báo cáo khoa học: " Return to Galileo? The Inquisition of the International Narcotic Control Board" ppt

... professionals, now have access to the best tools for the medical tool-belt, even if it contradicts the scripture of the American war on drugs. The real question here is how we will return to the ... Access Commentary Return to Galileo? The Inquisition of the International Narcotic Control Board Dan Small* 1,2 and Ernest Drucker 3,4 Address: 1 Departme...

Ngày tải lên: 11/08/2014, 18:20

... evolves towards the burial of these groups within a globular structure, away from the water mole- cules in the solvent. During the process of folding, as well as in its final fold, the stability of the ... etc.), the pK a difference between heteroatoms is of importance: the smaller this difference, the stronger the hydrogen bond, as the hydrogen atom is equally sh...

Ngày tải lên: 14/02/2014, 18:20

... [10]. The Cys residue was added to the C-terminal end of the 13-amino-acid peptide corresponding to the primary sequence of the Tat protein to provide a sulfhydryl group for further ligation to ... [17,20]. A receptor-mediated mech - anism of cellular i nternalization of the peptide thus appears unlikely. The number of arginine residues within the Tat peptide...

Ngày tải lên: 21/02/2014, 03:20

... mechanisms to control the aggregation states of these substrates and supports our original hypothesis that mammalian cellular factors enable endogenous proteins to be presented to the c-secretase complex ... in elu- cidating the mechanism of inhibitors [7–9], the struc- ture of active c-secretase complexes [10,11], and have aided in the finding of activity-modulating...

Ngày tải lên: 16/03/2014, 23:20

... differen- tial binding of methadone to its variants [9], it is presently not possible to determine whether and to what extent this could influence sensitivity to respiratory depression. At the pharmacodynamic ... the most interesting factors are genetic polymorphisms described for the µ-opioid receptor, in particular the 118A>G single nucleotide polymorphism at exon 1 of...

Ngày tải lên: 13/08/2014, 03:20

... interruption of the geometry of the recognition helix for either Antp or the TTF-1 HD, the anomalous amide exchange pattern and the NOE connectivity data of the C-terminal portion of helix III had to be ... respec- tively. The proximity to one of the intercepts between the theoretical and fitting curves reflects the relative contribution of each component Lor...

Ngày tải lên: 18/02/2014, 16:20

... analyses of the predicted amino acid sequence showed that the C-terminal half of the RepA of the pIT3 plasmid is sequence-similar to the helicases of the phage-encoded superfamily III pro- teins. The ... in pGEMTeasy vector (Promega, Milan, Italy). The nucleotide sequences of both DNA strands of the inserts were verified. The NdeI–XhoI fragments were cloned in...

Ngày tải lên: 18/02/2014, 18:20

... because of the relative lack of protection of the catalytic domain and the junction nucleotides that link it to the other major domain. We attempted to probe the InDG b RNA with Fe 2+ -EDTA in the ... 23S.5DG b pre-RNA, and the binding of a minimum of n Mg 2+ ions leads to formation of the active complex, whereas binding of a minimum of m Mn 2+ ions forms...

Ngày tải lên: 19/02/2014, 07:20

... the origin of the kingdom Plantae among the phyla of the ancestral kingdom Protozo a [45]. Hence, it is reasonable to suppose a common origin of extant APXs in the ancient line of protists. The ... though the C-domains of the catalase–peroxid- ases had lost the ability to bind the prosthetic heme group, the structural elements remained conserved. In additio...

Ngày tải lên: 19/02/2014, 16:20

... Mutations in the tip of the minidomain were found to affect the stop codon specificity of the factor. The results provide new insights into the possible role of the C-domain in the process of translation ... supported by the existence of strong cros- speaks between the signal of the HN of Gly337 in the open conformer and the signal of the water pro...

Ngày tải lên: 06/03/2014, 11:20