PREDICTIVE TOXICOLOGY - CHAPTER 3 pps

... or classification Sec. 3. 3 .3) . 3. 3.1. Feature Selection Due to its high dimensionality, using the complete experi- ment profile to predict the class membership of a novel com- pound is infeasible. ... estimated (36 ). Several web applications that offer an ANOVA-based preprocessing procedure have been pub- lished [e.g., MARAN (34 ), GeneANOVA (37 )]. 3. 2. Microarray Analysis for Mechani...

Ngày tải lên: 11/08/2014, 17:22

... Figure 3. 4. Diafenthiuron may Figure 3. 4 Activation and detoxication of diafenthiuron. O N C N S H H CH CH CH 3 CH 3 CH 3 CH 3 C CH 3 CH 3 CH 3 O N C N CH CH CH 3 CH 3 CH 3 CH 3 C CH 3 CH 3 CH 3 O N C N O H H CH CH CH 3 CH 3 CH 3 CH 3 C CH 3 CH 3 CH 3 O N C N S H H CH CH CH 3 CH 3 CH 3 CH 3 C CH 3 CH 3 CH 3 HO H 2 O 1 O 2 ... diafen...

Ngày tải lên: 11/08/2014, 12:21

... Pickett S, Clementi S. GRid- INdependent Descriptors (GRIND): a novel class of alignment-independent three-dimensional molecular descrip- tors. J Med Chem 2000; 43: 3 233 32 43. 35 . Cramer RD III, Patterson ... Chapter 37 . Glossary of Terms Used in Computa- tional Drug Design (IUPAC Recommendations 1997). Annu Rep Med Chem 1998; 33 :39 7–409. 3D-QSAR: 3D quantitative structure–activity...

Ngày tải lên: 11/08/2014, 17:22

... Substructure-Based SAR in Toxicology 32 9 © 2005 by Taylor & Francis Group, LLC ing human cytochrome P4502D6 (cyp2D6). Other toxicants known to inhibit that isozyme include 1,2 ,3, 6-tetrahydro- 1- methyl-4-phenylpyridine ... of the presence of unrecognized moi- eties. With respect to anthranilate (Fig. 21), unlike the situa- Applications of Substructure-Based SAR in Toxicology 3...

Ngày tải lên: 11/08/2014, 17:22

... t Sci 1994; 34 : 132 6– 133 3. 2. Klopman G, Saiakhov R, Tu M, Pusca F, Rorije E. Computer- assisted evaluation of anaerobic biodegradation products. Pure Appl Chem 1998; 70: 138 5– 139 4. 3. Klopman G, ... 34 : 132 0– 132 5. 8. Klopman G, Wang S. A computer Automated Structure Evaluation (CASE) approach to calculation of partition coefficient. J Comput Chem 1991; 12:1025–1 032 . 9. Klopman...

Ngày tải lên: 11/08/2014, 17:22

... plants Occurrence of Toxicants 33 [16:54 26/8/04 P:/CRC PRESS/ 436 5 MING-HO.751 (1670)/ 436 5-0 03. 3d] Ref: 436 5 MING-HO YU Chap-0 03 Page: 33 3 1-4 4 FIGURE 3. 1 Smog development in Shen-Chen, China: (a) clear ... of Toxicants 39 [16:54 26/8/04 P:/CRC PRESS/ 436 5 MING-HO.751 (1670)/ 436 5-0 03. 3d] Ref: 436 5 MING-HO YU Chap-0 03 Page: 39 3 1-4 4 FIGURE 3. 3 Smog in...

Ngày tải lên: 11/08/2014, 13:22

... not only his pas- sion for the policies but his ability to carry out his plans that made him a successful leader. Chapter 38 ccc_stralser_ch 03_ 3 8-5 6.qxd 7/22/04 9:04 AM Page 38 TLFeBOOK Additionally, ... ex- tensive communication by management with employees. It is the style Leadership and Team Building 43 ccc_stralser_ch 03_ 3 8-5 6.qxd 7/22/04 9:04 AM Page 43 TLFeBOOK Compa...

Ngày tải lên: 01/07/2014, 22:20

... PO 4 -P Onion 2-leaf 0.44 216 (Allium cepa L.) 4-leaf 0 .31 216 6-leaf 0 .34 216 Peas Mid-growth YML 0.25–0 .35 208 (Pisum Early flowering L 0 .33 207 sativum L. ) Flowering Entire Tops 0 .30 –0 .35 208 Entire ... 0.09–0.25 0.29–0 .33 133 arietinum L.) 77 DAP WP 0.15–0.20 Ͼ0.26 133 Dent corn (Zea 30 cm tall WP 0 .30 –0.50 134 mays var. 40–60 cm tall WP 0.22–0.26 135 indentata Tassel Ear L...

Ngày tải lên: 02/07/2014, 00:20

... to-day all preliminaries will be arranged at my father's, and to-morrow, or next day THE COUNT OF MONTE CRISTO ALEXANDRE DUMAS CHAPTER 3 The Catalans. Beyond a bare, weather-worn ... two legs, leaning his elbow on an old worm-eaten table, was a tall young man of twenty, or two-and-twenty, who was looking at her with an air in which vexation and uneasiness were mingled....

Ngày tải lên: 02/07/2014, 05:20

... am." TWENTY YEARS AFTER ALEXANDRE DUMAS CHAPTER 3 3. Dead Animosities. D'Artagnan arrived at the Bastile just as it was striking half-past eight. His visit was announced to the ... D'Artagnan, look up a little! Courage! It is when one is lowest on the wheel of fortune that the merry-go-round wheels and rewards us. This evening your destiny begins to change."...

Ngày tải lên: 03/07/2014, 00:20