báo cáo khoa học: " Innocent parties or devious drug users: the views of primary healthcare practitioners with respect to those who misuse prescription drugs" ppt
báo cáo khoa học: " Innocent parties or devious drug users: the views of primary healthcare practitioners with respect to those who misuse prescription drugs" ppt
... 7:21http://www.harmreductionjournal.com/content/7/1/21Page 7 of 11RESEA R C H Open Access Innocent parties or devious drug users: the views of primary healthcare practitioners with respect to those who misuse prescription drugsRachael Butler*, ... article as: Butler and Sheridan: Innocent parties or devious drug users: the views of primary healthcare practitioners with respect to those who misuse prescription drugs. Harm Reduction Journal ... ieved to acquire prescription medicines fortheir own use or for selling on to the illicit market.They were either viewed as ‘recreational’ drug users who sought prescription drugs for the ‘...
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Tài liệu Báo cáo khoa học: Hypothalamic malonyl-CoA and CPT1c in the treatment of obesity pptx
... ghrelin, as well as other hormones ⁄ cytokines,interact with their cognate receptors on neurons within the CNS that project to higher brain centers and to peripheral tissues to affect energy intake ... is the carboxylation of acetyl-CoA to form malonyl-CoA, catalyzed by ACC – the key reg-ulatory enzyme in the pathway. Malonyl-CoA serves as the basic chain-elongating substrate for the formation of ... environmentalconditions such as the scarcity of food. For higherorganisms, this involves storing energy as fat duringperiods of an abundant food supply to hedge againstperiods of food shortage. Today, humans...
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Tài liệu Báo cáo khoa học: An engineered disulfide bridge mimics the effect of calcium to protect neutral protease against local unfolding docx
... unfolding without the interference of auto-proteolysis, the addition of inhibitors to the enzymeswas examined. Inhibitors such as phosphoramidon or o-phenanthroline are fluorescent and disturb the applied ... the intermediate in the unfolding.Calcium ions are the main contributory factor to enzyme stability The binding of calcium ions seems to be the mainsource of stabilization of the neutral protease ... al. [33] took advantage of autoproteolysis of the HIV protease to monitor local unfolding events byNMR. Obviously, nonlinear chevron plots act as anindicator for the occurrence of the intermediate...
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Tài liệu Báo cáo khoa học: "From HOPE en I''''ESPERANCE On the Role of Computational Neurolinguistics in Cross-Language Studies " pptx
... INHIBITORY and EXCITATORY in its effect. INTERPRETATION is a result of acti- vation of a pragmatic representation of a disambiguated word meaning. It is the in interaction of the results of these ... which forces use of articles in all of the above contexts, as well as on-line production of these morphemes in an attempt to determine in which way these morphemes are related to the words. ... approach to compre- hension of French, will form the basis of the discussion. 4.1 Word Boundaries in On-Line Comprehension of French Because of the parallel activation of all meanings of each...
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Tài liệu Báo cáo khoa học: "Language Resources Factory: case study on the acquisition of Translation Memories" potx
... will help them during the designphase, being able to reuse workflows (or parts of them) and thus avoiding reinveinting the wheel.4 Using the tools to work with NLPAll the aforementioned tools were ... provide the required computational resources the performance will be poor.Following the example of the Bioinformaticsfield where users can benefit of powerful WSPs, the factory is used as a proof of ... need to install in order to design and run experiments isa WS client or a Workflow editor.3 Choosing the tools for the platformDuring the design phase several technologieswere analyzed to study...
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Báo cáo khoa học: Death inducer obliterator protein 1 in the context of DNA regulation Sequence analyses of distant homologues point to a novel functional role docx
... CGBP homologues. The presence of a TFS2M domain is also indicative of a possible function for the DIDO1 long isoform(Figs 3 and S2). It is the second domain of the elonga-tion factor, TFSII [15], ... addressed, the globalcontext of the domain analyses allows us to draw amore general picture of the involvement of this genein nuclear processes. Nonetheless, the data presentedhere build a hypothesis ... to the Saccharomyces histone-methylating Set1 complex, which contains CGBP andtrithorax homologues [10]. The members of the tritho-rax group encompass various subclasses of gene regu-latory...
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Báo cáo khoa học: Nigrocin-2 peptides from Chinese Odorrana frogs – integration of UPLC/MS/MS with molecular cloning in amphibian skin peptidome analysis pot
... fractionation,MALDI-TOF MS monitoring of separation of the peptides, and automated Edman sequencing of the purified material (i.e. workflow 1, see Experimentalprocedures). This approach was followed for all ... structures of one of the peptides from O. livida (nigrocin-2LVa) and of nigro-cin-2HJ from O. hejiangensis were identical to that of the original nigrocin-2N peptide from the skin of the Oriental ... Molecular Therapeutics Research, School of Pharmacy, Queen’s University, Belfast, Northern Ireland2 Department of Biotechnology, Kluyver Laboratory, Delft University of Technology, Delft, The Netherlands3...
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Báo cáo khoa học: cAMP increases mitochondrial cholesterol transport through the induction of arachidonic acid release inside this organelle in Leydig cells pdf
... steroid synthesis, the release of AAinto the mitochondria is the first stimulator of choles-terol transport. The sustained phase of the acuteresponse will then need the induction of StAR. Wecannot ... mitochondria to a similar extent. To determine if the effect of AA-CoA on cholesteroltransport was due to its conversion to AA by the action of Acot2, we studied the effect of the blockage of ... also that the effect of AA-CoA is due to its con-version to AA into the mitochondria. If this is the case, inhibition of AA-CoA uptake into the mitochon-dria should inhibit steroid synthesis....
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Báo cáo khoa học: A novel retinol-binding protein in the retina of the swallowtail butterfly, Papilio xuthus docx
... finally binds to opsin to form rhodopsin.In addition, they suggested that all-trans-3-hydroxyretinolin the proximal portion of the photoreceptor cell istransported to the distal portion to facilitate ... from the corneal cuticle. This manipulation allows the eyes to beseparated into the distal portion, which contains distal one-third of the photoreceptor layer in addition to the corneaand the ... corresponding to the absorption of the apopro-tein, the absorbance spectrum (Fig. 4A) of the Papilio RBPhas a secondary peak at 330 nm, corresponding to the absorption of 3-hydroxyretinol. The...
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Báo cáo khoa học: "Estimating Upper and Lower Bounds on the Performance of Word-Sense Disambiguation Programs" docx
... advantage of the prior probabilities of the senses, so they would be at a disadvantage relative to the baseline if one of the senses had a very high prior, as is the case for the test word issue. ... Ideally, the baseline system ought to try to estimate the most likely sense for each word in the vocabulary and then assign that sense to each instance of the word in the test set. Unfortunately, ... sample of 97 words; 67 of them were unambiguous and therefore had a baseline performance of 100%) 0 The remaining thirty words are listed along with the number of senses and baseline performance:...
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