestricted to one station. In ... participating clawtrimmers and farmers and also Kerstin Plym-Forshellwho was a main promoter in the planning stage of thestudy. The study was funded by TINE NorwegianDairies BA, GENO Breeding and ... concentrate,silage and pasture in feeding units in the study popu-lation and the whole country (tie stalls and free stalls) in 2002 (SD).VariableHerds in study Herds in Norway(n=57) (n=17...

Tài liệu Báo cáo khoa học: Functional and structural analyses of N-acylsulfonamidelinked dinucleoside inhibitors of RNase A ppt

... resonance studies of the structure and binding sites of enzymes. 8. Inhibitor binding toribonucleases. J Mol Biol 45, 491–511.33 Ui N (1971) Isoelectric points and conformation of proteins. I. ... similarity in theKmvalues is attributable to the uracil moiety binding in the same fashion [38], which could trigger the initialbinding of both substrates. In UpG, the binding of theguanine moiety ... and has numerous interesting homologs [2–4]. In humans, angiogenin (RNase 5) is an inducer of neovascularization, and plays an important role in tumor growth [5]. Eosinophil-derived neurotoxin(RNase...

Tài liệu Báo cáo khoa học: Active and regulatory sites of cytosolic 5¢-nucleotidase doc

... site 2Study of cN-II crystallized in the presence of adeno-sine indicates that this nucleoside binds to this site,even though only the amino acid residues involved in the binding of the purine ... sites 1 and 2 and involved in bind-ing of adenylic nucleotides and BPG.Our results partially conﬁrm the molecular model-ling, suggesting that effector site 1 is the binding sitefor Ap4A and ... site 2 indicated by the crystal structureobtained in the presence of adenosine. In contrast toTable 4. Variation of the protein molecular mass in the presence of speciﬁc effectors as estimated...

Tài liệu Báo cáo khoa học: Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1 docx

... activity of PRTFDC1towards hypoxanthine and guanine is only 0.26% and 0.09%, respectively, of the activity of HPRT, the role of the PRTFDC1 in purine metabolism remainsunclear and it is uncertain ... and hypoxanthine. (B) HPRT and hypoxanthine. (C) PRTFDC1 and guanine. (D) HPRT and guanine.Table 2. Km and Vmaxvalues for Hx and G in the presence of 1 mM PRPP, determined using the DE-81 ... N-terminus and two short ﬂexible loopsleft unmodeled. The 3D structures of HPRTs havebeen divided into a core and a hood domain [14]. Thecore domain of PRTFDC1 contains a six-strandedtwisted...

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